Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as -CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian -CA isoforms.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73752 | (E)-Dehydrodiconiferyl alcohol | 528814-97-3 | (E)-Dehydrodiconiferyl alcohol is an inhibitor (blocker/antagonist) of hCA IX and hCA XII. |
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V81854 | 5-Methyluridine-d4 | 82845-85-0 | 5-Methyluridine-d4 is the deuterium labelled form of 5-Methyluridine. |
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V73760 | Benzolamide (CL11366) | 3368-13-6 | Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor (antagonist) with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ respectively. |
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V73749 | Brinzolamide-d5 (AL-4862-d5) | 1217651-02-9 | Brinzolamide-d5 is the deuterated form of Brinzolamide. |
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V78551 | Brinzolamide-d5 hydrochloride (AL-4862-d5 hydrochloride) | Brinzolamide-d5 ( HCl) is the deuterated form of Brinzolamide HCl. | |
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V77561 | CA inhibitor 2 | CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50= 0.033 μM). | |
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V79928 | CAII-IN-1 | CAII-IN-1 (compound 3n) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 10.3 µM for bovine CA-II. | |
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V78605 | CAII-IN-2 | CAII-IN-2 (compound 3g) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 12.1 µM for bovine CA-II. | |
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V80009 | CAII-IN-3 | CAII-IN-3 (compound 3h), a thiosemicarbazone analogue, is a potent carbonic anhydrase II (CA-II) inhibitor (antagonist) with IC50 of 13.4 µM against bovine CA-II. | |
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V73766 | CAIX/CAXII-IN-1 | 2439165-37-2 | Compound 9 was most potent against tumor-specific CA IX/CA XII (KI=29.1 and 8.8 nM), making it possible to evaluate its cytotoxic effect and selectivity against HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro , and its IC50s against tumor cells are 1.78, 1.94 and 3.07μM respectively, indicating that it has obvious cytotoxic effect. |
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V73747 | Carbonic anhydrase (carbonic anhydrase; EC 4.2.1.1) | 9001-03-0 | Carbonic anhydrases are ubiquitous zinc-containing metalloenzymes in prokaryotes and eukaryotes. |
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V73763 | Carbonic anhydrase inhibitor 12 | 2883451-38-3 | Carbonic anhydrase inhibitor 12 is a potent inhibitor of CA II and also exhibits inhibitory effect against CA I (Kis of CA II and CA I are 1.72 nM and 271 nM, respectively). |
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V78640 | Carbonic anhydrase inhibitor 15 | Carbonic anhydrase inhibitor 15 (Compound 8) is a carbonic anhydrase inhibitor (Ki: 8.5 nM for hCA II). | |
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V73759 | Carbonic anhydrase inhibitor 2 | 2758231-43-3 | Carbonic anhydrase inhibitor 2 (compound 7c) is a carbonic anhydrase II (carbonic anhydrase II) inhibitor that can reduce intraocular pressure in glaucoma rabbits. |
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V73767 | Carbonic anhydrase inhibitor 3 | 2758231-56-8 | Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II (carbonic anhydrase II) inhibitor that can reduce intraocular pressure in glaucoma rabbits. |
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V73754 | Carbonic anhydrase inhibitor 4 | 2764889-93-0 | Carbonic anhydrase inhibitor 4 is a light probe/inhibitor of carbonic anhydrase. |
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V14925 | Dorzolamide | 120279-96-1 | Dorzolamide (L671152;MK507; L671152; MK507; Trusopt) is a CAI (carbonic anhydrase inhibitors) approved for use asan anti-glaucoma agent. |
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V79712 | hCA IX-IN-2 | hCA IX-IN-2 is a potent and specific inhibitor of hCA IX with a KI of 32.1 nM. | |
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V80292 | hCA XII-IN-6 | hCA XII-IN-6 (compound 4d) is a potent hCA XII inhibitor (antagonist) with Ki of 84.2 nM. | |
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V79713 | hCA/VEGFR-2-IN-1 | hCA/VEGFR-2-IN-1 is a potent bicarbonic anhydrase (CA) IX/XII with Kis of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. |
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