There are 13 species in the genus Enterovirus (EV), which is a member of the Picornaviridae family, seven of which are viruses that affect humans. Four of the species are coxsackievirus (EV)-A, which includes CV-A6, CV-A10, CV-A16, and EV-A71, EV-B, which includes CV-B viruses, echoviruses (ECHO), and CV-A9, EV-C, which includes PV and CV-A21, and EV-D, which includes EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B, and RV-C, which collectively comprise more than 100 distinct RVs with different numbers. Numerous clinical conditions, such as poliomyelitis, meningitis and encephalitis, hand, foot, and mouth disease, acute flaccid paralysis, diarrhea, myocarditis, and respiratory illness, can be brought on by enterovirus infection.
Positive-sense, single-stranded RNA viruses with an icosahedral capsid that are small, nonenveloped enteroviruses. A single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, and 3D), and a number of functional processing intermediates is encoded by the genome of approximately 7.5 kb. The development of antiviral drugs is attracted to the viral nonstructural proteins, particularly the protease 3Cpro and the RNA-dependent RNA polymerase 3Dpol.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54162 | (Rac)-Golgicide A ((Rac)-GCA) | 1005036-73-6 | (Rac)-Golgicide A is the racemate of Golgicide A. |
|
V88230 | 2-Hydroxytetradecanoic acid | 2507-55-3 | 2-Hydroxytetradecanoic Acid is a hydroxy fatty acid that inhibits the cleavage between enterovirus capsid proteins VP4 and VP2. |
|
V34272 | 5-Hydroxy-6,7-dimethoxylflavone | 740-33-0 | 5-Hydroxy-6,7-dimethoxylflavone is natural product of the flavonoid class. |
|
V34994 | Antiviral agent 23 | 35940-03-5 | antiviral compound 23 (compound 11b) is an antiviral compound against enterovirus 71 (EV71) with EC50 of 94 nM. |
|
V34993 | Antiviral agent 24 | 23661-03-2 | antiviral compound 24 is an effective antiviral compound with EC50s of 0.101, 19.9, and 91.2 µM against EV71, CVA21, and EV68, respectively. |
|
V88233 | AZ5385 | 848439-89-4 | AZ5385 is an EGFR-tyrosine kinase inhibitor. |
|
V88234 | BTA-188 | 314062-80-1 | BTA-188 is a pyridazinyl oxime ether that is an orally active, potent inhibitor of rhinovirus (HRV) and enterovirus (EV) 71. |
|
V52991 | cis-Resveratrol (cis-resveratrol) | 61434-67-1 | cis-Resveratrol has significant antiviral effect. |
|
V78808 | Citrullinated LL-37 4cit | Citrullinated LL-37 3cit is a citrullinated LL-37 peptide. | |
|
V88231 | EV-A71-IN-2 | EV-A71-IN-2 (compound 6c) is an anti-enterovirus A71 agent with EC50 values of 0.29 μM and 1.66 μM in EV-A71-MRC-5 cells and EV-A71-RD cells, respectively. | |
|
V0188 | Golgicide A (GCA) | 1139889-93-2 | Golgicide A(GCA), aquinoline compound,is a cell-permeable, potent and rapidly reversible inhibitor of GBF1, which is one of the guanine nucleotide exchange factors (ArfGEFs). |
|
V52066 | Golgicide A-2 (GCA-2) | 1394285-50-7 | Golgicide A-2 (GCA-2) is an analogue of GCA and is the most active enantiomer of GCA. |
|
V54161 | Methyl 3,4-dihydroxyphenylacetate | 25379-88-8 | Methyl 3,4-dihydroxyphenylacetate is a potent inhibitor of enterovirus 71 (EV71) infection. |
|
V52683 | Pirlindole-d4 | 1801646-26-3 | Pirlindole-d4 is the deuterium labelled form of Pirlindole. |
|
V35124 | WIN 54954 | 107355-45-3 | WIN 54954 is an orally bioactive, broad-spectrum antipicornaviral agent. |
|
V76302 | ZHSI-1 | 2925912-67-8 | ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that can inhibit the replication of EV71/CVA16 and the virus-induced pyroptosis associated with viral pathogenesis. |
|
V34323 | Norwogonin | 4443-09-8 | Norwogonin is extracted from Scutellaria baicalensis Georgi and has anti-enterovirus 71 (EV71) activity with IC50 of 31.83 μg/ml. |
|
V3819 | Pirodavir | 124436-59-5 | Pirodavir (formerly known as R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds. |
|
V2818 | Pleconaril | 153168-05-9 | Pleconaril (also known as VP 63843; Win 63843) is acapsid inhibitor and an antiviral drug that has the potential for the treatment of enterovirus infection and asthma. |
|
V2892 | Pocapavir | 146949-21-5 | Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation to treat neonatal enterovirus sepsis. |
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