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P2Y Receptor

P2Y Receptor

G protein-coupled receptors (GPCRs) known as P2Y receptors are activated by the extracellular nucleotides ATP, UTP, and UDP. Mammalian P2Y receptors come in eight different subtypes: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14. The P2Y receptors play significant roles in physiology and pathophysiology, including inflammatory reactions and neuropathic pain, and are expressed in a variety of cell types.
The P2Y family can be further divided into two subfamilies: P2Y12, P2Y13, and P2Y14Rs ("P2Y12-like"), which inhibit adenylate cyclase through Gi protein, and P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs ("P2Y1-like"), which stimulate phospholipase C (PLC) through Gq protein. Other effector pathways have also been identified, such as the coupling of the P2Y11R to Gs and Gq in some cells to stimulate the production of cyclic AMP.

P2Y Receptor related products

Structure Cat No. Product Name CAS No. Product Description
普拉格雷盐酸盐 V6224 Prasugrel Hydrochloride (PCR 4099; CS-747) 389574-19-0 Prasugrel Hydrochloride (formerly also known as CS-747,PCR 4099 and LY640315),a piperazine derivative,is a novel and potentthienopyridine ADP receptor (P2Y12) antagonist used for the reduction of thrombotic cardiovascular events.
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