Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin. The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V0294 | 2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2) | 362-07-2 | 2-Methoxyestradiol (2-MeOE2, NSC-659853, 2-ME2; 2-ME), an endogenous/natural metabolite ofestradiol [17β-estradiol (E2)], is a potent inhibitor of tubulin with potential anticancer activity. |
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V1607 | ABT-751 (E 7010) | 141430-65-1 | ABT-751 (also known as ABT751;E-7010;E7010) is a novel, potent,sulfonamide-basedand orally bioavailable antimitotic/antitubulinagent or tubulin inhibitor/microtubule destablizer with potential antitumor activity. |
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V1620 | Albendazole (SKF-62979) | 54965-21-8 | Albendazole (formerly SKF-62979; SKF62979; SKF 62979;Zentel;Albenza;Eskazole; Valbazen), a benzimidazole analog and tubulin inhibitor, is an orally bioavailable anti-parasitic drug that has been approved for use in the treatment of various worm infestations such as giardiasis, neurocysticercosis, filariasis,hydatid disease,trichuriasis, pinworm disease, and ascariasis, among others. |
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V1609 | Cabazitaxel (XRP-6258; RPR-116258A; taxoid XRP6258) | 183133-96-2 | Cabazitaxel (formerly known as RPR-116258A, XRP-6258, TXD-258; Jevtana) is a semi-synthetic and marketed taxane analog (the natural taxoid 10-deacetylbaccatin III) with potential anticancer activity and improved pharmacological profiles (e. |
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V1616 | CK-636 (CK-0944636) | 442632-72-6 | CK-636 (also called CK636;CK-0944636;CK0944636)is a potent inhibitor of the actin-related protein(Arp2/3) complex with IC50 values of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. |
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V1610 | Combretastatin A4 (CA-4; CRC 87-09) | 117048-59-6 | Combretastatin A4 (CA-4; CRC-87-09; Combretastatin A-4) is a highly potent tubulin/microtubuleinhibitor or microtubule polymerization destablizer with potential antitumor activity. |
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V1618 | CW069 | 1594094-64-0 | CW069 (CW-069; CW 069) is a potent, selective and allosteric inhibitor of microtubule motor protein HSET with potential antitumor activity. |
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V1604 | Docetaxel (RP 56976) | 114977-28-5 | Docetaxel (formerly known as RP56976;NSC628503; RP-56976;NSC-628503;Taxotere), a semisynthetic analog ofpaclitaxel and approved anticancer drug, is a mitotic inhibitor and tubulin inhibitor that inhibits the depolymerization of microtubules by binding to and stabilizing microtubules. |
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V1611 | Docetaxel Trihydrate (RP 56976) | 148408-66-6 | DocetaxelTrihydrate (formerly RP-56976; NSC-628503; trade name Taxotere), the trihydrated form of docetaxel which is a paclitaxel analog, is a tubulin/mitotic inhibitor with a broad spectrum of antineoplastic activities. |
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V1619 | Epothilone A (Epo A) | 152044-53-6 | Epothilone A (also abbreviated as Epo A), similar to paclitaxel in terms of mechanism of action, is also a naturally occurring microtubule-stabilizing macrolide agent (also called mitotic inhibitor or tubulin inhibitor) isolated from the myxobacteriumSorangium cellulosum with potential antineoplastic activity. |
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V1606 | Epothilone B (EPO 906; Patupilone) | 152044-54-7 | Epothilone B (formerly known as EO-906;patupilone;EPO 906A; EPO906, Patupilone) is a paclitaxel-class of microtubule-stabilizing agent (also called mitotic inhibitor or tubulin inhibitor) with potential antitumor activity and has been approved for cancer treatment. |
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V4824 | Eribulin mesylate | 441045-17-6 | Eribulin mesylate (E7389 mesylate) is the mesylate salt ofEribulin(E-7389; Halaven;B1939; ER-086526;Eisai), which asynthetic analogue of the marine-originatednaturalproduct halichondrin B, is an antitubulin/microtubule targeting agent (MTA)/mitotic/tubulin inhibitor approved for use in the treatment of metastatic breast cancer. |
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V1617 | Fosbretabulin disodium (CA 4DP) | 168555-66-6 | Combretastatin A4 Phosphate Disodium (also called CA4P, Fosbretabulin; CA 4DP; CA-4P; Zybrestat) is the water-soluble prodrug that has to be activated to the active form, Combretastatin A4 (CA4), which is a highly potent MTA (microtubule-targeting agent) or tubulin inhibitor that acts as a potent anticancer agent that binds β-tubulin with a Kd of 0.4 μM in a cell-free assay. |
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V1623 | Griseofulvin (Grifulvin) | 126-07-8 | Griseofulvin (Gris-PEG; Grifulvin; Fulvicin, Grisactin, Amudane), a naturally occurring spirocyclic compound isolatedfrom some strains of the mold Penicillium griseofulvumam, is an oral antifungal medication approved for use in the treatment of various dermatophytoses (ringworm) such as fungal infections of the nails and skin when antifungal creams did not work. |
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V1614 | INH1 (IBT13131) | 313553-47-8 | INH1 (also calledIBT-13131;INH-1; IBT13131) is a potent and cell-permeable Hec1 (High expression in cancer 1) inhibitor with potential anticancer activity. |
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V1613 | INH6 | 1001753-24-7 | INH6 (INH-6; INH 6) is a novel, potent and cell-permeable inhibitor of High expression in cancer 1 (Hec1) with potential anticancer activity. |
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V1622 | Lexibulin (CYT-997) | 917111-44-5 | CYT997 (also called Lexibulin; CYT-997; CYT 997) is a potent VDA-vascular disrupting agent and also apotent microtubule polymerization/mitotic inhibitor with potential anticancer activity. |
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V1608 | Nocodazole (Oncodazole; R17934) | 31430-18-9 | Nocodazole (Oncodazole; R-17934;R17934) is a potent and rapidly-reversible inhibitor of microtubule polymerization/microtubule destablizer, the so called antimitotic or antitubulin agent, with potential antineoplastic activity. |
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V1603 | Paclitaxel (Taxol) | 33069-62-4 | Paclitaxel (also known as NSC-125973; BMS-181339-01;trade name taxol; Anzatax; Asotax; Bristaxol)is a highly potent microtubule polymer stabilizer (mitotic inhibitor that stabilizes the polymerization of tubulin) with an IC50 of 0.1 pM in human endothelial cells. |
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V3031 | SMART | 1135797-91-9 | SMART is a highly potent tubulin inhibitor with IC50 in the nanomolar range (20-30 nM) in a number various cancer cell lines including prostate cancer and melanoma cells. |
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