TSH Receptor

TSH Receptor

As a member of the glycoprotein hormone receptors subfamily of family A G protein-coupled receptors, the TSH receptor (TSHR) functions. Complicated post-translational changes to the TSH receptor (TSHR) include intramolecular cleavage and receptor multimerization. Thyrotropin (TSH) and its endogenous ligand, TSHR, are critical for the development and operation of the thyroid gland, and the TSH/TSHR system must function properly for the thyroid hormones to be produced and released.
Several G-protein subtypes and signaling pathways are activated by the TSHR, with Gs- and Gq-induced signaling likely being the most significant. For the thyroid gland to produce and release thyroid hormones, TSH and its receptor are necessary. Numerous gain- or loss-of-function phenotypes linked to thyroid dysfunction are fundamentally caused by TSHR dysfunctions. There have been suggestions that the TSHR plays a role in the mechanisms and development of ophthalmopathy. Another important autoantigen for autoimmune thyroid gland disorders is TSHR. Furthermore, it has been suggested that TSHR is a powerful target for thyroid cancer, and various experimental drugs are being developed in this regard.

TSH Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V33659 ML-109 (CID-25246343) 1186649-91-1 ML-109 (CID-25246343) is a novel, potent and full thyroid stimulating hormone receptor (TSHR) agonist with an EC50 of 40 nM.
V2924 ML224 1338824-21-7 ML224, also known as NCGC00242364 and ANTAG3, is a selective and inverse agonist of Thyroid Stimulating Hormone Receptor(TSHR).
V74522 TSHR antagonist S37b 2143452-22-4
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