Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2 + H2O ⇋ HCO3- + H+. Eight genetically distinct families of carbonic anhydrase enzymes (CAs) have so far been identified. Numerous physiological and pathological processes involve carbonic anhydrases. Many of them have the potential to be inhibited as effective therapeutic targets for the treatment of a variety of diseases, including oedema, glaucoma, obesity, cancer, epilepsy, and osteoporosis.
The carbonic anhydrase reaction is involved in a variety of physiological and pathological processes, including bone resorption, calcification, tumorigenicity, pH and CO2 homeostasis, electrolyte secretion in various tissues and organs, and respiration and transport of CO2 and bicarbonate between metabolizing tissues and lungs. Zn2+ metalloproteins known as -CAs are found in a wide range of organisms, including plants, prokaryotes, fungi, algae, and protozoa. Numerous diseases, including glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, arthritis, neurodegeneration, etc., have been linked to sixteen mammalian -CA isoforms.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73752 | (E)-Dehydrodiconiferyl alcohol | 528814-97-3 | (E)-Dehydrodiconiferyl alcohol is an inhibitor (blocker/antagonist) of hCA IX and hCA XII. |
|
V87327 | 4-Acetylphenylboronic acid | 149104-90-5 | 4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrase II (CA II) with IC50 of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II), respectively. |
|
v107920 | 4-Chloro-5-sulphamoylbenzo | 1205-30-7 | |
|
V81854 | 5-Methyluridine-d4 | 82845-85-0 | 5-Methyluridine-d4 is the deuterium labelled form of 5-Methyluridine. |
|
V105143 | AChE/hCA I-IN-1 | 155140-19-5 | |
|
V84398 | Anti-inflammatory agent 67 | ||
|
V84382 | Anti-inflammatory agent 68 | ||
|
V87344 | Antitumor agent-163 | Antitumor agent-163 (Compound 3) is a photosensitizer used in Molecular-Targeted Photodynamic Therapy (MT-PDT) for carbonic anhydrase IX (CAIX). | |
|
V94590 | AV22-149 | AV22-149 (Compound 22) is a carbonic anhydrase inhibitor. | |
|
V73760 | Benzolamide (CL11366) | 3368-13-6 | Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor (antagonist) with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ respectively. |
|
V73749 | Brinzolamide-d5 (AL-4862-d5) | 1217651-02-9 | Brinzolamide-d5 is the deuterated form of Brinzolamide. |
|
V78551 | Brinzolamide-d5 hydrochloride (AL-4862-d5 hydrochloride) | Brinzolamide-d5 ( HCl) is the deuterated form of Brinzolamide HCl. | |
|
V77561 | CA inhibitor 2 | CA inhibitor 2 (Compound 4H) is a carbonic anhydrase inhibitor (IC50= 0.033 μM). | |
|
V104495 | CA IX-IN-3 | 333413-02-8 | |
|
V105137 | CA IX/VEGFR-2-IN-3 | ||
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V93228 | CA Ⅱ-IN-1 | CA Ⅱ-IN-1 (Compound 2i) is a CA Ⅱ isozyme inhibitor with IC50 of 0.44 µM. | |
|
V87336 | CA/MAO-B-IN-1 | CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor of human CA and MAO-B with IC50 of 8.8 and 7.0 nM, respectively. | |
|
V79928 | CAII-IN-1 | CAII-IN-1 (compound 3n) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 10.3 µM for bovine CA-II. | |
|
V78605 | CAII-IN-2 | CAII-IN-2 (compound 3g) is a thiosemicarbazide analogue and a potent and specific carbonic anhydrase-II (CA-II) inhibitor (antagonist) with IC50 of 12.1 µM for bovine CA-II. | |
|
V80009 | CAII-IN-3 | CAII-IN-3 (compound 3h), a thiosemicarbazone analogue, is a potent carbonic anhydrase II (CA-II) inhibitor (antagonist) with IC50 of 13.4 µM against bovine CA-II. |
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