Ribosomal S6 Kinase (RSK) is a family of serine/threonine protein kinases involved in the regulation of cell viability.In response to mitogens, RSK is phosphorylated by the activation of one or more protein kinase cascades. The 70 kDa and 90 kDa S6 kinase families, which can be distinguished by size, are the two distinct mitogen-activated S6 kinase families that phosphorylate S6 in vivo. The activation of both S6 kinases occurs through serine/threonine phosphorylation.
The Ras/Raf/MEK/ERK signaling pathway's downstream effectors are members of the highly conserved Ser/Thr kinase family known as p90 ribosomal s6 kinase (1-4). They control a variety of cellular functions, including cell growth, motility, survival, and proliferation. AGC family member and key player in the mTOR signaling cascade is the p70 ribosomal protein S6 kinase.It is a multifunctional Ser/Thr kinase. Numerous cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth, and apoptosis are closely correlated with the p70 ribosomal protein S6 kinase.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69552 | AD57 hydrochloride | 2320261-72-9 | AD57 is an orally bioactive multikinase inhibitor that can suppress RET, BRAF, S6K, and Src activities. |
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V6571 | BIX 02565 | 1311367-27-7 | BIX 02565 is a novel RSK2 inhibitor with IC50 of 1 nM. |
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V29201 | CMK | 821794-90-5 | CMK is an RSK2 kinase inhibitor (antagonist) with similar potency but lower chemical stability than FMK. |
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V70259 | Coronarin A | 119188-33-9 | Coronarin A is an orally bioactive naturally occurring compound that can inhibit mTORC1 and S6K1 and increases IRS1 activity. |
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V24250 | LJH685 | 1627710-50-2 | LJH685 is a potent, selective, ATP-competitive RSK inhibitor that can suppress RSK1/2/3 bioactivity with IC50 of 6, 5, and 4 nM. |
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V2667 | Pluripotin (SC1) | 839707-37-8 | Pluripotin (also known as SC1; SC-1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP as well as asustainer of mES self-renewal. |
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V74151 | RSK4-IN-1 | 2755819-10-2 | RSK4-IN-1 has potent RSK4 inhibitory activity with IC50 of 9.5 nM. |
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V81345 | S6 Kinase Substrate Peptide 32 | S6 Kinase Substrate Peptide 32 is a substrate for Ribosomal S6 Kinase (RSK) and may be utilized to measure the kinase activity of RSKs that phosphorylates ribosomal protein S6. | |
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V4446 | SL0101 | 77307-50-7 | SL0101 (SL 0101-1) a kaempferol glycoside isolated from the tropical plant F. refracta, is a novel, potent, cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. |
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V74150 | TAS0612 | 2148902-58-1 | TAS0612 is a novel oral RSK, AKT and S6K inhibitor. |
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