A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V40665 | 1V209 | 1062444-54-5 | 1V209 is a novel and potent Toll-like receptor 7 (TLR7) agonistwithanti-tumor activity. |
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V74350 | 6'-Sialyllactose | 35890-39-2 | 6'-Sialyllactose is a sialylated human milk oligosaccharide that promotes the proliferation of bifidobacteria and shapes the intestinal microbiota. |
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V74342 | ABR-238901 | 1638200-22-2 | ABR-238901 is an orally bioactive S100A8/A9 blocker that can inhibit the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). |
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V74343 | Afimetoran (BMS-986256) | 2171019-55-7 | Afimetoran is a toll-like receptor blocker (antagonist) that may be utilized in the research/study of inflammatory and autoimmune diseases. |
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V74373 | Agatolimod sodium (ODN 7909; PF-3512676; CpG 7909) | 541547-35-7 | Agatolimod sodium (ODN 7909) is a class B CpG ODN and a< B >TLR9 agonist. |
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V51784 | AXC-715 hydrochloride | 2490497-93-1 | AXC-715 (T785) HCl is a TLR7/TLR8 dual agonist obtained from patent WO2020168017 A1. |
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V78438 | Biotin-labeled Agatolimod sodium | Biotin-labeled Agatolimod (sodium) is a class B CpG ODN and a TLR9 agonist. | |
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V78439 | Biotin-labeled ODN 1018 sodium | Biotin-labeled ODN 1018 (sodium) is a TLR9 agonist. | |
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V78440 | Biotin-labeled ODN 1585 sodium | Biotin-labeled ODN 1585 (sodium) is a potent inducer of IFN and TNFα production. | |
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V78441 | Biotin-labeled ODN 1668 sodium | Biotin-labeled ODN 1668 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
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V78442 | Biotin-labeled ODN 1826 sodium | Biotin-labeled ODN 1826 (sodium) is a class B CpG ODN and a TLR9 agonist. | |
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V78443 | Biotin-labeled ODN 2088 sodium | Biotin-labeled ODN 2088 (sodium) is a TLR3, TLR7 and TLR9 inhibitor. | |
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V78444 | Biotin-labeled ODN 2216 sodium | Biotin-labeled ODN 2216 (sodium) is a TLR9 agonist. | |
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V78445 | Biotin-labeled ODN 2395 sodium | Biotin-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist. | |
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V78446 | Biotin-labeled ODN TTAGGG sodium | Biotin-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS. | |
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V74356 | Cavrotolimod (AST-008) | 2378664-12-9 | Cavrotolimod is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response. |
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V78661 | Cavrotolimod sodium (AST-008 sodium) | Cavrotolimodsodium is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response. | |
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V74376 | CAY10614 | 1202208-36-3 | CAY10614 is a potent TLR4 antagonist. |
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V74360 | Chitohexaose hexahydrochloride | 127171-88-4 | Chitohexaose hexa HCl is a chitosan oligosaccharide with anti-inflammatory activities. |
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V51783 | CL-097 | 1026249-18-2 | CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages. |
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