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P-gp

P-gp

The crucial cell membrane protein known as P-glycoprotein (P-gp), also referred to as multidrug resistance protein 1 (MDR1), is responsible for expelling a variety of foreign substances. It is an ATP-dependent efflux pump with a broad substrate specificity, to put it more precisely. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood-brain barrier and blood-testis barrier, where it pumps them back into the capillaries.Additionally, some cancer cells overexpress P-gp, making these cancers multi-drug resistant. P-gp is a broad substrate specificity ATP-dependent drug efflux pump for xenobiotic compounds. It controls the reduced drug accumulation in cells with multiple drug resistance and frequently controls the emergence of anticancer drug resistance. The blood-brain barrier uses this protein as a transporter as well.

P-gp related products

Structure Cat No. Product Name CAS No. Product Description
(S)-Tenacissoside F V114270 (S)-Tenacissoside F 928151-78-4 (S)-Tenacissoside F (compound P20) is a polyoxypregnane compound found in Marsdenia tenacissima.
1-[4-[2-羟基-3-(5-喹啉基氧基)丙基]-1-哌嗪基]-2,2-二苯基乙酮 V20174 Ethanone,1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl- 129716-58-1 Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound.
11α-O-Benzoyl-12β-O-acetyltenacigenin B V97493 11α-O-Benzoyl-12β-O-acetyltenacigenin B 154022-52-3 11α-O-benzoyl-12β-O-acetyl tenacigenin B is a P-glycoprotein (Pgp) inhibitor derived from Marsdenia tenacissima and is a derivative of Tenacigenin B.
8-Prenylchrysin V102508 8-Prenylchrysin 34125-75-2 8-Prenylchrysin is a C8-prenyl flavonoid.
ABCB1-IN-1 V77720 ABCB1-IN-1 2986412-70-6 ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1.
ABCB1-IN-2 V98194 ABCB1-IN-2 ABCB1-IN-2 (compound 16q) is a functional inhibitor that can directly bind to the ABCB1 protein and stabilize its structure without affecting the expression and subcellular localization of ABCB1.
ABCB1/ABCG2-IN-1 V128035 ABCB1/ABCG2-IN-1 ABCB1/ABCG2-IN-1 is an inhibitor of ABCB1 and ABCB2 transporters.
Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) V106375 Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) is a murine IgG2a, kappa antibody inhibitor directed against monkey or human MDR-1/CD243.
Anticancer agent 108 V79976 Anticancer agent 108 Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor (antagonist) with anti-tumor activity and low toxicity to normal and pseudonormal cells.
Anticancer agent 191 V87124 Anticancer agent 191 Anticancer agent 191 (Compound 2) is a probenecid derivative.
Antitrypanosomal agent 24 V129168 Antitrypanosomal agent 24 Antitrypanosomal agent 24 is a benzothiazole amicoxime compound with potent and selective antitrypanosomal activity (IC50 = 0.92 μM).
Ardeemin V129374 Ardeemin 148441-25-2 Ardeemin ((-)-Ardeemin) binds to P-glycoprotein, preventing anticancer drugs from being pumped out of cells.
Boeravinone B V74216 Boeravinone B 114567-34-9 Boeravinone B is a dual (bifunctional) inhibitor of Staphylococcus aureus and human P-glycoprotein NorA bacterial efflux pumps, which can reduce bacterial biofilm formation and invasion.
c-Met-IN-23 V87204 c-Met-IN-23 c-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC50 for c-Met is 0.052 μM).
C2 Adamantanyl globotriaosylceramide (d18:1/2:0) V119353 C2 Adamantanyl globotriaosylceramide (d18:1/2:0) 261155-87-7 C2 adamantyl globular trihexosylceramide (d18:1/2:0) (AdaGb3) is a biologically active, water-soluble ceramide trihexosyl glycoside analog.
C3N-Dbn-Trp2 V87203 C3N-Dbn-Trp2 2631659-57-7 C3N-Dbn-Trp2 is an inhibitor of the ATP-binding cassette transporter ABCB1.
CJZ3 V104776 CJZ3 766508-73-0 CJZ3 is a reversible inhibitor of P-glycoprotein (P-gp), which can cause drug (Rh123) aggregation in cells and increase the permeability of the blood-brain barrier (BBB).
Clausarin V108528 Clausarin 62770-67-6 Krausarin is a selective P-glycoprotein (P-gp) inhibitor that inhibits P-gp-mediated drug efflux.
CPI1 V106301 CPI1 CPI1 is a potent and highly specific inhibitor of multidrug resistance protein 1 (MRP1).
DM-4103 V134003 DM-4103 1346599-56-1 DM-4103 is the major metabolite of tolvaptan, which is primarily metabolized in the liver by the enzyme CYP3A4.
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