The most notable HSP (Heat Shock Proteins) are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP are a group of proteins induced by heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2713 | KRIBB11 | 342639-96-7 | KRIBB11, a novel and potent inhibitor ofHeat shock factor 1 (HSF1), abolishes the heat shock-induced luciferase activity with an IC50 of 1.2 μM. |
|
V15763 | Pimitespib (TAS-116) | 1260533-36-5 | Pimitespib (TAS-116) is a novel, potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta [HSP90α/HSP90β] with anticancer activity. |
|
V3776 | PU-H71 | 873436-91-0 | This product has been discontinued from InvivoChem. |
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