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TLR

TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Structure Cat No. Product Name CAS No. Product Description
1V209 V40665 1V209 1062444-54-5 1V209 is a novel and potent Toll-like receptor 7 (TLR7) agonistwithanti-tumor activity.
6'-Sialyllactose V74350 6'-Sialyllactose 35890-39-2 6'-Sialyllactose is a sialylated human milk oligosaccharide that promotes the proliferation of bifidobacteria and shapes the intestinal microbiota.
ABR-238901 V74342 ABR-238901 1638200-22-2 ABR-238901 is an orally bioactive S100A8/A9 blocker that can inhibit the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4 (toll-like receptor 4).
Afimetoran (BMS-986256) V74343 Afimetoran (BMS-986256) 2171019-55-7 Afimetoran is a toll-like receptor blocker (antagonist) that may be utilized in the research/study of inflammatory and autoimmune diseases.
Agatolimod sodium (ODN 7909; PF-3512676; CpG 7909) V74373 Agatolimod sodium (ODN 7909; PF-3512676; CpG 7909) 541547-35-7 Agatolimod sodium (ODN 7909) is a class B CpG ODN and a< B >TLR9 agonist.
AXC-715 hydrochloride V51784 AXC-715 hydrochloride 2490497-93-1 AXC-715 (T785) HCl is a TLR7/TLR8 dual agonist obtained from patent WO2020168017 A1.
BI1543673 V97097 BI1543673 BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor.
Biotin-labeled Agatolimod sodium V78438 Biotin-labeled Agatolimod sodium Biotin-labeled Agatolimod (sodium) is a class B CpG ODN and a TLR9 agonist.
Biotin-labeled ODN 1018 sodium V78439 Biotin-labeled ODN 1018 sodium Biotin-labeled ODN 1018 (sodium) is a TLR9 agonist.
Biotin-labeled ODN 1585 sodium V78440 Biotin-labeled ODN 1585 sodium Biotin-labeled ODN 1585 (sodium) is a potent inducer of IFN and TNFα production.
Biotin-labeled ODN 1668 sodium V78441 Biotin-labeled ODN 1668 sodium Biotin-labeled ODN 1668 (sodium) is a class B CpG ODN and a TLR9 agonist.
Biotin-labeled ODN 1826 sodium V78442 Biotin-labeled ODN 1826 sodium Biotin-labeled ODN 1826 (sodium) is a class B CpG ODN and a TLR9 agonist.
Biotin-labeled ODN 2088 sodium V78443 Biotin-labeled ODN 2088 sodium Biotin-labeled ODN 2088 (sodium) is a TLR3, TLR7 and TLR9 inhibitor.
Biotin-labeled ODN 2216 sodium V78444 Biotin-labeled ODN 2216 sodium Biotin-labeled ODN 2216 (sodium) is a TLR9 agonist.
Biotin-labeled ODN 2395 sodium V78445 Biotin-labeled ODN 2395 sodium Biotin-labeled ODN 2395 (sodium) is a class C CpG ODN and a TLR9 agonist.
Biotin-labeled ODN TTAGGG sodium V78446 Biotin-labeled ODN TTAGGG sodium Biotin-labeled ODN TTAGGG (sodium) is an inhibitor oligonucleotide that is an antagonist of TLR9, AIM2 and cGAS.
BNT411 V87025 BNT411 2296821-50-4 BNT411 is a selective TLR7 agonist that can induce IFNa release in vitro and in vivo.
Cavrotolimod (AST-008) V74356 Cavrotolimod (AST-008) 2378664-12-9 Cavrotolimod is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response.
Cavrotolimod sodium (AST-008 sodium) V78661 Cavrotolimod sodium (AST-008 sodium) Cavrotolimodsodium is a spherical nucleic acid (SNA) modified with B-type CpG oligonucleotides that stimulates TLR9 and elicits an immune response.
CAY10614 V74376 CAY10614 1202208-36-3 CAY10614 is a potent TLR4 antagonist.
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