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CXCR

CXCR

CXCRs (CXC chemokine receptors) are membrane-integral proteins that bind and react to particular members of the CXC chemokine family of cytokines. They belong to a large family of G protein-linked receptors known as seven transmembrane (7-TM) proteins because they span the cell membrane seven times. They are one subfamily of chemokine receptors. CXCR1 through CXCR7 are the seven CXC chemokine receptors that are currently recognized in mammals.The CXC chemokine receptors CXCR1 and CXCR2 recognize CXC chemokines that have an E-L-R amino acid motif right next to their CXC motif. The majority of CXCR3-expressing cells are T lymphocytes. Like CCR5, CXCR4 is the receptor for a chemokine called CXCL12 (also known as SDF-1), and it is used by HIV-1 to enter target cells.The B cell-specific chemokine receptor CXCR5 plays a role in lymphocyte homing and the maturation of healthy lymphoid tissue. Prior to being given the name CXCR6, CXCR6 was known by three different names (STRL33, BONZO, and TYMSTR) because of its chromosomal location and similarity to other chemokine receptors in its gene sequence. CXCR7 was previously known as RDC-1 (an orphan receptor), but after it was discovered that CXCL12 (the ligand for CXCR4) causes chemotaxis in T lymphocytes, this molecule was renamed to CXCR7.

CXCR related products

Structure Cat No. Product Name CAS No. Product Description
(R,R)-CXCR2-IN-2 V51664 (R,R)-CXCR2-IN-2 1838123-22-0 CXCR2 antagonist
(±)-AMG-487 V51648 (±)-AMG-487 947536-03-0 racemate of AMG-487; CXCR3 inhibitor
2,5-双(吗啉代甲基)-对苯二酚 V26716 MSX-127 (NSC-23026) 6616-56-4 MSX-127 is a CXCR4 antagonist.
3-[[3-[(二甲基氨基)羰基]-2-羟基苯基]氨基]-4-[[(R)-1-(5-甲基呋喃-2-基)丙基]氨基]-3-环丁烯-1,2-二酮 V3792 Navarixin 473727-83-2 Navarixin (formerly known as MK-7123; SCH527123; PS291822) is a novel potent and specific allosteric antagonist of CXCR1 and CXCR2 with antitumor and anti-inflammatory activity and is able to sensitize cells to oxaliplatin in preclinical colon cancer models.
Ac-Pro-Gly-Pro-OH V51677 Ac-Pro-Gly-Pro-OH 292171-04-1 Ac-Pro-Gly-Pro-OH is an endogenous hydrolyzate of extracellular collagen and works as a CXCR2 agonist.
ACT-672125 V51673 ACT-672125 1449367-94-5 ACT-672125 is a potent CXCR3 antagonist (inhibitor) with IC50 of 239 nM in human blood.
ACT-777991 V51649 ACT-777991 1967811-46-6 ACT-777991 is a selective CXCR3 antagonist.
ALX 40-4C Trifluoroacetate V86535 ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate is a chemokine receptor (CXCR4) inhibitor that can inhibit the binding of SDF-1 to CXCR4 with a Ki value of 1 μM and has anti-HIV-1 effects.
AMD 3465 V3827 AMD 3465 185991-24-6 AMD3465 (AMD-3465) is a novel monomacrocyclic antagonist of CXCR4 with potential anticancer and anti-HIV activity.
AMD 3465 hexahydrobromide V2749 AMD 3465 hexahydrobromide 185991-07-5 AMD3465 hexahydrobromide (AMD-3465; GENZ-644494 6-HBr) is a novel monomacrocyclic antagonist of CXCR4 that has potential anticancer and anti-HIV activity.
AMG 487 V2055 AMG 487 473719-41-4 AMG-487 (AMG487) is a novel, potent, selective and oral antagonist of chemokine receptor 3CXCR3 with potential immunomodulatory and antiinflammatory activities.
Antileukinate V51671 Antileukinate 138559-60-1 Antilebumin is a hexapeptide that is a potent activator of the CXC chemokine receptor (CXCR).
ATI-2341 V2585 ATI-2341 1337878-62-2 ATI-2341 (ATI2341), a pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is a novel and selective allosteric agonist of CXCR4 with anti-inflammatory and anticancer activity.
ATI-2341 TFA V77233 ATI-2341 TFA ATI-2341 is a potent, functionally selective allosteric agonist of CXC chemokine receptor type 4 (CXCR4) that works as a biasing ligand, favoring Gα1 activation over Gα13.
AZD5069 V3257 AZD5069 878385-84-3 AZD-5069 (AZD5069) is a novel and potent CXCR2 chemokine receptor antagonist with potential anticancer and antiinflammatory activities.
AZD8797 V3799 AZD8797 911715-90-7 AZD8797 (AZD-8797) is a novel, selective, orally bioavailable and allosteric non-competitive modulator of the human CX3CR1 receptor with potential anti-Inflammatory and immunomodulatory activity.
CCR7 antagonist 1 V78682 CCR7 antagonist 1 CCR7 antagonist 1 (30c) is a dual antagonist of CXCR2 (IC50 = 11.02 μM) and CCR7 (IC50 = 0.43 μM).
Corydalmine (L-Corydalmine; TLZ-16) V53953 Corydalmine (L-Corydalmine; TLZ-16) 30413-84-4 Corydalmine (L-Corydalmine) inhibits spore germination of certain plant pathogens and saprophytic fungi. Corydalmine is orally active and has been studied for pain relief.
CTCE-0214 V51676 CTCE-0214 577782-52-6 CTCE-0214 is a CXCR4 (chemokine CXC receptor 4) agonist and SDF-1α peptide analog.
CTCE-9908 V51125 CTCE-9908 1030384-98-5 CXCR4 antagonist
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