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GCGR

GCGR

The G protein-coupled receptor family, which includes the glucagon receptor (GCGR), is crucial for regulating blood sugar levels. The class B G-protein coupled family of receptors includes the glucagon receptor, a 62 kDa protein that is activated by glucagon and coupled to G alpha i, Gs, and to a lesser extent G alpha q. Adenylate cyclase is activated and intracellular cAMP levels are raised when the receptor is stimulated. The GCGR gene in humans is responsible for encoding the glucagon receptor. The liver and kidneys are the primary sites of glucagon receptor expression, with smaller amounts of these receptors also present in the heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

GCGR related products

Structure Cat No. Product Name CAS No. Product Description
[Des-His1,Glu9] Glucagon V74594 [Des-His1,Glu9] Glucagon 110121-11-4 [Des-His1,Glu9] Glucagon is a potent peptide antagonist of the glucagon receptor system.
[Des-His1,Glu9]-Glucagon amide TFA V77345 [Des-His1,Glu9]-Glucagon amide TFA [Des-His1,Glu9]-Glucagon amide TFA is a potent peptide antagonist of the glucagon receptor with a pA2 value of 7.2.
A8SGLP-1 V74593 A8SGLP-1 753024-08-7 A8SGLP-1 is an orally bioactive GLP-1 analog in which alanine at position 8 is replaced by serine.
A8SGLP-1 TFA V77707 A8SGLP-1 TFA A8SGLP-1 TFA is an orally bioactive GLP-1 analog in which alanine at position 8 is replaced by serine.
AMG133 peptide payload V93640 AMG133 peptide payload The AMG133 peptide payload is a GLP-1 agonist and can be used as a peptide linker conjugate of AMG133.
AMG133 peptide payload TFA V128676 AMG133 peptide payload TFA AMG133 peptide payload TFA is a GLP-1 analog agonist peptide.
Avexitide V33194 Avexitide 133514-43-9 Avexitide [Exendin-3 (9-39)] is a novel, competitive and peptidic antagonist of glucagon-like peptide-1 (GLP-1) receptor with a Kd of 1.7 nM at cloned human GLP-1 receptors.
Bay 55-9837 V51719 Bay 55-9837 463930-25-8 VPAC2 agonist
Bay 55-9837 TFA V78347 Bay 55-9837 TFA Bay 55-9837 TFA is a potent and selective VPAC2 agonist/activator with a Kd of 0.65 nM.
BETP V33070 BETP 1371569-69-5 BETP is a novel and potent PAM (positive allosteric modulator) and partial agonist of glucagon-like peptide-1 (GLP-1) receptor (EC50= 0.66 μM) with antidiabetic effects.
Biotinyl-Glucagon (1-29), human, bovine, porcine V78466 Biotinyl-Glucagon (1-29), human, bovine, porcine Biotinyl-Glucagon (1-29), human, bovine, porcine is a biomarker of Glucagon, a peptide hormone produced by pancreatic alpha cells that increases the concentration of glucose and fatty acids in the blood.
Cotadutide (MEDI0382) V74587 Cotadutide (MEDI0382) 1686108-82-6 Cotadutide (MEDI0382) is a potent dual glucagon-like peptide-1 (GLP-1) and glucagon receptor (GCGR) agonist/activator with EC50s of 6.9 pM and 10.2 pM, respectively.
DA-302168S V133157 DA-302168S 2969158-02-7 DA-302168S is an orally effective selective GLP-1 receptor agonist with an EC50 value of 1.32 nM.
Dapiglutide (ZP7570) V74568 Dapiglutide (ZP7570) 2296814-85-0 Dapiglutide (ZP7570) is a long-acting glucagon-like peptide 1 receptor (GLP-1R)/glucagon-like peptide 2 receptor (GLP-2R) dual agonist.
Des His1, Glu8 Exendin-4 V79079 Des His1, Glu8 Exendin-4 Des His1, Glu8 Exendin-4 is a potent glucagon-like peptide-1 receptor (GLP-1-R) antagonist.
Elsiglutide (ZP1846) V74581 Elsiglutide (ZP1846) 914009-84-0 Elsiglutide (ZP1846) is a GLP-2 analog and an orally bioactive and selective GLP-2 receptor agonist that increases cell proliferation/growth and reduces intestinal cell apoptosis (apoptosis).
Exendin (5-39) V74595 Exendin (5-39) 196109-27-0 Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1 receptor) receptor antagonist.
Exendin-3/4 (59-86) V74580 Exendin-3/4 (59-86) 1263874-37-8 Exendin-3/4 (59-86) is an Exendin-4 peptide analogue.
Exendin-4-Lys-azide TFA V135495 Exendin-4-Lys-azide TFA Exendin-4-Lys-azide TFA is an azide derivative of Exendin-4-Lys-azide, and can be used in coupling/click chemistry.
FC382K10W15 TFA V79393 FC382K10W15 TFA FC382K10W15 TFA is a glucagon analog and GLP-1R/GCGR agonist.
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