The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.
While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75831 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B | 154022-51-2 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester analogue of Tenacienin B, which can be extracted from Garcinia cambogia (MTC). |
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V2332 | AKI603 | 1432515-73-5 | AKI603 is an AurorKinase A (AurA) inhibitor (antagonist) with IC50 of 12.3 nM that was developed to overcome the BCR-ABL-T315I resistance mutation in leukemia. |
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V78293 | Aurora A inhibitor 3 | Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with IC50 of 0.78 μM. | |
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V2345 | Aurora Kinase Inhibitor II | 331770-21-9 | AurorKinase inhibitor-2 is a selective and ATP-competitive AurorKinase inhibitor (antagonist) with IC50s of 310 nM and 240 nM for Aurora A and Aurora B respectively. |
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V4055 | Aurora Kinase Inhibitor III | 879127-16-9 | Aurora kinase inhibitor III, a 2,4-dianilinopyrimidine compound, is a novel, potent, highly selective, cell-permeable and ATP-competitive inhibitor of aurora related kinase (ARK) with IC50 of 42 nM for Aurora A kinase. |
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V75830 | Aurora kinase inhibitor-11 | 923946-98-9 | Aurora kinase inhibitor-11 (compound 25) is an inhibitor (blocker/antagonist) of Aurora Kinase with IC50 of 0.14 μM. |
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V78294 | Aurora kinase inhibitor-12 | AurorKinase Inhibitor-12 (Compound 1a) is an inhibitor (blocker/antagonist) of aurorKinase, a key enzyme involved in tumor growth. | |
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V52376 | Aurora Kinases-IN-3 | 2840558-83-8 | Aurora Kinases-IN-3 (Compound 15a) is an orally bioactive AURKB inhibitor that induces AURKB inhibitory activity by disrupting the mitotic localization of AURKB rather than inhibiting its phosphorylation of H3 at Ser10. |
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V55049 | Aurora Kinases-IN-4 | 2877011-84-0 | Aurora Kinases-IN-4 (Compound 11c) is a covalent ATP-competitive aurora kinase A inhibitor (IC50= 1.7 nM). |
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V4257 | Barasertib (AZD1152) | 722543-31-9 | Barasertib phosphate (also known as AZD-1152), the phosphate salt of Barasertib, is an investigational, highly selective, orally bioavailable small-molecule Aurora B inhibitor (IC50 = 0.37 nM in a cell-free assay) with anticancer activity. |
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V52289 | CD532 | 1639009-81-6 | CD532 is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM. |
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V53099 | CD532 hydrochloride | 2926498-81-7 | CD532 HCl is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM. |
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V4411 | Ilorasertib | 1227939-82-3 | Ilorasertib (also known as ABT-348) is a potent, novel, orally bioavailable and ATP-competitive multi-kinase inhibitor withIC50s for inhibiting binding Aurora B (7 nM), C (1 nM), and A (120 nM), and also inhibits RET tyrosine kinase, PDGFRβ, and Flt1 withIC50s of 7 nM, 3 nM and 32 nM. |
|
V51923 | JB170 | 2705844-82-0 | JB170 is a potent and specific PROTAC-mediated degrader of AURORA-A (DC50=28 nM) formed by linking Alisertib to the Cereblon ligand Thalidomide. |
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V4347 | Phthalazinone pyrazole | 880487-62-7 | Phthalazinone pyrazole is a potent, selective, orally bioactive Aurora-Kinase inhibitor (antagonist) with IC50 of 0.031 μM. |
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V4666 | SCH-1473759 | 1094069-99-4 | SCH-1473759 (SCH1473759) is a novel, potent and selective aurora inhibitor with anticancer effects. |
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V35264 | SP-96 | 2682114-54-9 | SP-96 is a specific and ATP-competitive Aurora B inhibitor (antagonist) with IC50 of 0.316 nM and >2000-fold selectivity for FLT3 and KIT. |
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V55050 | Tenacienin B | 80508-42-5 | Tenacigenin B is a steroid extracted from Alocasia. |
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V55051 | Tinengotinib (TT 00420) | 2230490-29-4 | Tinengotinib is a modulator of one or more protein kinases, such as Aurora kinase and VEGFR kinase. |
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V35166 | Tripolin A ((E)-Tripolin A) | 1148118-92-6 | Tripolin A ((E)-Tripolin A) is a specific, non-ATP competitive Aurora A kinase inhibitor (antagonist) with IC50s of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively. |
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