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5-alpha Reductase

5-alpha Reductase

Steroid 5-reductase (5AR) is a membrane-bound protein that converts steroid hormones like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstenedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.

The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases.

5-alpha Reductase related products

Structure Cat No. Product Name CAS No. Product Description
8,11-Eicosadiynoic acid V87261 8,11-Eicosadiynoic acid 82073-91-4 8,11-Eicosadiynoic acid is an unsaturated fatty acid and a steroid 5α-reductase inhibitor.
Turosteride V87262 Turosteride 137099-09-3 Turosteride is a selective 5 alpha-reductase inhibitor with IC50 values of 55 and 53 nM for human and rat prostate 5 alpha-reductase, respectively.
度他雄胺 V1808 Dutasteride (GG 745; GI 198745) 164656-23-9 Dutasteride (also known as GI198745, GG-745; trade names: Avodart, Avidart) is a potent dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
非那雄胺 V1809 Finasteride (MK-906) 98319-26-7 Finasteride (also known as MK-906)is a potent, reversible, and orally bioactive inhibitor of the rat typeII 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).
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