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Reactive Oxygen Species

Reactive Oxygen Species

Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.

By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.

Reactive Oxygen Species related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Schisandrin B ((+)-Schisandrin B) V72941 (+)-Schisandrin B ((+)-Schisandrin B) 82467-52-5 (+)-Schisandrin B is an enantiomer of Schisandrin B.
(-)-Lyoniresinol 9'-O-glucoside V72973 (-)-Lyoniresinol 9'-O-glucoside 143236-02-6 (-)-Lyoniresinol 9'-O-glucoside is an inhibitor (blocker/antagonist) of ROS.
(E/Z)-GSK5182 V67649 (E/Z)-GSK5182 2699724-40-6 (E/Z)-GSK5182 is the racemate of (E)-GSK5182 and (Z)-GSK5182.
(±)-Carnitine-d9 chloride (DL-Carnitine-d9 (chloride)) V72906 (±)-Carnitine-d9 chloride (DL-Carnitine-d9 (chloride)) 1219386-75-0 (±)-Carnitine-d9 (chloride) is the deuterated form of (±)-Carnitine chloride.
(±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) V72939 (±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) 69097-97-8 (±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) was extracted from Angelica keiskei, a cold-resistant perennial herb of the Apiaceae family.
1,3-Diphenylisobenzofuran (DPBF) V67090 1,3-Diphenylisobenzofuran (DPBF) 5471-63-6 1,3-Diphenylisobenzofuran (DPBF) is used as a selective probe for the detection and quantification of hydrogen peroxide in samples containing different reactive nitrogen and oxygen species (RNOS).
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside V72945 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside 1447969-66-5 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside compound in Lilium brownie var.
2,4,7-Trihydroxy-9,10-dihydrophenanthrene V72921 2,4,7-Trihydroxy-9,10-dihydrophenanthrene 70205-52-6 2,4,7-Trihydroxy-9,10-dihydrophenanthrene is a dihydrophenanthrene analogue that can be found in Pholidota chinensis Lindl.
2-Selenouracil V72904 2-Selenouracil 16724-03-1 2-Selenouracil is an effective photosensitizer used in photodynamic therapy.
3′-Hydroxy-4′-O-methylglabridin V72965 3′-Hydroxy-4′-O-methylglabridin 175554-11-7 3′-Hydroxy-4′-O-methylglabridin is an antioxidant that effectively prevents NADH-dependent peroxidation.
3-Demethylcolchicine V72896 3-Demethylcolchicine 7336-33-6 3-Demethylcolchicine is a metabolite of colchicine.
4-Methyl-6-phenyl-2H-pyranone V72955 4-Methyl-6-phenyl-2H-pyranone 4467-30-5 4-Methyl-6-phenyl-2H-pyranone may be utilized to prepare N-hydroxypyridone analogues that protect astrocytes from hydrogen peroxide-induced toxicity by improving mitochondrial function.
5-Hydroxyoxindole V72910 5-Hydroxyoxindole 3416-18-0 5-Hydroxyoxindole is a structural analog of uric acid.
6-Deoxyjacareubin V72954 6-Deoxyjacareubin 16265-56-8 6-Deoxyjacareubin is a natural xanthone extracted from the leaves of Vismia latifolia.
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) V69158 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) 83182-58-5 8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is an orally bioavailable STAT3 inhibitor.
AHK V72967 AHK 126828-32-8 AHK is a biologically active peptide with antioxidant effects and has been reported to be used as an ingredient of cosmetics.
Allyl methyl trisulfide V72928 Allyl methyl trisulfide 34135-85-8 Allyl methyl trisulfide is a volatile organic/chemical reagent and a component of garlic (Allium sativum L.
Aminoguanidine hemisulfate V73391 Aminoguanidine hemisulfate 996-19-0 Aminoguanidine hemisulfate is an inhibitor (blocker/antagonist) of NOS and ROS.
Anemarrhenasaponin Ia (Anemarrhenasaponin IA) V72947 Anemarrhenasaponin Ia (Anemarrhenasaponin IA) 221317-02-8 Anemarrhenasaponin Ia can be extracted from Anemarrhenae rhizome and inhibits the further production of superoxide induced by fMLP.
Anti-inflammatory agent 38 V77255 Anti-inflammatory agent 38 Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 inhibitor (antagonist) with IC50 of 0.38 μM for NO.
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