GLUTs (glucose transporters) are proteins with 12 membrane-spanning regions. GLUTs use a facilitated diffusion mechanism to move glucose across the plasma membrane.
The uniporter protein GLUT1 (SLC2A1) aids in the movement of glucose across the plasma membranes of mammalian cells. A transmembrane carrier protein called GLUT2 (SLC2A2) facilitates the movement of glucose across cell membranes. With a focus on the brain, GLUT3 (SLC2A3) has a strong affinity for glucose. The transport of glucose across the plasma membranes of mammalian cells is facilitated by GLUT3. The heart, skeletal muscle, adipose tissue, and brain all contain GLUT4 (SLC2A4). An insulin-responsive glucose transporter is GLUT4.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V93098 | (Rac)-Glutipyran | 350993-69-0 | (Rac)-Glutipyran is a broad-spectrum GLUT inhibitor targeting GLUT1 and GLUT3. |
|
V118933 | 3-Deoxy-3-fluoro-D-fructose | 110925-86-5 | 3-Deoxy-3-fluoro-D-fructose (compound 12) is a derivative of 2,5-dehydro-D-mannitol and is a selective hexose transporter 5 (GLUT5) probe. |
|
V79866 | A-446 | A-446 is a potent glutaminase inhibitor (antagonist) with IC50 of 31 nM. | |
|
V78070 | Antitumor agent-102 | Antitumor agent-102 (compound 10) is a conjugate of the topoisomerase I inhibitor SN38 and a glucose transporter inhibitor, targeting colorectal cancer. | |
|
V2770 | BAY-876 | 1799753-84-6 | BAY-876 (BAY876) isa potent and highly-selective GLUT1 (SLC2A1) inhibitor with potential anticancer activity. |
|
V74193 | DRB18 | 2863686-81-9 | DRB18 is a potent pan-inhibitor of glucose transporters (GLUT). |
|
V79884 | GLS1 Inhibitor-7 | GLS1 Inhibitor-7 (compound 4d) is a GLS1 inhibitor (IC50=46.7 μM) with potential anti-cancer, anti-aging, and anti-obesity properties. | |
|
V79612 | GLUT1-IN-1 | GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor (antagonist) with GLUT1-specific inactivation ability. | |
|
V74200 | GLUT1-IN-2 | 305357-89-5 | GLUT1-IN-2 (compound 17) is a GLUT1 inhibitor (antagonist) with IC50 of 12 μM. |
|
V87158 | Glutor | 2561471-22-3 | Glutor is a selective GLUT 1/2/3 inhibitor that inhibits glucose uptake. |
|
V111552 | GTP-γ-S | 37589-80-3 | GTPγS (guanosine 5'-[γ-thio]triphosphate) is a G protein activator that protects proteins from degradation by proteolytic enzymes. |
|
V80641 | LWG-301 | LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) (IC50=7 nM). | |
|
V76752 | MOTS-c(human) acetate | MOTS-c(human) acetate is a mitochondria-derived peptide that induces the accumulation of the AMP analog AICAR and increases the activation of AMPK and the expression of its downstream GLUT4. | |
|
V74197 | MSNBA | 852702-51-3 | MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. |
|
V85106 | Physagulide Y | ||
|
V74199 | SLC26A3-IN-1 | 307552-53-0 | SLC26A3-IN-1 is an inhibitor (blocker/antagonist) of the anion exchange protein SLC26A3 (IC50=340 nM). |
|
V74196 | SLC26A3-IN-2 | 950348-60-4 | SLC26A3-IN-2 is an orally bioavailable inhibitor of the anion exchange protein SLC26A3 (IC50=360 nM). |
|
V74195 | SLC26A3-IN-3 | 2369983-43-5 | SLC26A3-IN-3 (compound 4az) is an inhibitor (blocker/antagonist) of SLC26A3 (IC50= 40 nM). |
|
V110468 | SLC2A1 modulator-1 | 393845-92-6 | SLC2A1 Modulator-1 is a modulator for SLC2A1. |
|
V51461 | SW-157765 | 332063-87-3 | SW157765 is a selective non-canonical transporter GLUT8 (SLC2A8) selective. |
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