There are 13 species in the genus Enterovirus (EV), which is a member of the Picornaviridae family, seven of which are viruses that affect humans. Four of the species are coxsackievirus (EV)-A, which includes CV-A6, CV-A10, CV-A16, and EV-A71, EV-B, which includes CV-B viruses, echoviruses (ECHO), and CV-A9, EV-C, which includes PV and CV-A21, and EV-D, which includes EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B, and RV-C, which collectively comprise more than 100 distinct RVs with different numbers. Numerous clinical conditions, such as poliomyelitis, meningitis and encephalitis, hand, foot, and mouth disease, acute flaccid paralysis, diarrhea, myocarditis, and respiratory illness, can be brought on by enterovirus infection.
Positive-sense, single-stranded RNA viruses with an icosahedral capsid that are small, nonenveloped enteroviruses. A single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, and 3D), and a number of functional processing intermediates is encoded by the genome of approximately 7.5 kb. The development of antiviral drugs is attracted to the viral nonstructural proteins, particularly the protease 3Cpro and the RNA-dependent RNA polymerase 3Dpol.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V54162 | (Rac)-Golgicide A ((Rac)-GCA) | 1005036-73-6 | (Rac)-Golgicide A is the racemate of Golgicide A. |
|
V88230 | 2-Hydroxytetradecanoic acid | 2507-55-3 | 2-Hydroxytetradecanoic Acid is a hydroxy fatty acid that inhibits the cleavage between enterovirus capsid proteins VP4 and VP2. |
|
V126329 | 4-Chlorocinnamaldehyde | 49678-02-6 | 4-Chlorocinnamaldehyde is an antiviral agent. |
|
V34272 | 5-Hydroxy-6,7-dimethoxylflavone | 740-33-0 | 5-Hydroxy-6,7-dimethoxylflavone is natural product of the flavonoid class. |
|
V34994 | Antiviral agent 23 | 35940-03-5 | antiviral compound 23 (compound 11b) is an antiviral compound against enterovirus 71 (EV71) with EC50 of 94 nM. |
|
V34993 | Antiviral agent 24 | 23661-03-2 | antiviral compound 24 is an effective antiviral compound with EC50s of 0.101, 19.9, and 91.2 µM against EV71, CVA21, and EV68, respectively. |
|
V129617 | ATPase-IN-8 | 145294-59-3 | ATPase-IN-8 is an antiviral drug that inhibits the viral non-structural protein 2C, with an IC50 value of 1.4 μM for CV-B3 2C ATPase. |
|
V88233 | AZ5385 | 848439-89-4 | AZ5385 is an EGFR-tyrosine kinase inhibitor. |
|
V88234 | BTA-188 | 314062-80-1 | BTA-188 is a pyridazinyl oxime ether that is an orally active, potent inhibitor of rhinovirus (HRV) and enterovirus (EV) 71. |
|
V52991 | cis-Resveratrol (cis-resveratrol) | 61434-67-1 | cis-Resveratrol has significant antiviral effect. |
|
V78808 | Citrullinated LL-37 4cit | Citrullinated LL-37 3cit is a citrullinated LL-37 peptide. | |
|
V105039 | Cox B-IN-1 | Cox B-IN-1 (7a) has antiviral activity against Coxsackie B virus (Cox B). | |
|
V133301 | DC07090 | 879070-72-1 | DC07090 is a potent, reversible, competitive non-peptide human enterovirus 71 3C protease inhibitor with IC50 and Ki values of 21.72 μM and 23.29 μM, respectively. |
|
V134738 | DTriP-22 | 717098-99-2 | DTriP-22 is a highly effective and low-toxicity inhibitor of enterovirus 71 3D polymerase (EV71 3D polymerase). |
|
V134790 | Dyrk1A-IN-12 | 2243701-11-1 | Dyrk1A-IN-12 is a Dyrk (bispecific tyrosine phosphorylation-regulated kinase 1A) inhibitor. |
|
V106259 | ER-DRI | ER-DRI is a potent peptide inhibitor against EV-A71. | |
|
V88231 | EV-A71-IN-2 | EV-A71-IN-2 (compound 6c) is an anti-enterovirus A71 agent with EC50 values of 0.29 μM and 1.66 μM in EV-A71-MRC-5 cells and EV-A71-RD cells, respectively. | |
|
V135465 | EV-A71-IN-3 | EV-A71-IN-3 is an inhibitor of enterovirus A71 (EV-A71). It targets the internal ribosome entry site (IRES) of EV-A71, inhibits IRES-mediated translation, and inhibits viral replication with an EC50 of 11.96 μM. | |
|
V136385 | Fukinolic acid | 50982-40-6 | Fukinolic acid is a benzyl tartrate that has vasodilatory effects and can inhibit the replication of enterovirus A71 (EV-A71). |
|
V0188 | Golgicide A (GCA) | 1139889-93-2 | Golgicide A(GCA), aquinoline compound,is a cell-permeable, potent and rapidly reversible inhibitor of GBF1, which is one of the guanine nucleotide exchange factors (ArfGEFs). |
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