Aurora Kinase

Aurora Kinase

The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.

While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.

Aurora Kinase related products

Structure Cat No. Product Name CAS No. Product Description
V75831 11α-O-Tigloyl-12β-O-acetyltenacigenin B 154022-51-2 11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester analogue of Tenacienin B, which can be extracted from Garcinia cambogia (MTC).
V2332 AKI603 1432515-73-5 AKI603 is an AurorKinase A (AurA) inhibitor (antagonist) with IC50 of 12.3 nM that was developed to overcome the BCR-ABL-T315I resistance mutation in leukemia.
V78293 Aurora A inhibitor 3 Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with IC50 of 0.78 μM.
V2345 Aurora Kinase Inhibitor II 331770-21-9 AurorKinase inhibitor-2 is a selective and ATP-competitive AurorKinase inhibitor (antagonist) with IC50s of 310 nM and 240 nM for Aurora A and Aurora B respectively.
V4055 Aurora Kinase Inhibitor III 879127-16-9 Aurora kinase inhibitor III, a 2,4-dianilinopyrimidine compound, is a novel, potent, highly selective, cell-permeable and ATP-competitive inhibitor of aurora related kinase (ARK) with IC50 of 42 nM for Aurora A kinase.
V75830 Aurora kinase inhibitor-11 923946-98-9 Aurora kinase inhibitor-11 (compound 25) is an inhibitor (blocker/antagonist) of Aurora Kinase with IC50 of 0.14 μM.
V78294 Aurora kinase inhibitor-12 AurorKinase Inhibitor-12 (Compound 1a) is an inhibitor (blocker/antagonist) of aurorKinase, a key enzyme involved in tumor growth.
V52376 Aurora Kinases-IN-3 2840558-83-8 Aurora Kinases-IN-3 (Compound 15a) is an orally bioactive AURKB inhibitor that induces AURKB inhibitory activity by disrupting the mitotic localization of AURKB rather than inhibiting its phosphorylation of H3 at Ser10.
V55049 Aurora Kinases-IN-4 2877011-84-0 Aurora Kinases-IN-4 (Compound 11c) is a covalent ATP-competitive aurora kinase A inhibitor (IC50= 1.7 nM).
V4257 Barasertib (AZD1152) 722543-31-9 Barasertib phosphate (also known as AZD-1152), the phosphate salt of Barasertib, is an investigational, highly selective, orally bioavailable small-molecule Aurora B inhibitor (IC50 = 0.37 nM in a cell-free assay) with anticancer activity.
V52289 CD532 1639009-81-6 CD532 is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM.
V53099 CD532 hydrochloride 2926498-81-7 CD532 HCl is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM.
V84552 FAK/aurora kinase-IN-1 2178117-69-4
V4411 Ilorasertib 1227939-82-3 Ilorasertib (also known as ABT-348) is a potent, novel, orally bioavailable and ATP-competitive multi-kinase inhibitor withIC50s for inhibiting binding Aurora B (7 nM), C (1 nM), and A (120 nM), and also inhibits RET tyrosine kinase, PDGFRβ, and Flt1 withIC50s of 7 nM, 3 nM and 32 nM.
V51923 JB170 2705844-82-0 JB170 is a potent and specific PROTAC-mediated degrader of AURORA-A (DC50=28 nM) formed by linking Alisertib to the Cereblon ligand Thalidomide.
V4347 Phthalazinone pyrazole 880487-62-7 Phthalazinone pyrazole is a potent, selective, orally bioactive Aurora-Kinase inhibitor (antagonist) with IC50 of 0.031 μM.
V4666 SCH-1473759 1094069-99-4 SCH-1473759 (SCH1473759) is a novel, potent and selective aurora inhibitor with anticancer effects.
V35264 SP-96 2682114-54-9 SP-96 is a specific and ATP-competitive Aurora B inhibitor (antagonist) with IC50 of 0.316 nM and >2000-fold selectivity for FLT3 and KIT.
V55050 Tenacienin B 80508-42-5 Tenacigenin B is a steroid extracted from Alocasia.
V55051 Tinengotinib (TT 00420) 2230490-29-4 Tinengotinib is a modulator of one or more protein kinases, such as Aurora kinase and VEGFR kinase.
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