There are 13 species in the genus Enterovirus (EV), which is a member of the Picornaviridae family, seven of which are viruses that affect humans. Four of the species are coxsackievirus (EV)-A, which includes CV-A6, CV-A10, CV-A16, and EV-A71, EV-B, which includes CV-B viruses, echoviruses (ECHO), and CV-A9, EV-C, which includes PV and CV-A21, and EV-D, which includes EV-D68 and EV-D70. The other three species are rhinoviruses RV-A, RV-B, and RV-C, which collectively comprise more than 100 distinct RVs with different numbers. Numerous clinical conditions, such as poliomyelitis, meningitis and encephalitis, hand, foot, and mouth disease, acute flaccid paralysis, diarrhea, myocarditis, and respiratory illness, can be brought on by enterovirus infection.

Positive-sense, single-stranded RNA viruses with an icosahedral capsid that are small, nonenveloped enteroviruses. A single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A, 2B, 2C, 3A, 3B, and 3D), and a number of functional processing intermediates is encoded by the genome of approximately 7.5 kb. The development of antiviral drugs is attracted to the viral nonstructural proteins, particularly the protease 3Cpro and the RNA-dependent RNA polymerase 3Dpol.

Enterovirus related products

Structure Cat No. Product Name CAS No. Product Description
(Rac)-Golgicide A ((Rac)-GCA) V54162 (Rac)-Golgicide A ((Rac)-GCA) 1005036-73-6 (Rac)-Golgicide A is the racemate of Golgicide A.
5-Hydroxy-6,7-dimethoxylflavone V34272 5-Hydroxy-6,7-dimethoxylflavone 740-33-0 5-Hydroxy-6,7-dimethoxylflavone is natural product of the flavonoid class.
Antiviral agent 23 V34994 Antiviral agent 23 35940-03-5 antiviral compound 23 (compound 11b) is an antiviral compound against enterovirus 71 (EV71) with EC50 of 94 nM.
Antiviral agent 24 V34993 Antiviral agent 24 23661-03-2 antiviral compound 24 is an effective antiviral compound with EC50s of 0.101, 19.9, and 91.2 µM against EV71, CVA21, and EV68, respectively.
cis-Resveratrol (顺式白藜芦醇) V52991 cis-Resveratrol (cis-resveratrol) 61434-67-1 cis-Resveratrol has significant antiviral effect.
Citrullinated LL-37 4cit V78808 Citrullinated LL-37 4cit Citrullinated LL-37 3cit is a citrullinated LL-37 peptide.
Golgicide A (GCA) V0188 Golgicide A (GCA) 1139889-93-2 Golgicide A(GCA), aquinoline compound,is a cell-permeable, potent and rapidly reversible inhibitor of GBF1, which is one of the guanine nucleotide exchange factors (ArfGEFs).
Golgicide A-2 (GCA-2) V52066 Golgicide A-2 (GCA-2) 1394285-50-7 Golgicide A-2 (GCA-2) is an analogue of GCA and is the most active enantiomer of GCA.
Methyl 3,4-dihydroxyphenylacetate V54161 Methyl 3,4-dihydroxyphenylacetate 25379-88-8 Methyl 3,4-dihydroxyphenylacetate is a potent inhibitor of enterovirus 71 (EV71) infection.
Norwogonin V34323 Norwogonin 4443-09-8 Norwogonin is extracted from Scutellaria baicalensis Georgi and has anti-enterovirus 71 (EV71) activity with IC50 of 31.83 μg/ml.
Pirlindole-d4 V52683 Pirlindole-d4 1801646-26-3 Pirlindole-d4 is the deuterium labelled form of Pirlindole.
Pirodavir V3819 Pirodavir 124436-59-5 Pirodavir (formerly known as R 77975) is the prototype of a novel class of broad-spectrum antipicornavirus compounds.
Pleconaril V2818 Pleconaril 153168-05-9 Pleconaril (also known as VP 63843; Win 63843) is acapsid inhibitor and an antiviral drug that has the potential for the treatment of enterovirus infection and asthma.
Pocapavir V2892 Pocapavir 146949-21-5 Pocapavir, formerly known as SCH-48973 and V-073, is a novel, potent, and selective antienterovirus agent that is under clinical investigation to treat neonatal enterovirus sepsis.
WIN 54954 V35124 WIN 54954 107355-45-3 WIN 54954 is an orally bioactive, broad-spectrum antipicornaviral agent.
ZHSI-1 V76302 ZHSI-1 2925912-67-8 ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that can inhibit the replication of EV71/CVA16 and the virus-induced pyroptosis associated with viral pathogenesis.
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