The neurotransmitter glutamate activates the iGluR (ionotropic glutamate receptor), an ion channel that is ligand-gated. The central ion channel pore is formed by four large subunits of the integral membrane protein iGluR. All known glutamate receptor subunits, including the AMPA, kainate, NMDA, and receptors, share a similar amino acid sequence.
The primary charge carriers during basal transmission are AMPA receptors, which allow an influx of sodium ions to depolarize the postsynaptic membrane. Magnesium ions block NMDA receptors, which only allow ion flux after a previous depolarization. They can now serve as coincidence detectors for synaptic plasticity because of this. NMDA receptors allow calcium to enter the body, which permanently changes how strongly synaptic transmission is carried out.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70457 | (2R,3S)-Chlorpheg | 140924-23-8 | (2R,3S)-Chlorpheg is a weak antagonist of L-homocysteine (L-HCA)-induced depolarization. |
|
V70461 | (R)-3C4HPG | 13861-03-5 | (R)-3C4HPG is an NMDA receptor blocker (antagonist). |
|
V70475 | (R)-Lanicemine ((R)-Lanicemine; (R)-AZD6765) | 190581-71-6 | (R)-Lanicemine ((R)-AZD6765) is the less active R-isomer of Lanicemine. |
|
V70433 | (R,S)-3,4-Dicarboxyphenylglycine ((R,S)-3,4-DCPG) | 176796-64-8 | (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. |
|
V70395 | (Rac)-Lanicemine ((Rac)-Lanicemine; (Rac)-AZD6765) | 61890-25-3 | (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. |
|
V70413 | (Rac)-NMDAR antagonist 1 | 2435557-99-4 | (Rac)-NMDAR antagonist 1 is the racemate of NMDAR antagonist 1. |
|
V70485 | (RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) | 171259-81-7 | (RS)-AMPA ((±)-AMPA) HBr is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid. |
|
V70392 | (RS)-AMPA monohydrate ((±)-AMPA monohydrate) | 76463-67-7 | (RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and specific agonist of the excitatory neurotransmitter L-glutamic acid. |
|
V70481 | (RS)-CPP ((±)-CPP) | 100828-16-8 | (RS)-CPP ((±)-CPP) is a potent and specific NMDA antagonist. |
|
V70428 | (S)-(-)-HA 966 ((-)-HA 966) | 111821-58-0 | (S)-(-)-HA 966 ((-)-HA 966) is a bioactive molecule similar to γ-hydroxybutyrate and a weakly active NMDA receptor antagonist. |
|
V70411 | (S)-AMPA (L-AMPA) | 83643-88-3 | (S)-AMPA (L-AMPA) is the active S-enantiomer of AMPA and is a potent and specific AMPA receptor agonist (activator). |
|
V70419 | 1-Aminocyclobutanecarboxylic acid | 22264-50-2 | 1-Aminocyclobutanecarboxylic acid is a partial NMDA receptor agonist (activator) acting on the NR1 glycine site. |
|
V30846 | 1-BCP | 34023-62-6 | 1-BCP (Piperonylic acid piperidide) is a centrally active molecule that regulates the gated current of AMPA receptors. |
|
V69121 | 4′-Demethylnobiletin | 34810-62-3 | 4′-Demethylnobiletin is a biobioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling. |
|
V85176 | 5,7-Dichlorokynurenic acid sodium (5,7-DCKA sodium) | 1184986-70-6 | |
|
V85165 | 5-Iodowillardiine | 140187-25-3 | |
|
V70389 | 6-Hydroxykynurenic acid (6-HKA) | 3778-29-8 | 6-Hydroxykynurenic acid (6-HKA) is an analogue of kynurenic acid (KYNA) and can be extracted from Ginkgo leaves. |
|
V84793 | AChE-IN-53 | 2807436-94-6 | |
|
V69998 | Alaproclate hydrochloride (GEA 654 hydrochloride; A03 hydrochloride) | 60719-83-7 | Alaproclate (GEA 654) HCl is a selective, orally bioactive serotonin reuptake inhibitor (SSRI). |
|
V70425 | AMPA receptor modulator-2 | 2034181-36-5 | AMPA receptor modulator-2 (Example 134) is a modulator of AMPA receptors, with pIC50 of 10.1 for TARPγ2-dependent AMPA receptors. |
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