The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C).Aurora kinases regulate a variety of cell cycle-related processes and are necessary for the assembly and operation of the bipolar spindle during the mitotic and meiotic phases.
While Aurora-A, Aurora-B, and Aurora-C have very similar subcellular localizations and functions during mitosis, they also share a highly conserved kinase domain. While Aurora-B and Aurora-C are necessary for condensation, attachment to kinetochores, and alignment of chromosomes during (pro-)metaphase and cytokinesis, Aurora-A primarily regulates centrosome maturation and bipolar spindle assembly. All Aurora kinase members play oncogenic roles related to their mitotic activity and support the survival and growth of cancer cells in human tumors. Researchers studying cancer have become interested in inhibitors that target Aurora kinases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V104176 | (Rac)-Aurora A/PKC-IN-1 | 2143100-98-3 | (Rac)-Aurora A/PKC-IN-1 (compound 2e) is an orally available inhibitor of Aurora A and PKC (α, β1, β2, and θ) kinases. |
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V75831 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B | 154022-51-2 | 11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester analogue of Tenacienin B, which can be extracted from Garcinia cambogia (MTC). |
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V113579 | 5-Bromothiazol-2-amine | 3034-22-8 | 5-Bromothiazol-2-amine (compound 54) is a simple amine compound. |
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V97440 | AJI-100 | 844435-10-5 | AJI-100 is a dual-target inhibitor of Aurora Kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. |
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V97418 | AJI-214 | 1395886-20-0 | AJI-214 is a dual-target inhibitor of Aurora Kinase A and JAK2. It inhibits T cell mitosis and cell polarity by directly blocking Aurora Kinase A, and inhibits STAT3 phosphorylation by inhibiting JAK2 activation, thereby reducing TH1 and TH17 cell differentiation. It can be used to regulate immune responses and prevent graft-versus-host disease (GVHD). |
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V2332 | AKI603 | 1432515-73-5 | AKI603 is an AurorKinase A (AurA) inhibitor (antagonist) with IC50 of 12.3 nM that was developed to overcome the BCR-ABL-T315I resistance mutation in leukemia. |
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V116927 | AurAP14 | AurAP14 is an Aurora A PROTAC degrader (DC50 = 120 nM). | |
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V98005 | AURKA against 1 | AURKA anti-1 (compound Ac13) is an inhibitor of Aurora kinase (AURKA) (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-tumor cell proliferation activity. | |
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V88590 | AurkA allosteric-IN-1 | AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM), which inhibits the catalytic activity and non-catalytic functions of Aurora A. | |
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V88592 | AURKA-IN-1 | AURKA-IN-1 (compound 9) is a cell-active covalent AURKA inhibitor. | |
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V118258 | AURKA-IN-3 | AURKA-IN-3 (compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. | |
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V111836 | AURKA-IN-4 | 89575-11-1 | AURKA-IN-4 (compound 13) is a capsaicin-derived inhibin ligand and an AURKA inhibitor. |
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V88594 | Aurkin A | 1534060-58-6 | Aurkin A is an allosteric inhibitor that inhibits the interaction between Aurora A Kinase (also known as Aurka) and TPX2 by targeting the TPX2 binding site (Kd=3.77 μM). |
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V78293 | Aurora A inhibitor 3 | Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with IC50 of 0.78 μM. | |
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V104753 | Aurora A inhibitor 4 | 371224-09-8 | Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A with GI50 of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively. |
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V117045 | Aurora A-IN-5 | Aurora A-IN-5 is a highly effective and selective Aurora A inhibitor (IC50 = 0.02 μM), with a selectivity for Aurora A that is 362 times higher than that for Aurora B. | |
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V75830 | Aurora kinase inhibitor-11 | 923946-98-9 | Aurora kinase inhibitor-11 (compound 25) is an inhibitor (blocker/antagonist) of Aurora Kinase with IC50 of 0.14 μM. |
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V78294 | Aurora kinase inhibitor-12 | AurorKinase Inhibitor-12 (Compound 1a) is an inhibitor (blocker/antagonist) of aurorKinase, a key enzyme involved in tumor growth. | |
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V119171 | Aurora kinase ligand-1 | 1907679-70-2 | Aurora kinase ligand-1 (compound I-4) is an Aurora kinase B (AURKB) PROTAC ligand. |
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V118602 | Aurora kinase-IN-8 | 1911629-44-1 | Aurora kinase-IN-8 is an orally effective Aurora kinase inhibitor. |
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