One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70196 | (E)-Akt inhibitor-IV ((E)-AKTIV) | 959841-49-7 | (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor (antagonist) with significant cell toxicity/cytotoxicity. |
|
V70199 | (−)-Myrtenal ((1R)-(-)-Myrtenal; (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal) | 18486-69-6 | (−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally bioavailable terpene with anticancer effect. |
|
V70211 | 22-(4′-py)-JA (22-(4′-Pyridinecarbonyl) jorunnamycin A) | 1178895-15-2 | 22-(4′-py)-JA is a semi-synthetic analogue of kunamycin A (JA), which can be extracted from Xestospongia sp. |
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V51368 | 24-Methylene cycloartanyl ferulate | 469-36-3 | Akt1 inhibitor |
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V90822 | 5,4'-Dihydroxy-6,8-dimethoxy-7-O-rhamnosyl flavone | 927406-46-0 | 5,4'-Dihydroxy-6,8-dimethoxy-7-O-rhamnosyl flavone (DDR) is an anticancer agent that can be extracted from Indigofera oleifera. |
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V0164 | A-674563 | 552325-73-2 | A-674563 is a novel and potent Akt1 inhibitor with potential anticancer activity. |
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V2482 | A-674563 hydrochloride | 2070009-66-2 | A-674563 HCl is a selective and effective Akt1 inhibitor (antagonist) with Ki of 11 nM. |
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V69649 | Ack1 inhibitor 1 | 2924415-92-7 | Ack1 inhibitor 1 is a specific, orally bioactive ACK1 kinase inhibitor (antagonist) with IC50 of 2.1 nM. |
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V70201 | Adropin (34-76) (human, mouse, rat) | 1802086-30-1 | Adropin (34-76) (human, mouse, rat) modulates fuel selection preference in skeletal muscle. |
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V77276 | AKT Kinase Inhibitor hydrochloride | 3026697-00-4 | AKT Kinase Inhibitor HCl is an Akt inhibitor (antagonist) with anti-tumor activity. |
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V77875 | AKT-IN-11 | AKT-IN-11 is one of the most effective anti-bacterial agents against human liver cancer Bel-7402 cell line, with IC501.15μM. | |
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V70213 | AKT-IN-14 | 2781918-35-0 | AKT-IN-14 (Example 2) is a potent AKT inhibitor (antagonist) with IC50s of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2 and AKT3 respectively. |
|
V70205 | AKT-IN-14 free base | 2781918-27-0 | AKT-IN-14 (Example 2) free base is a potent AKT inhibitor (antagonist) with IC50s of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2 and AKT3 respectively. |
|
V79783 | AKT-IN-17 | AKT-IN-17 is an orally bioavailable AKt inhibitor. | |
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V79968 | AKT-IN-18 | AKT-IN-18 is an Akt inhibitor that can suppress Akt in A549 cells with IC50 of 69.45 μM. | |
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V84674 | AKT-IN-21 | ||
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V84397 | AKT-IN-22 | 1313880-28-2 | |
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V70221 | AKT-IN-5 | 1402608-05-2 | AKT-IN-5 (Example 8) is an Akt inhibitor (antagonist) with IC50s of 450 nM and 400 nM for Akt1 and Akt2, respectively. |
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V70217 | AKT-IN-6 | 1430056-54-4 | AKT-IN-6 (Example 13) is a potent AKT inhibitor. |
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V79701 | Akt/ROCK-IN-1 | 2983889-44-5 | Akt/ROCK-IN-1 (B12) is a dual (bifunctional) inhibitor of Akt and ROCK with IC50 of 0.023 nM and 1.47 nM, respectively. |
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