MAP4K

MAP4K

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases.According to studies, MAP4Ks such as MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, MAP4K4/HGK, MAP4K5/KHS, and MAP4K6/MINK cause JNK activation by triggering the MAP3K-MAP2K cascade. The regulation of cell migration, autophagy, apoptosis, and survival is greatly influenced by MAP4Ks. According to a number of studies, MAP4Ks control immune-cell responses through JNK-independent pathways.

When T-cells are activated and inflammatory responses are triggered, MAP4K1/HPK1 and MAP4K4/HGK play harmful roles. In contrast, MAP4K3/GLK contributes to the activation of T cells and autoimmune responses. Additionally, human autoimmune diseases like psoriatic arthritis, rheumatoid arthritis (RA), adult-onset Still's disease, and SLE involve MAP4K1 downregulation and MAP4K3 overexpression in T cells.

MAP4K related products

Structure Cat No. Product Name CAS No. Product Description
V4271 DMX-5804 2306178-56-1 DMX-5804 is a novel, potent, orally bioactive and selectiveMAP4K4(Mitogen-activated protein kinase kinase kinase kinase-4) inhibitor with anIC50of 3 nM, apIC50of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96).
V77906 DS21150768
V74401 GNE-1858 2680616-96-8
V4550 GNE-495 1449277-10-4 GNE-495 is a novel, potent and selectiveMAP4K4(mitogen-activated protein kinase kinase kinase kinase 4) inhibitor with anIC50of 3.7 nM.Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts.
V74424 GNE-6893 2415374-98-8
V74416 HPK1 antagonist-1 2628489-56-3
V74410 HPK1-IN-10 2734168-69-3
V74403 HPK1-IN-11 2734167-68-9
V74412 HPK1-IN-12 2734168-51-3
V74407 HPK1-IN-13 2734168-30-8
V74411 HPK1-IN-14 2734168-45-5
V74406 HPK1-IN-15 2201098-03-3
V74409 HPK1-IN-16 2294965-95-8
V74413 HPK1-IN-17 2403600-07-5
V74408 HPK1-IN-18 2403598-42-3
V74404 HPK1-IN-19 2227609-33-6
V74417 HPK1-IN-20 2561490-78-4
V74420 HPK1-IN-21 2413804-83-6
V74419 HPK1-IN-3 2739844-34-7
V78360 HPK1-IN-31
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