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iGluR

iGluR

The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and  receptors, share a similar amino acid sequence.

The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
 

iGluR related products

Structure Cat No. Product Name CAS No. Product Description
(2R,3S)-Chlorpheg V70457 (2R,3S)-Chlorpheg 140924-23-8 (2R,3S)-Chlorpheg is a weak antagonist of L-homocysteine (L-HCA)-induced depolarization.
(R)-3,4-DCPG V102520 (R)-3,4-DCPG 201730-10-1 (R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA.
(R)-3C4HPG V70461 (R)-3C4HPG 13861-03-5 (R)-3C4HPG is an NMDA receptor blocker (antagonist).
(R)-AMPA V94535 (R)-AMPA 83654-13-1 (R)-AMPA is an inactive AMPA receptor ligand that inhibits the release of excitatory amino acids from neurons.
(R)-Lanicemine ((R)-Lanicemine; (R)-AZD6765) V70475 (R)-Lanicemine ((R)-Lanicemine; (R)-AZD6765) 190581-71-6 (R)-Lanicemine ((R)-AZD6765) is the less active R-isomer of Lanicemine.
(R,R)-Traxoprodil V106667 (R,R)-Traxoprodil 134234-13-2 (R,R)-Trexolodil is the (R,R)-enantiomer of trasorodil.
(R,S)-3,4-Dicarboxyphenylglycine ((R,S)-3,4-DCPG) V70433 (R,S)-3,4-Dicarboxyphenylglycine ((R,S)-3,4-DCPG) 176796-64-8 (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist.
(Rac)-Lanicemine ((Rac)-Lanicemine; (Rac)-AZD6765) V70395 (Rac)-Lanicemine ((Rac)-Lanicemine; (Rac)-AZD6765) 61890-25-3 (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine.
(Rac)-NMDAR antagonist 1 V70413 (Rac)-NMDAR antagonist 1 2435557-99-4 (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1.
(RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) V70485 (RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) 171259-81-7 (RS)-AMPA ((±)-AMPA) HBr is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid.
(RS)-AMPA hydrochloride V96916 (RS)-AMPA hydrochloride 2922283-04-1 (RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and a potent and selective agonist of the excitatory neurotransmitter L-glutamate.
(RS)-AMPA monohydrate ((±)-AMPA monohydrate) V70392 (RS)-AMPA monohydrate ((±)-AMPA monohydrate) 76463-67-7 (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid.
(RS)-CPP ((±)-CPP) V70481 (RS)-CPP ((±)-CPP) 100828-16-8 (RS)-CPP ((±)-CPP) is a potent and specific NMDA antagonist.
(S)-(-)-HA 966 ((-)-HA 966) V70428 (S)-(-)-HA 966 ((-)-HA 966) 111821-58-0 (S)-(-)-HA 966 ((-)-HA 966) is a bioactive molecule similar to γ-hydroxybutyrate and a weakly active NMDA receptor antagonist.
(S)-AMPA (L-AMPA) V70411 (S)-AMPA (L-AMPA) 83643-88-3 (S)-AMPA (L-AMPA) is the active S-enantiomer of AMPA and is a potent and specific AMPA receptor agonist (activator).
1-Aminocyclobutanecarboxylic acid V70419 1-Aminocyclobutanecarboxylic acid 22264-50-2 1-Aminocyclobutanecarboxylic acid is a partial NMDA receptor agonist (activator) acting on the NR1 glycine site.
1-BCP V30846 1-BCP 34023-62-6 1-BCP (Piperonylic acid piperidide) is a centrally active molecule that regulates the gated current of AMPA receptors.
17alpha-Hydroxywithanolide D V104978 17alpha-Hydroxywithanolide D 17alpha-Hydroxywithanolide D is an allosteric modulator of NMDA receptor with IC50 of 44.24 nM.
2,3-二氧代-6-硝基-7-硫酰胺基苯并(f)喹喔啉 V3755 NBQX 118876-58-7 NBQX (also known asFG9202) is a novel and potentantagonist ofaminomethylphosphonic acid receptor (AMPAR)with IC50of 0.7 ± 0.1 μM.
3-Methoxy PCE hydrochloride V103210 3-Methoxy PCE hydrochloride 1797121-52-8 3-Methoxy PCE (3-MEO PCE) hydrochloride is an arylcyclohexylamine, an NMDA receptor antagonist with a pKi of 7.22.
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