CXCRs (CXC chemokine receptors) are membrane-integral proteins that bind and react to particular members of the CXC chemokine family of cytokines. They belong to a large family of G protein-linked receptors known as seven transmembrane (7-TM) proteins because they span the cell membrane seven times. They are one subfamily of chemokine receptors. CXCR1 through CXCR7 are the seven CXC chemokine receptors that are currently recognized in mammals.The CXC chemokine receptors CXCR1 and CXCR2 recognize CXC chemokines that have an E-L-R amino acid motif right next to their CXC motif. The majority of CXCR3-expressing cells are T lymphocytes. Like CCR5, CXCR4 is the receptor for a chemokine called CXCL12 (also known as SDF-1), and it is used by HIV-1 to enter target cells.The B cell-specific chemokine receptor CXCR5 plays a role in lymphocyte homing and the maturation of healthy lymphoid tissue. Prior to being given the name CXCR6, CXCR6 was known by three different names (STRL33, BONZO, and TYMSTR) because of its chromosomal location and similarity to other chemokine receptors in its gene sequence. CXCR7 was previously known as RDC-1 (an orphan receptor), but after it was discovered that CXCL12 (the ligand for CXCR4) causes chemotaxis in T lymphocytes, this molecule was renamed to CXCR7.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V97414 | (R)-SCH 546738 | 2181148-54-7 | (R)-SCH 546738 is the R version of SCH 546738. |
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V51664 | (R,R)-CXCR2-IN-2 | 1838123-22-0 | CXCR2 antagonist |
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V93059 | (Rac)-SCH 563705 | 2701435-64-3 | (Rac)-SCH 563705 is the racemic mixture of SCH 563705. |
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V93201 | (S)-SCH 563705 | (S)-SCH 563705 is the S(+)-enantiomer of SCH 563705. | |
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V51648 | (±)-AMG-487 | 947536-03-0 | racemate of AMG-487; CXCR3 inhibitor |
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V26716 | MSX-127 (NSC-23026) | 6616-56-4 | MSX-127 is a CXCR4 antagonist. |
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V3792 | Navarixin | 473727-83-2 | Navarixin (formerly known as MK-7123; SCH527123; PS291822) is a novel potent and specific allosteric antagonist of CXCR1 and CXCR2 with antitumor and anti-inflammatory activity and is able to sensitize cells to oxaliplatin in preclinical colon cancer models. |
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V51677 | Ac-Pro-Gly-Pro-OH | 292171-04-1 | Ac-Pro-Gly-Pro-OH is an endogenous hydrolyzate of extracellular collagen and works as a CXCR2 agonist. |
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V51673 | ACT-672125 | 1449367-94-5 | ACT-672125 is a potent CXCR3 antagonist (inhibitor) with IC50 of 239 nM in human blood. |
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V51649 | ACT-777991 | 1967811-46-6 | ACT-777991 is a selective CXCR3 antagonist. |
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V86535 | ALX 40-4C Trifluoroacetate | ALX 40-4C Trifluoroacetate is a chemokine receptor (CXCR4) inhibitor that can inhibit the binding of SDF-1 to CXCR4 with a Ki value of 1 μM and has anti-HIV-1 effects. | |
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V3827 | AMD 3465 | 185991-24-6 | AMD3465 (AMD-3465) is a novel monomacrocyclic antagonist of CXCR4 with potential anticancer and anti-HIV activity. |
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V2749 | AMD 3465 hexahydrobromide | 185991-07-5 | AMD3465 hexahydrobromide (AMD-3465; GENZ-644494 6-HBr) is a novel monomacrocyclic antagonist of CXCR4 that has potential anticancer and anti-HIV activity. |
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V2055 | AMG 487 | 473719-41-4 | AMG-487 (AMG487) is a novel, potent, selective and oral antagonist of chemokine receptor 3CXCR3 with potential immunomodulatory and antiinflammatory activities. |
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V51671 | Antileukinate | 138559-60-1 | Antilebumin is a hexapeptide that is a potent activator of the CXC chemokine receptor (CXCR). |
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V2585 | ATI-2341 | 1337878-62-2 | ATI-2341 (ATI2341), a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is a novel and selective allosteric agonist of CXCR4 with anti-inflammatory and anticancer activity. |
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V77233 | ATI-2341 TFA | ATI-2341 is a potent, functionally selective allosteric agonist of CXC chemokine receptor type 4 (CXCR4) that works as a biasing ligand, favoring Gα1 activation over Gα13. | |
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V3257 | AZD5069 | 878385-84-3 | AZD-5069 (AZD5069) is a novel and potent CXCR2 chemokine receptor antagonist with potential anticancer and antiinflammatory activities. |
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V3799 | AZD8797 | 911715-90-7 | AZD8797 (AZD-8797) is a novel, selective, orally bioavailable and allosteric non-competitive modulator of the human CX3CR1 receptor with potential anti-Inflammatory and immunomodulatory activity. |
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V78682 | CCR7 antagonist 1 | CCR7 antagonist 1 (30c) is a dual antagonist of CXCR2 (IC50 = 11.02 μM) and CCR7 (IC50 = 0.43 μM). |