PIKfyve

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

+MORE

PIKfyve

The PIKFYVE gene in humans codes for the enzyme PIKfyve, a phosphoinositide kinase that contains the FYVE finger. PIKfyve's primary enzyme activity is the phosphorylation of PtdIns3P to PtdIns(3,5)P2. Both PtdIns(3,5)P2 and phosphatidylinositol 5-phosphate (PtdIns5P) are produced by PIKfyve activity. The large protein PIKfyve is expressed in various spliced forms and has several functional domains.The FYVE finger domain of PIKfyve is crucial for localizing the protein to the cytosolic leaflet of endosomes by directly interacting with membrane PtdIns(3)P. Endosome enlargement and cytoplasmic vacuolation are brought on by decreased PtdIns(3,5)P2 synthesis, which is impaired by dominant-interfering mutants, siRNA-mediated ablation, or pharmacological inhibition of the PIKfyve enzyme. As a result, PIKfyve participates in various endosome dynamics through the production of PtdIns(3,5)P2, which has an impact on a number of trafficking pathways that originate from or pass through the endosomal system on their way to the trans-Golgi network or later compartments along the endocytic pathway.

PIKfyve related products

Cat No.	Product Name	CAS No.	Product Description
V1558	APY0201	1232221-74-7	APY0201 (APY-0201; APY 0201) is a novel, potent and selectivePIKfyve inhibitor with potential anti-inflammatory activity.
V117646	AS2677131	2171502-44-4	AS2677131 is a potent, orally active PIKfyve inhibitor.
V120174	AS2795440	2171506-45-7	AS2795440 is a PIKfyve inhibitor.
V69245	PIKfyve-IN-1	2857982-26-2	PIKfyve-IN-1 is a potent and cell-active chemical probe that can inhibit phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) with IC50 of 6.9 nM.
V69243	PIKfyve-IN-2	2245319-25-7	PIKfyve-IN-2 is a potent PIKfyve kinase inhibitor that may be utilized in cancer and autoimmune disease study.
V118611	TMX-4140	2867519-51-3	TMX-4140 is a selective PIP4K2C inhibitor with a KD value of 7.2 nM for PIP4K2C, which is superior to its inhibitory activity against PIP4K2B.
V99637	WX8	232935-92-1	WX8 (Ro 91-4714) is an ATP-competitive PIKFYVE inhibitor with Kd values of 0.9 nM and 340 nM for PIKFYVE and PIP4K2C, respectively.