Histamine Receptor

Histamine Receptor

Histamine serves as the endogenous ligand for the class of G protein-coupled receptors known as histamine receptors. The H1 receptor, H2 receptor, H3 receptor, and H4 receptor are the four recognized histamine receptors. A member of the family of G-protein-coupled receptors that resemble Rhodopsin is the histamine receptor H1. This receptor, specifically expressed in smooth muscles, vascular endothelial cells, the heart, and the central nervous system, is triggered by the biogenic amine histamine and is found throughout the body. Gs mediates the positive coupling of H2 receptors to adenylate cyclase. It is a strong inducer of cAMP synthesis, which activates Protein Kinase A. Histamine H3 receptors act as autoreceptors in presynaptic histaminergic neurons and regulate histamine turnover by feedback inhibition of histamine synthesis and release. They are expressed in the central nervous system and to a lesser extent the peripheral nervous system. It has been demonstrated that the mast cell chemotaxis and eosinophil shape change are both mediated by the histamine H4 receptor.

Histamine Receptor related products

Structure Cat No. Product Name CAS No. Product Description
V70329 (R)-Meclizine 189298-48-4
V70364 (Z)-Lafutidine ((Z)-FRG-8813) 206449-93-6
V70328 4'-O-Methylnyasol (Ellisinin A) 79004-25-4
V70347 4-Methylhistamine 36507-31-0
V70315 4-Methylhistamine dihydrochloride 36376-47-3
V70326 4-Methylhistamine hydrochloride 84103-51-5
V70327 A-943931 1027330-97-7
V70332 A-987306 1082954-71-9
V10690 Alcaftadine (R-89674) 147084-10-4 Alcaftadine (R89674; R-89674;trade name Lastacaft) is a potent H1 histamine receptor antagonistused as a topical medication to prevent eye irritation caused by allergic conjunctivitis.
V8045 Betahistine 5638-76-6 Betahistine (also known as PT-9) is a potent histamine H3 receptor inhibitor with IC50 of 1.9 μM.
V70346 Betahistine-d3 dihydrochloride (Betahistine-d3 dihydrochloride) 244094-72-2
V70312 Betazole (Ametazole) 105-20-4
V70345 Betazole dihydrochloride (Ametazole dihydrochloride) 138-92-1
V70339 Bilastine-d6 (Bilastine d6) 1215358-58-9
V70349 Bufrolin 54867-56-0
V70369 Carcinine (β-Alanylhistamine) 56897-53-1
V70350 Carebastine-d5 (Carebastine d5) 1189661-02-6
V70351 Carebastine-d5 Methyl Ester 1190019-51-2
V70317 Cetirizine Impurity C 83881-59-8
V70357 Cetirizine Impurity D 346451-15-8
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