S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).
Nitric oxide (NO) adduct S-nitrosoglutathione (GSNO), a crucial reservoir for NO bioactivity, is reduced by GSNOR. It has been discovered that GSNOR plays a key role in plant resistance to bacterial and fungal pathogens. The expression of GSNOR is widespread, and it catalyzes the denitrosylation of GSNO, which reduces protein S-nitrosylation in beta-cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V136980 | GSNOR-IN-1 | GSNOR-IN-1 is a prodrug of GSNOR-IN-2, which is an S-nitrosoglutathione reductase (GSNOR) inhibitor that can cross the blood-brain barrier. | |
|
V136981 | GSNOR-IN-2 | GSNOR-IN-2 is an inhibitor of S-nitrosoglutathione reductase (GSNOR) with an IC50 of 44.12 nM. | |
|
V1914 | N6022 | 1208315-24-5 | N6022 is a selective, first-in-class and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) with IC50 of 8 nM and Ki of 2.5 nM. |
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