The serine hydrolase family of enzymes includes the membrane-bound protein FAAH (Fatty Acid Amide Hydrolase).Numerous significant endogenous fatty acid amides, such as the putative anti-inflammatory compound palmitoylethanolamide (PEA) and the endogenous cannabimimetic anandamide (AEA), which induces sleep, are hydrolyzed by FAAH. A class of bioactive lipids known as fatty acid amides (FAAs) signaling is terminated by FAAH both in peripheral tissues and the central nervous system (CNS).
FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V87419 | 3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone | 875014-22-5 | 3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone (compound 45) is a potent fatty acid amide hydrolase (FAAH) inhibitor (pI50: 5.89) and lacks affinity for CB(1) and CB(2) cannabinoid receptors. |
|
V87420 | AKU-005 | 1515855-85-2 | AKU-005 is a dual inhibitor of FAAH and MAGL with IC50 values of 63 and 389 nM for rat and human FAAH, respectively. |
|
V71790 | AM 374 | 86855-26-7 | AM 374 is a fatty acid amide hydrolase (FAAH) inhibitor. |
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V87424 | Arachidonamide | 85146-53-8 | Arachidonamide is a substrate for fatty amide hydrolases. |
|
V4091 | BIA10-2474 | 1233855-46-3 | BIA 10-2474 is a novel, potent,long-acting and reversible inhibitor offatty acid amide hydrolase (FAAH)withIC50values of 50 to 70mg/kg in various rat brain regions. |
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V84343 | CAY10435 | 288862-73-7 | |
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V71593 | CB2R/FAAH modulator-1 | 928892-60-8 | CB2R/FAAH modulator-1 is a full cannabinoid type 2 receptor (CB2R) agonist/activator with Ki of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. |
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V71589 | CB2R/FAAH modulator-2 | 2876918-68-0 | CB2R/FAAH modulator-2 (compound 26) is a dual-targeting modulator that works as a CB2R agonist and FAAH inhibitor. |
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V71600 | CB2R/FAAH modulator-3 | 2876918-67-9 | CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that works as a CB2R agonist and FAAH inhibitor. |
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V87422 | FAAH inhibitor 2 | 1450603-63-0 | FAAH inhibitor 2 (Compound 17b) is an irreversible fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 0.153 μM. |
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V3293 | FAAH-IN-2 | 184475-71-6 | FAAH-IN-2 is a novel and potent FAAH (fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. |
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V78760 | FAAH-IN-7 | FAAH-IN-7 is a reversible and potent inhibitor of FAAH with IC50 of 8.29 nM. | |
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V71797 | FAAH-IN-8 | 2867633-84-7 | FAAH-IN-8 is a competitive inhibitor of FAAH with IC50 of 6.7 nM and a Ki of 5 nM. |
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V87421 | FAAH-IN-9 | 288862-89-5 | FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM. |
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V71789 | FAAH/cPLA2α-IN-1 | 1696401-38-3 | FAAH/cPLA2α-IN-1 is a dual (bifunctional) inhibitor of FAAH and cPLA2α with IC50 of 32 and 47 nM respectively. |
|
V87247 | FAAH/TRPV1 blocker-1 | FAAH/TRPV1 blocker-1 (compound 2R) is a FAAH/TRPV1 dual blocker with IC50 of 0.12 and 94.9 μM, respectively. | |
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V71792 | FP-Biotin (FP-Biotin) | 259270-28-5 | FP-biotin is a potent organophosphorus poison and is suitable for the search for new biomarkers of organophosphorus poison exposure. |
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V71585 | Isopropyl dodec-11-enylfluorophosphonate (IDEFP) | 623114-64-7 | Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphate that can inhibit the central cannabinoid receptor (CB1) and inhibits FAAH with similar potency (IC 50 = 2 nM). |
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V0910 | JNJ-1661010 | 681136-29-8 | JNJ-1661010 (JNJ 1661010;Takeda-25;JNJ1661010;Takeda25),a piperazinyl phenyl urea compound, is a selective and reversible inhibitor of Fatty acid amide hydrolase/FAAH with important biological activity. |
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V4504 | JNJ-42165279 | 1346528-50-4 | JNJ-42165279 is a novel, potent,covalent and selective FAAH (fatty acid amide hydrolase) inhibitor with IC50 of 70 ± 8 nM and 313 ± 28 nM for hFAAH and rFAAH, respectively. |
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