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Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.

The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as -CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian -CA isoforms.

Carbonic Anhydrase related products

Structure Cat No. Product Name CAS No. Product Description
(E)-Dehydrodiconiferyl alcohol V73752 (E)-Dehydrodiconiferyl alcohol 528814-97-3 (E)-Dehydrodiconiferyl alcohol is an inhibitor (blocker/antagonist) of hCA IX and hCA XII.
4-Acetylphenylboronic acid V87327 4-Acetylphenylboronic acid 149104-90-5 4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrase II (CA II) with IC50 of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II), respectively.
5-Methyluridine-d4 V81854 5-Methyluridine-d4 82845-85-0 5-Methyluridine-d4 is the deuterium labelled form of 5-Methyluridine.
Anti-inflammatory agent 67 V84398 Anti-inflammatory agent 67
Anti-inflammatory agent 68 V84382 Anti-inflammatory agent 68
Antitumor agent-163 V87344 Antitumor agent-163 Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) for carbonic anhydrase IX (CAIX).
AV22-149 V94590 AV22-149 AV22-149 (Compound 22) is a carbonic anhydrase inhibitor.
Benzolamide (CL11366) V73760 Benzolamide (CL11366) 3368-13-6 Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor (antagonist) with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ respectively.
Brinzolamide-d5 (AL-4862-d5) V73749 Brinzolamide-d5 (AL-4862-d5) 1217651-02-9 Brinzolamide-d5 is the deuterated form of Brinzolamide.
Brinzolamide-d5 hydrochloride (AL-4862-d5 hydrochloride) V78551 Brinzolamide-d5 hydrochloride (AL-4862-d5 hydrochloride) Brinzolamide-d5 ( HCl) is the deuterated form of Brinzolamide HCl.
CA inhibitor 2 V77561 CA inhibitor 2 CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50= 0.033 μM).
CA Ⅱ-IN-1 V93228 CA Ⅱ-IN-1 CA Ⅱ-IN-1 (Compound 2i) is a CA Ⅱ isozyme inhibitor with IC50 of 0.44 µM.
CA/MAO-B-IN-1 V87336 CA/MAO-B-IN-1 CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor of human CA and MAO-B with IC50 of 8.8 and 7.0 nM, respectively.
CAII-IN-1 V79928 CAII-IN-1 CAII-IN-1 (compound 3n) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 10.3 µM for bovine CA-II.
CAII-IN-2 V78605 CAII-IN-2 CAII-IN-2 (compound 3g) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 12.1 µM for bovine CA-II.
CAII-IN-3 V80009 CAII-IN-3 CAII-IN-3 (compound 3h), a thiosemicarbazone analogue, is a potent carbonic anhydrase II (CA-II) inhibitor (antagonist) with IC50 of 13.4 µM against bovine CA-II.
CAIX/CAXII-IN-1 V73766 CAIX/CAXII-IN-1 2439165-37-2 Compound 9 was most potent against tumor-specific CA IX/CA XII (KI=29.1 and 8.8 nM), making it possible to evaluate its cytotoxic effect and selectivity against HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro , and its IC50s against tumor cells are 1.78, 1.94 and 3.07μM respectively, indicating that it has obvious cytotoxic effect.
CAIX/CAXII-IN-2 V87337 CAIX/CAXII-IN-2 CAIX/CAXII-IN-2 (compound 23) is a CAIX/CAXII inhibitor with Ki values of 8.9 nM and 5.3 nM for CAIX/CAXII, respectively.
CAIX/CAXII-IN-3 V94840 CAIX/CAXII-IN-3 CAIX/CAXII-IN-3 (Compound 11) is an inhibitor of CAIX/CAXII with IC50 value less than 65 nM.
Carbonic anhydrase (carbonic anhydrase; EC 4.2.1.1) V73747 Carbonic anhydrase (carbonic anhydrase; EC 4.2.1.1) 9001-03-0 Carbonic anhydrases are ubiquitous zinc-containing metalloenzymes in prokaryotes and eukaryotes.
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