The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.
While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V75831 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B | 154022-51-2 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester analogue of Tenacienin B, which can be extracted from Garcinia cambogia (MTC). |
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V97440 | AJI-100 | 844435-10-5 | AJI-100 is a dual-target inhibitor of Aurora Kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. |
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V97418 | AJI-214 | 1395886-20-0 | AJI-214 is a dual-target inhibitor of Aurora Kinase A and JAK2. It inhibits T cell mitosis and cell polarity by directly blocking Aurora Kinase A, and inhibits STAT3 phosphorylation by inhibiting JAK2 activation, thereby reducing TH1 and TH17 cell differentiation. It can be used to regulate immune responses and prevent graft-versus-host disease (GVHD). |
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V2332 | AKI603 | 1432515-73-5 | AKI603 is an AurorKinase A (AurA) inhibitor (antagonist) with IC50 of 12.3 nM that was developed to overcome the BCR-ABL-T315I resistance mutation in leukemia. |
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V98005 | AURKA against 1 | AURKA anti-1 (compound Ac13) is an inhibitor of Aurora kinase (AURKA) (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-tumor cell proliferation activity. | |
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V88590 | AurkA allosteric-IN-1 | AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM), which inhibits the catalytic activity and non-catalytic functions of Aurora A. | |
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V88592 | AURKA-IN-1 | AURKA-IN-1 (compound 9) is a cell-active covalent AURKA inhibitor. | |
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V88594 | Aurkin A | 1534060-58-6 | Aurkin A is an allosteric inhibitor that inhibits the interaction between Aurora A Kinase (also known as Aurka) and TPX2 by targeting the TPX2 binding site (Kd=3.77 μM). |
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V78293 | Aurora A inhibitor 3 | Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with IC50 of 0.78 μM. | |
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V75830 | Aurora kinase inhibitor-11 | 923946-98-9 | Aurora kinase inhibitor-11 (compound 25) is an inhibitor (blocker/antagonist) of Aurora Kinase with IC50 of 0.14 μM. |
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V78294 | Aurora kinase inhibitor-12 | AurorKinase Inhibitor-12 (Compound 1a) is an inhibitor (blocker/antagonist) of aurorKinase, a key enzyme involved in tumor growth. | |
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V52376 | Aurora Kinases-IN-3 | 2840558-83-8 | Aurora Kinases-IN-3 (Compound 15a) is an orally bioactive AURKB inhibitor that induces AURKB inhibitory activity by disrupting the mitotic localization of AURKB rather than inhibiting its phosphorylation of H3 at Ser10. |
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V55049 | Aurora Kinases-IN-4 | 2877011-84-0 | Aurora Kinases-IN-4 (Compound 11c) is a covalent ATP-competitive aurora kinase A inhibitor (IC50= 1.7 nM). |
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V2345 | Aurora Kinase Inhibitor II | 331770-21-9 | AurorKinase inhibitor-2 is a selective and ATP-competitive AurorKinase inhibitor (antagonist) with IC50s of 310 nM and 240 nM for Aurora A and Aurora B respectively. |
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V4055 | Aurora Kinase Inhibitor III | 879127-16-9 | Aurora kinase inhibitor III, a 2,4-dianilinopyrimidine compound, is a novel, potent, highly selective, cell-permeable and ATP-competitive inhibitor of aurora related kinase (ARK) with IC50 of 42 nM for Aurora A kinase. |
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V88595 | Binucleine 2 | 220088-42-6 | Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki=0.36 μM), which is involved in cell division. |
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V52289 | CD532 | 1639009-81-6 | CD532 is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM. |
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V53099 | CD532 hydrochloride | 2926498-81-7 | CD532 HCl is a potent Aurora A kinase inhibitor (antagonist) with IC50 of 45 nM. |
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V94934 | Cenisertib benzoate | 1145859-64-8 | Cenisertib (AS-703569) benzoate is an ATP-competitive multikinase inhibitor that inhibits the activities of Aurora-kinase-A/B, ABL1, AKT, STAT5, and FLT3. |
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V88589 | DBPR728 | 2702965-64-6 | DBPR728 is an acyl prodrug of 6K465 that carries fewer hydrogen bond donors. |