The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.
Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2738 | (1S,3R,5R)-PIM447 dihydrochloride | 1S,3R,5R)-PIM447 dihydrochloride a potentPIMinhibitor extracted withIC50values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. | |
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V4239 | AZD1208 hydrochloride | 1621866-96-3 | AZD1208 hydrochloride is a novel, potent, highly selective and orally bioavailable small molecule pan-inhibitor of Pim kinase with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. |
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V33131 | CX-6258 hydrochloride hydrate | 1353858-99-7 | CX-6258 HCl hydrate is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
|
V74379 | FD1024 | 1422456-47-0 | FD1024 is a PIM inhibitor (IC50s for PIM1, 2, and 3 are 1.96, 38.9, and 4.17 nM). |
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V67542 | GSK-3β inhibitor 13 | 2227316-74-5 | GSK-3β inhibitor 13 (compound 47) is an orally bioactive and potent GSK-3β inhibitor (antagonist) with blood-brain permeability. |
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V22194 | Hispidulin | 1447-88-7 | Hispidulin is a naturally occurring flavonoid with a wide range of bioactivities. |
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V69221 | IBL-302 (AMU302) | 1414455-21-2 | IBL-302 (AMU302) is an orally bioavailable dual-signal inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. |
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V4089 | INCB053914 | 1620012-39-6 | INCB053914 is a novel, potent, selective, and ATP-competitive small molecule pan-inhibitor ofPIM (Proviral Integration site of Moloney murine leukemia virus) kinaseswith IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. |
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V4088 | INCB053914 phosphate | 2088852-47-3 | INCB053914 is a novel, potent, selective, and ATP-competitive small molecule pan-inhibitor ofPIM (Proviral Integration site of Moloney murine leukemia virus) kinaseswith IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. |
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V74391 | MNK/PIM-IN-1 | 2430792-91-7 | MNK/PIM-IN-1 is a novel MNK/PIM dual (bifunctional) inhibitor (antagonist) with good pharmacokinetic characteristics. |
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V2370 | NSC 31205 | 6320-51-0 | Pim-1/2 kinase inhibitor 1 is an orally bioavailable Pim-1/2 kinase inhibitor. |
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V74380 | Pim-1 kinase inhibitor 2 | 2543624-91-3 | Pim-1 kinase inhibitor 2 (Compound 13) is a potent Pim-1 kinase inhibitor. |
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V74390 | Pim-1 kinase inhibitor 3 | 2801695-39-4 | Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor (antagonist) with IC50 of 35.13 nM. |
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V81141 | Pim-1 kinase inhibitor 4 | Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC50= 17.01 nM). | |
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V74386 | Pim-1 kinase inhibitor 5 | 2928606-67-9 | Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC50= 0.61 μM). |
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V74383 | Pim-1 kinase inhibitor 6 | 2928606-69-1 | Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor (antagonist) with IC50 of 0.46 μM and significant cytotoxic effect against cancer cells. |
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V74388 | PIM-1/HDAC-IN-1 | 2897622-19-2 | PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor (antagonist) with IC50 of 343.87 nM. |
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V74384 | PIM-IN-1 | 2698319-19-4 | PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC50 = 61 nM; pS6, EC50 = 71 nM). |
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V74385 | PIM-IN-2 | 1006699-45-1 | PIM-IN-2 is a Pim kinase inhibitor (IC50 = 25 nM). |
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V74381 | PIM1-IN-2 | 477845-12-8 | PIM1-IN-2 is a potent ATP-competitive Pim-1 inhibitor (antagonist) with a Ki of 91 nm. |
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