c-Kit

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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c-Kit

c-Kit (Mast/stem cell growth factor receptor, SCFR or CD117) is a proteinthat in humans is encoded by the KIT gene.An essential cell surface marker for identifying specific kinds of hematopoietic (blood) progenitors in the bone marrow is called c-Kit (CD117). In addition to other cell types, hematopoietic stem cells express the cytokine receptor c-Kit on their surface. Some types of cancer may be linked to altered forms of this receptor. Stem cell factor is bound by the type III receptor tyrosine kinase known as c-Kit. To activate its intrinsic tyrosine kinase activity, c-Kit forms an adimer with stem cell factor (SCF). This adimer then phosphorylates and activates signal transduction molecules that spread the signal throughout the cell. Cell survival, division, and proliferation are affected by c-Kit signaling.

c-Kit related products

Cat No.	Product Name	CAS No.	Product Description
V109189	(S)-c-Kit-IN-12	2797973-69-2	(S)-c-Kit-IN-12 (compound 2b) is a potent c-Kit inhibitor with IC50 values of less than 10 nM against c-Kit in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, and EX11 DEL/V654A).
V77254	Anti-Mouse CD117 Antibody		Anti-Mouse CD117 Antibody is an IgG2b antibody inhibitor against mouse CD117.
V3474	AZD3229	2248003-60-1	AZD3229 (AZD-3229) is a novel, potent, pan-KIT mutantinhibitor with anticancer activity.
V4154	AZD3229 Tosylate	2248003-71-4	AZD3229 Tosylate, the tosylate salt ofAZD-3229,is a novel, potent, pan-KIT mutantinhibitor with antitumor activity.
V69291	Bezuclastinib (CGT9486; PLX 9486)	1616385-51-3	Bezuclastinib (CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V, 0.0001
V120316	c-Kit Receptor modulator-1	932401-20-2	c-Kit receptor modulator-1 (compound #22) is a c-Kit receptor modulator.
V22674	ISCK03	945526-43-2	ISCK03 is a potent c-kit inhibitor.
V120281	c-Kit-IN-10	1123512-36-6	c-Kit-IN-10 (compound 1) is a c-Kit inhibitor.
V120201	c-Kit-IN-11	1185279-55-3	c-Kit-IN-11 (compound A7) is a c-Kit inhibitor with an IC50 value of 76 nM against Mo7e cells.
V109236	c-Kit-IN-12	2797973-68-1	c-Kit-IN-12 (compound 2a) is a potent c-Kit inhibitor with IC50 values of less than 10 nM against c-Kit in four KIT mutant cell models (BAF3 KIT EX11 DEL, EX11 DEL/D816H, EX11 DEL/T670I, and EX11 DEL/V654A).
V109369	c-Kit-IN-13	3041025-10-6	c-Kit-IN-13 (compound I) is a c-kit kinase inhibitor.
V110544	c-Kit-IN-14	3041025-49-1	c-Kit-IN-14 (compound 1) is a c-kit kinase inhibitor.
V93685	c-Kit-IN-6		c-Kit-IN-6 (Compound 101) is a c-Kit inhibitor with IC50 values ranging from 100 nM to 1 μM.
V93129	c-Kit-IN-8	2941024-89-9	c-Kit-IN-8 (Compound 53) is an inhibitor of c-Kit kinase and inhibits uKIT kinase with IC50 > 1 μM.
V116395	CD117/c-Kit aptamer sodium		CD117/c-Kit sodium aptamer is a single-stranded DNA aptamer that targets CD117, a biomarker highly expressed in acute myeloid leukemia (AML) cells.
V116175	CHMFL-KIT-031		CHMFL-KIT-031 is a highly selective KIT V559D inhibitor with an IC50 value of 28 nM.
V3757	DCC-2618 HCl		Ripretinib HCl (DCC2618; DCC-2618; Qinlock), the hydrochloride salt of DCC-2618, is an orally bioactive pan KIT and PDGFRA inhibitor approved in 2020 for the treatment of adults with advanced gastrointestinal stromal tumor.
V69295	Elenestinib (BLU-263)	2505078-08-8	Elenestinib (BLU-263) is a potent orally bioactive tyrosine kinase inhibitor.
V69296	Elenestinib phosphate (BLU-263 phosphate)	2832013-93-9	Elenestinib phosphate (BLU-263 phosphate) is a potent orally bioactive tyrosine kinase inhibitor.
V118789	KIT A829P Recombinant Human Active Protein Kinase		KIT (CD117) is an important cell surface marker used to identify certain types of hematopoietic progenitor cells in the bone marrow.