A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79395 | Anti-inflammatory agent 60 | Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production with IC50 of 12.95 μM. | |
|
V79819 | BMP agonist 1 | BMP agonist 1 (compound 2 b) is a small molecule agonist of bone morphogenetic protein (BMP). | |
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V80070 | CDK8-IN-11 hydrochloride | CDK8-IN-11 HCl is a potent and specific inhibitor of CDK8 with IC50 of 46 nM. | |
|
V78739 | hCA/Wnt/β-catenin-IN-1 | hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor (blocker/antagonist) of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). | |
|
V80395 | IR-251 | IR-251 is a mitochondria-targeted near-infrared fluorescent probe. | |
|
V67517 | KY1022 | 1029721-36-5 | KY1022 is a small molecule that destabilizes Ras by targeting the Wnt/β-catenin pathway. |
|
V51021 | Miclxin (DS-37262926) | 2494198-61-5 | Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involved in Wnt signaling. |
|
V67510 | Nefopam-d3 hydrochloride (Fenazoxine-d3 (hydrochloride)) | 1346603-30-2 | Nefopam-d3 ( HCl) is the deuterated form of Nefopam HCl. |
|
V80955 | NLS-StAx-h TFA | NLS-StAx-h TFA is a selective, cell-permeable (penetrable), immobilized peptide inhibitor of Wnt signaling with IC50 of 1.4 μM. | |
|
V67503 | NRX-103094 | 2763260-36-0 | NRX-103094 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/Ser37 β-catenin and β-TrCP with EC50 of 62 nM and a Kd of 0.6 nM. |
|
V67506 | NRX-103095 | 2763260-38-2 | NRX-103095 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP. |
|
V67505 | NRX-252114 | 2763260-39-3 | NRX-252114 is a potent enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin and β-TrCP with EC50 of 6.5 nM and a Kd of 0.4 nM. |
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V69186 | NRX-252262 | 2438637-61-5 | NRX-252262 is a potent enhancer of the interaction between β-Catenin and the homologous E3 ligase SCFβ-TrCP, which can promote the degradation of β-catenin with EC50 of 3.8 nM. |
|
V67507 | NRX-2663 | 2763260-34-8 | NRX-2663 is an enhancer of the interaction between β-catenin and the homologous E3 ligase SCFβ-TrCP, enhancing the binding of β-catenin to β-TrCP with EC50 of 22.9 µM and a Kd of 54.8 nM. |
|
V67512 | Pterostilbene-isothiocyanate (PTER-ITC) | 1616974-29-8 | Pterostilbene-isothiocyanate (PTER-ITC) has potent anti-cancer activities in vitro. |
|
V67514 | UU-T01 | 1417162-83-4 | UU-T01 is a selective inhibitor of β-Catenin/T-cell factor 4 protein interaction (β-catenin/Tcf PPI) with a Ki of 3.14 µM. |
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V51014 | WAY-331955 | 901736-76-3 | beta-catenin modulator |
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V50983 | WAY-332023 | 1053086-89-7 | β-Catenin modulator-1 (IIa-650) is a β-Catenin modulator used in cancer-related research. |
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V50984 | WAY-332034 | 1015858-17-9 | β-Catenin modulator-3 (compound IIa-112) is an oxazole and thiazole compound that is a potent and specific β-Catenin modulator. |
|
V51001 | WAY-332060 | 1015858-82-8 | beta-catenin modulator |
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