Steroid 5-reductase (5AR) is a membrane-bound protein that converts steroid hormones like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstenedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.
The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87261 | 8,11-Eicosadiynoic acid | 82073-91-4 | 8,11-Eicosadiynoic acid is an unsaturated fatty acid and a steroid 5α-reductase inhibitor. |
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V132501 | Cryptolepinone | 178884-07-6 | Cryptolepinone is a quinone reductase activator with a CD value (doubling induction concentration) of 0.02 μg/mL, found in Sida acuta. |
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V115030 | Eucalbanin B | 95263-69-7 | Cornusin A is a dimeric ellagic tannin. |
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V116282 | MK-0963 | 103497-68-3 | MK-0963 is a steroid 5α-reductase inhibitor. |
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V141615 | NQO1 inducer 1 | NQO1 inducer 1 is a potent NQO1 inducer (CD=3 μM). | |
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V141650 | NSC 645827 | 128113-19-9 | NSC 645827 is an inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1) with an IC50 of 0.7 μM. |
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V143504 | Pterulinic acid | 190143-30-7 | Pterulinic acid is a coenzyme I:coenzyme Q oxidoreductase inhibitor. |
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V143505 | Pterulone | 190143-31-8 | Pterulone is a coenzyme I:coenzyme Q oxidoreductase inhibitor found in the fungus Pterula SP.82168. |
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V118756 | SRD5A1-IN-2 | SRD5A1-IN-2 is a steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 value of 8.5 μM. | |
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V87262 | Turosteride | 137099-09-3 | Turosteride is a selective 5 alpha-reductase inhibitor with IC50 values of 55 and 53 nM for human and rat prostate 5 alpha-reductase, respectively. |
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V1808 | Dutasteride (GG 745; GI 198745) | 164656-23-9 | Dutasteride (also known as GI198745, GG-745; trade names: Avodart, Avidart) is a potent dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). |
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V1809 | Finasteride (MK-906) | 98319-26-7 | Finasteride (also known as MK-906)is a potent, reversible, and orally bioactive inhibitor of the rat typeII 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). |
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