By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys.It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. By inhibiting ACE (using ACE inhibitors), angiotensin II production and bradykinin metabolism are reduced, which causes a systematic dilation of the arteries and veins and a reduction in arterial blood pressure.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V72991 | Alamandine | 1176306-10-7 | Alamandine is a vasoactive peptide, a member of the renin-angiotensin system (RAS), and an endogenous ligand of the G protein-coupled receptor MrgD. |
|
V20083 | Lisinopril hydrate (MK-521) | 83915-83-7 | Lisinoprilhydrate (MK-521),an enalapril analog, is a potent angiotensin-converting enzyme (ACE) inhibitorused in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. |
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V25708 | MLN-4760 | 305335-31-3 | MLN-4760 is a novel, potent and selective human angiotensin-converting (ACE2) inhibitor with IC50of 0.44 nM and with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA;IC50, 27 μM). |
|
V16693 | trans-4-Hydroxytamoxifen | 68047-06-3 | 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally bioavailable, selective estrogen receptor modulator (SERM). |
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