Enterovirus

Enterovirus

There are 13 species in the genus Enterovirus (EV), which is a member of the Picornaviridae family, seven of which are viruses that affect humans. Four of the species are coxsackievirus (EV)-A, which includes CV-A6, CV-A10, CV-A16, and EV-A71, EV-B, which includes CV-B viruses, echoviruses (ECHO), and CV-A9, EV-C, which includes PV and CV-A21, and EV-D, which includes EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B, and RV-C, which collectively comprise more than 100 distinct RVs with different numbers. Numerous clinical conditions, such as poliomyelitis, meningitis and encephalitis, hand, foot, and mouth disease, acute flaccid paralysis, diarrhea, myocarditis, and respiratory illness, can be brought on by enterovirus infection.

Positive-sense, single-stranded RNA viruses with an icosahedral capsid that are small, nonenveloped enteroviruses. A single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, and 3D), and a number of functional processing intermediates is encoded by the genome of approximately 7.5 kb. The development of antiviral drugs is attracted to the viral nonstructural proteins, particularly the protease 3Cpro and the RNA-dependent RNA polymerase 3Dpol.

Enterovirus related products

Structure Cat No. Product Name CAS No. Product Description
V54162 (Rac)-Golgicide A ((Rac)-GCA) 1005036-73-6
V34272 5-Hydroxy-6,7-dimethoxylflavone 740-33-0 5-Hydroxy-6,7-dimethoxylflavone is natural product of the flavonoid class.
V34994 Antiviral agent 23 35940-03-5
V34993 Antiviral agent 24 23661-03-2
V52991 cis-Resveratrol (cis-resveratrol) 61434-67-1
V78808 Citrullinated LL-37 4cit
V0188 Golgicide A (GCA) 1139889-93-2 Golgicide A(GCA), aquinoline compound,is a cell-permeable, potent and rapidly reversible inhibitor of GBF1, which is one of the guanine nucleotide exchange factors (ArfGEFs).
V52066 Golgicide A-2 (GCA-2) 1394285-50-7
V54161 Methyl 3,4-dihydroxyphenylacetate 25379-88-8
V34323 Norwogonin 4443-09-8 Norwogonin is natural product of the flavonoid class.
V52683 Pirlindole-d4 1801646-26-3
V3819 Pirodavir 124436-59-5 Pirodavir (formerly known as R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds.
V2818 Pleconaril 153168-05-9 Pleconaril (also known as VP 63843; Win 63843) is acapsid inhibitor and an antiviral drug that has the potential for the treatment of enterovirus infection and asthma.
V2892 Pocapavir 146949-21-5 Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation to treat neonatal enterovirus sepsis.
V35124 WIN 54954 107355-45-3
V76302 ZHSI-1 2925912-67-8
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