The crucial cell membrane protein known as P-glycoprotein (P-gp), also referred to as multidrug resistance protein 1 (MDR1), is responsible for expelling a variety of foreign substances. It is an ATP-dependent efflux pump with a broad substrate specificity, to put it more precisely. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood-brain barrier and blood-testis barrier, where it pumps them back into the capillaries.Additionally, some cancer cells overexpress P-gp, making these cancers multi-drug resistant. P-gp is a broad substrate specificity ATP-dependent drug efflux pump for xenobiotic compounds. It controls the reduced drug accumulation in cells with multiple drug resistance and frequently controls the emergence of anticancer drug resistance. The blood-brain barrier uses this protein as a transporter as well.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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![1-[4-[2-羟基-3-(5-喹啉基氧基)丙基]-1-哌嗪基]-2,2-二苯基乙酮](http://www.invivochem.com/upload/0290/3dd64c0b-b713-460b-95b6-70a3ff1b8442.png)
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V20174 | Ethanone,1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl- | 129716-58-1 | Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound. |
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V97493 | 11α-O-Benzoyl-12β-O-acetyltenacigenin B | 154022-52-3 | 11α-O-benzoyl-12β-O-acetyl tenacigenin B is a P-glycoprotein (Pgp) inhibitor derived from Marsdenia tenacissima and is a derivative of Tenacigenin B. |
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V102508 | 8-Prenylchrysin | 34125-75-2 | |
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V77720 | ABCB1-IN-1 | 2986412-70-6 | ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1. |
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V98194 | ABCB1-IN-2 | ABCB1-IN-2 (compound 16q) is a functional inhibitor that can directly bind to the ABCB1 protein and stabilize its structure without affecting the expression and subcellular localization of ABCB1. | |
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V106375 | Anti-Monkey/Human MDR-1/CD243 Antibody (UIC2) | ||
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V79976 | Anticancer agent 108 | Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor (antagonist) with anti-tumor activity and low toxicity to normal and pseudonormal cells. | |
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V87124 | Anticancer agent 191 | Anticancer agent 191 (Compound 2) is a probenecid derivative. | |
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V74216 | Boeravinone B | 114567-34-9 | Boeravinone B is a dual (bifunctional) inhibitor of Staphylococcus aureus and human P-glycoprotein NorA bacterial efflux pumps, which can reduce bacterial biofilm formation and invasion. |
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V87204 | c-Met-IN-23 | c-Met-IN-23 (Compound 12g) is a c-Met inhibitor (IC50 for c-Met is 0.052 μM). | |
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V87203 | C3N-Dbn-Trp2 | 2631659-57-7 | C3N-Dbn-Trp2 is an inhibitor of the ATP-binding cassette transporter ABCB1. |
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V104776 | CJZ3 | 766508-73-0 | |
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V106301 | CPI1 | ||
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V20530 | Encequidar (HM-30181; HM-30181A) | 849675-66-7 | Encequidar (formerly HM-30181; HM30181; HM30181A) is a novel, potent, selective, and orally bioavailable inhibitor of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter P-gp (P-glycoprotein). |
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V93972 | Encequidar hydrochloride | 849675-88-3 | Encequidar hydrochloride (HM30181 hydrochloride) is an oral P-glycoprotein (P-gp) inhibitor with the activity of increasing the oral bioavailability of P-gp substrate drugs. |
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V74213 | Encequidar mesylate hydrochloride (HM30181 mesylate hydrochloride; HM30181A mesylate hydrochloride) | 2097125-58-9 | Encequidar (HM30181) mesylate HCl is a potent and specific inhibitor of P-glycoprotein (MDR1). |
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V22218 | Encequidar mesylate (HM-30181; HM-30181A) | 849675-87-2 | Encequidarmesylate (HM30181; HM-30181A; Oraxol), the mesylate salt of encequidar, is a novel,highly specific, andorally bioavailable inhibitor of P-glycoprotein (P-gp), which is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter. |
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V74221 | Epoxylathyrol | 28649-60-7 | Epoxylathyrol is an epoxyethoxy ether analogue extracted from Euphorbia boetica. |
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V74224 | Euphohelioscopin A | 87064-61-7 | Euphohelioscopin A is a diterpenoid that can be extracted from the Euphorbia helioscopia L.plant. |
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V74222 | FM04 | 1807320-40-6 | FM04 is a potent inhibitor of P-glycoprotein (P-gp) (EC50=83 nM). |
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