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β-catenin

β-catenin

A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).

β-catenin related products

Structure Cat No. Product Name CAS No. Product Description
Anti-inflammatory agent 60 V79395 Anti-inflammatory agent 60 Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production with IC50 of 12.95 μM.
Antitumor agent-171 V88157 Antitumor agent-171 3003004-76-7 Antitumor agent-171 (Compound 35) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 1.61 μM.
Antitumor agent-172 V88158 Antitumor agent-172 3027905-74-1 Antitumor agent-172 (Compound 28) is an inhibitor of β-catenin/BCL9 interaction with IC50 of 3.92 μM.
aStAx-35R V88138 aStAx-35R 1418863-17-8 aStAx-35R is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling.
aStAx-35R TFA V88137 aStAx-35R TFA aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling.
BMP agonist 1 V79819 BMP agonist 1 BMP agonist 1 (compound 2 b) is a small molecule agonist of bone morphogenetic protein (BMP).
CDK8-IN-11 hydrochloride V80070 CDK8-IN-11 hydrochloride CDK8-IN-11 HCl is a potent and specific inhibitor of CDK8 with IC50 of 46 nM.
CGK012 V88153 CGK012 2044497-76-7 CKG012 is an inhibitor of the Wnt/βcatenin signaling pathway.
E722-2648 V86081 E722-2648 931963-55-2
hCA/Wnt/β-catenin-IN-1 V78739 hCA/Wnt/β-catenin-IN-1 hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor (blocker/antagonist) of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII).
IR-251 V80395 IR-251 IR-251 is a mitochondria-targeted near-infrared fluorescent probe.
KY1022 V67517 KY1022 1029721-36-5 KY1022 is a small molecule that destabilizes Ras by targeting the Wnt/β-catenin pathway.
Miclxin (DS-37262926) V51021 Miclxin (DS-37262926) 2494198-61-5 Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involved in Wnt signaling.
Nefopam-d3 hydrochloride (Fenazoxine-d3 (hydrochloride)) V67510 Nefopam-d3 hydrochloride (Fenazoxine-d3 (hydrochloride)) 1346603-30-2 Nefopam-d3 ( HCl) is the deuterated form of Nefopam HCl.
NF764 V88156 NF764 NF764 is a potent β-catenin (CTNNB1) degrader.
NLS-StAx-h TFA V80955 NLS-StAx-h TFA NLS-StAx-h TFA is a selective, cell-permeable (penetrable), immobilized peptide inhibitor of Wnt signaling with IC50 of 1.4 μM.
NRX-103094 V67503 NRX-103094 2763260-36-0 NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/Ser37 β-catenin and β-TrCP with EC50 of 62 nM and a Kd of 0.6 nM.
NRX-103095 V67506 NRX-103095 2763260-38-2 NRX-103095 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP.
NRX-252114 V67505 NRX-252114 2763260-39-3 NRX-252114 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin and β-TrCP with EC50 of 6.5 nM and a Kd of 0.4 nM.
NRX-252262 V69186 NRX-252262 2438637-61-5 NRX-252262 is a potent enhancer of the interaction between β-Catenin and the homologous E3 ligase SCFβ-TrCP, which can promote the degradation of β-catenin with EC50 of 3.8 nM.
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