| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V3824 | AZD5153 | 1869912-39-9 | AZD-5153 (AZD5153) is a potent, selective, and orally bioavailable BET/BRD4 (bromodomain and extraterminal) bromodomain inhibitor with anticancer activity. |
|
V3743 | BIBX 1382 diHCl | 1216920-18-1 | Falnidamol (formerly known as BIBX 1382) is a potent and selective inhibitor EGFR inhibitor with IC50 of 3 nM and potential anticancer activities; it displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). |
|
V3800 | BMS-711939 | 1000998-62-8 | BMS-711939, an analog of BMS-687453, is a novel potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC50 and IC50 of 4 nM for human PPARα and >1000-fold selectivity vs human PPARγ (EC50 of 4.5 μM) and PPARδ (EC50 > 100 μM) in PPAR-GAL4 transactivation assays. |
|
V3737 | CEP-1347 | 156177-65-0 | CEP-1347 (also known as KT7515), a derivative of the natural product K-252a found in broths of Narcodiopsis bacterium, is a novel, potent and mixed lineage kinase inhibitor (mainly JNK) with IC50 of 30 nM on JNK1. |
|
V2247 | Laduviglusib (CHIR-99021; dihydrochloride) | 2109414-84-6 | Laduviglusib (CHIR-99021; CHIR99021) 2HCl, the dihydrochloride of CHIR-99021, is a potent and selective inhibitor ofglycogen synthase kinase 3α/β (GSK-3α/β) withIC50s of 10 nM and 6.7 nM, respectively. |
|
V3774 | LGD-6972 sodium | 1207989-22-7 | LGD-6972 soidum (LGD6972; MB-11262; MB11262) is a novel and orally bioavailable glucagon receptor antagonist with antidiabetic effects. |
|
V3878 | Migalastat HCl | 75172-81-5 | Migalastat hydrochloride (formerly GR-181413A; AT1001; GR181413A; AT-1001;Galafold), the hydrochloride salt of migalastate, is an inhibitor of α-galactosidase A (α-Gal A) and a medication approved by FDA in August 2018 to treat adults with Fabry disease. |
|
V3646 | Miridesap | 224624-80-0 | Miridesap (formerly known as CPHPC; Ro63-8695; GSK-2315698) is a novel proline-derived small moleculeligand forserum amyloid Pcomponent (SAP). |
|
V3758 | PF-04929113 mesylate | 1173111-67-5 | PF-04929113 mesylate (also known as SNX-5422 mesylate) is a potent and selective inhibitor of heat shock protein 90 (HSP90) with Kd of 41 nM, it induces Her-2 degradation with IC50 of 37 nM. |
|
V3784 | Q-203 Ditosylate | 1566517-83-6 | Q203 is an imidazopyridine amide(IAP)compound that block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. |
|
V3641 | Resibufogenin | 465-39-4 | Resibufogenin (also known as Bufogenin; Recibufogenin; RBG), a component of huachansu,is a natural product withthe potential for the treatment of pancreatic cancer. |
|
V3657 | RG7834 R-isomer (RO7020322) | 2072057-18-0 | RG7834 R-isomer is the R-enantiomer of RG7834 (RO-7020322) which is a novel, potent and orally bioavailable inhibitor of HBV viral gene expression which blocks viral antigen and virion production. |
|
V3823 | S 38093 HCl | 1222097-72-4 | S 38093 is a novel brain-penetrant antagonist (inverse agonist) of the H3 (histamine H3) receptor with Kiof 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively. |
|
V3871 | sarecycline | 1035654-66-0 | Sarecycline (formerlyknown as WC-3035 and P005672; trade name:Seysara)is the first narrow spectrum tetracycline-class antibiotic being developed for acne treatment. |
|
V3842 | SNAP 398299 | 903878-06-8 | SNAP-398299 (also known as SNAP398299), a more water soluble analog ofHT-2157 (SNAP 37889), is a selective, high-affinity, and competitive antagonists ofgalanin-3 receptor(Gal3) that has the potential for the treatment of major depressive disorder. |
|
V3899 | Tamatinib HCl | Tamatinib HCl (formerly known as R406 HCl) is a novel potent and ATP competitive Syk inhibitor with IC50 of 41 nM in cell-free assays, itstrongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. | |
|
V3812 | Taniborbactam (VNRX-5133) | 1613268-23-7 | Taniborbactam (VNRX5133) is a novel, Phase 3-ready, reversible, selective, and injectable ß-lactamase inhibitor (BLI) that features uniquely potent and selective activity against both serine- and metallo-beta-lactamases. |
|
V3768 | Vinflunine (F12158) | 162652-95-1 | Vinflunine(F 12158, BMS 710485) is a new and semi-synthetic analog of the vinca alkaloid vinorelbine that is bi-fluorinated strucuturally. |
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