A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V118828 | (R)-Etodolac | 87226-41-3 | (R)-Etoduolic acid is the enantiomer of the nonsteroidal anti-inflammatory drug eosin, which can inhibit the transcriptional repression of β-catenin. |
|
V122314 | (Z)-Zolucatetide | (Z)-Zolucatetide is a β-catenin inhibitor with an IC50 ≤50 nM. | |
|
V118780 | 2,5-Epidithia-3,6-dioxopiperazine | 21056-79-1 | 2,5-Epithia-3,6-dioxapiperazine (Formula 15) is a derivative of epithia-dioxapiperazine (ETP). |
|
V128449 | AKT-IN-28 | 3099809-16-9 | AKT-IN-28 is an Akt allosteric inhibitor and a derivative of shikonin. |
|
V79395 | Anti-inflammatory agent 60 | Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production with IC50 of 12.95 μM. | |
|
V88157 | Antitumor agent-171 | 3003004-76-7 | Antitumor agent-171 (Compound 35) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 1.61 μM. |
|
V88158 | Antitumor agent-172 | 3027905-74-1 | Antitumor agent-172 (Compound 28) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 3.92 μM. |
|
V88138 | aStAx-35R | 1418863-17-8 | aStAx-35R is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. |
|
V88137 | aStAx-35R TFA | aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. | |
|
V98486 | BC21 | 691005-38-6 | BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor, which effectively inhibits the binding of β-catenin to Tcf4-derived peptides with IC50 of 5 μM. |
|
V79819 | BMP agonist 1 | BMP agonist 1 (compound 2 b) is a small molecule agonist of bone morphogenetic protein (BMP). | |
|
V80070 | CDK8-IN-11 hydrochloride | CDK8-IN-11 HCl is a potent and specific inhibitor of CDK8 with IC50 of 46 nM. | |
|
V88153 | CGK012 | 2044497-76-7 | CKG012 is an inhibitor of the Wnt/βcatenin signaling pathway. |
|
V132500 | Cryptolepine | 480-26-2 | Cryptolepine is an orally effective pleiotropic alkaloid with various effects, including anticancer, antibacterial, antiviral, antimalarial, anti-inflammatory, hypoglycemic, and analgesic properties. |
|
V133319 | DCEM1 | 878949-21-4 | DCEM1 binds to heat shock protein 60 (HSP60), inhibiting the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. |
|
V86081 | E722-2648 | 931963-55-2 | E722-2648 is a potent inhibitor of β-catenin/BCL9 complex. |
|
V110358 | E722-2648 TFA | E722-2648 TFA is a potent inhibitor of the β-catenin/BCL9 complex. | |
|
V135501 | EXQ-2d | EXQ-2d is a tankyrase inhibitor that inhibits TNKS1 and TNKS2, with IC50 values of 48.8 nM and 13.8 nM, respectively (pIC50 values of 7.31 and 7.86, respectively). | |
|
V136369 | fStAx-35R TFA | fStAx-35R TFA is a hydrocarbon cross-linked peptide. | |
|
V136602 | Getacatetide | 2775373-65-2 | Getacatetide is a peptide-based Wnt/β-catenin inhibitor that can be used in research on solid tumors. |
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