The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70457 | (2R,3S)-Chlorpheg | 140924-23-8 | (2R,3S)-Chlorpheg is a weak antagonist of L-homocysteine (L-HCA)-induced depolarization. |
|
V102520 | (R)-3,4-DCPG | 201730-10-1 | (R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. |
|
V70461 | (R)-3C4HPG | 13861-03-5 | (R)-3C4HPG is an NMDA receptor blocker (antagonist). |
|
V94535 | (R)-AMPA | 83654-13-1 | (R)-AMPA is an inactive AMPA receptor ligand that inhibits the release of excitatory amino acids from neurons. |
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V70475 | (R)-Lanicemine ((R)-Lanicemine; (R)-AZD6765) | 190581-71-6 | (R)-Lanicemine ((R)-AZD6765) is the less active R-isomer of Lanicemine. |
|
V106667 | (R,R)-Traxoprodil | 134234-13-2 | (R,R)-Trexolodil is the (R,R)-enantiomer of trasorodil. |
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V70433 | (R,S)-3,4-Dicarboxyphenylglycine ((R,S)-3,4-DCPG) | 176796-64-8 | (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. |
|
V70395 | (Rac)-Lanicemine ((Rac)-Lanicemine; (Rac)-AZD6765) | 61890-25-3 | (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. |
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V70413 | (Rac)-NMDAR antagonist 1 | 2435557-99-4 | (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. |
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V70485 | (RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) | 171259-81-7 | (RS)-AMPA ((±)-AMPA) HBr is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid. |
|
V96916 | (RS)-AMPA hydrochloride | 2922283-04-1 | (RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and a potent and selective agonist of the excitatory neurotransmitter L-glutamate. |
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V70392 | (RS)-AMPA monohydrate ((±)-AMPA monohydrate) | 76463-67-7 | (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid. |
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V70481 | (RS)-CPP ((±)-CPP) | 100828-16-8 | (RS)-CPP ((±)-CPP) is a potent and specific NMDA antagonist. |
|
V70428 | (S)-(-)-HA 966 ((-)-HA 966) | 111821-58-0 | (S)-(-)-HA 966 ((-)-HA 966) is a bioactive molecule similar to γ-hydroxybutyrate and a weakly active NMDA receptor antagonist. |
|
V70411 | (S)-AMPA (L-AMPA) | 83643-88-3 | (S)-AMPA (L-AMPA) is the active S-enantiomer of AMPA and is a potent and specific AMPA receptor agonist (activator). |
|
V70419 | 1-Aminocyclobutanecarboxylic acid | 22264-50-2 | 1-Aminocyclobutanecarboxylic acid is a partial NMDA receptor agonist (activator) acting on the NR1 glycine site. |
|
V30846 | 1-BCP | 34023-62-6 | 1-BCP (Piperonylic acid piperidide) is a centrally active molecule that regulates the gated current of AMPA receptors. |
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V104978 | 17alpha-Hydroxywithanolide D | 17alpha-Hydroxywithanolide D is an allosteric modulator of NMDA receptor with IC50 of 44.24 nM. | |
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V3755 | NBQX | 118876-58-7 | NBQX (also known asFG9202) is a novel and potentantagonist ofaminomethylphosphonic acid receptor (AMPAR)with IC50of 0.7 ± 0.1 μM. |
|
V103210 | 3-Methoxy PCE hydrochloride | 1797121-52-8 | 3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine, an NMDA receptor antagonist with a pKi of 7.22. |
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