Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V29322 | 10-Deacetyltaxol | 78432-77-6 | 10-Deacetyltaxol (also called 10-Deacetylpaclitaxel), the 10-deacetylated form of paclitaxel, is a taxane analogue andimpurity of Paclitaxel extracted from Taxus wallichiana Zucc with anticancer activities. |
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V34036 | 7-epi-Taxol | 105454-04-4 | 7-epi-Taxol, the epimer of taxol (paclitaxel), is a major and active metabolite of taxol isolated fromTaxus brevifolia with comparable anticancr/antitubulin activityto that of paclitaxek/taxol. |
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V35084 | Amiprofos methyl (BAY-NTN 6867) | 36001-88-4 | Amiprofos methyl (BAY-NTN 6867) is a phosphate amide herbicide. |
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V51606 | Ansamitocin analog (20-O-Demethyl-AP3) | 72902-38-6 | Ansamitocin analog (20-O-Demethyl-AP3) is one of ansamitocin P-3's minor metabolites. |
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V29720 | Ansamitocin P-3 (Antibiotic C 15003P3'; Maytansinol butyrate) | 66584-72-3 | Ansamitocin P-3 (Maytansinol isobutyrate; NSC-292222;Antibiotic C 15003P3) is a potent microtubule/antimitotic inhibitor used as an warhead of ADC (antibody drug conjugate). |
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V78086 | Anti-α-Tubulin Antibody, AF555 conjugate | Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody (mAb) and the red fluorescent dye Alexa Fluor 555, which may be utilized to detect tubulin (Ex/Em: 554/567 nm). | |
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V77986 | Anticancer agent 139 | Anticancer agent 139 (Compound 6h) has potent anti-cancer activity. | |
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V34998 | Anticancer agent 98 | 2857070-72-3 | Anticancer agent 98 (compound 12k) is a tubulin polymerization inhibitor (Kd=16.9 μM). |
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V34829 | Antiproliferative agent-14 | 1885900-35-5 | antiproliferation agent-14 (compound 3b) is a potent inhibitor of tubulin polymerization with IC50 of 3.41 μM. |
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V78056 | Antiproliferative agent-23 | antiproliferation agent-23 is a microtubule destabilizing agent (MDA) that effectively interferes with the tubulin-microtubule system. | |
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V55250 | Antiproliferative agent-30 | 2713553-88-7 | antiproliferation agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. |
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V79807 | Antitubulin agent 1 | Antitubulin agents-1 is an antitubulin agent that induces disruption of microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. | |
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V5180 | Auristatin E | 160800-57-7 | Auristatin E,a synthetic analog of dolastatin 10, is a novel and highly cytotoxic tubulin inhibitor with antitumor activity; it is a MMAE analog and cytotoxin used in Antibody-drug conjugates. |
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V52340 | Bis-ANS dipotassium | 65664-81-5 | Bis-ANS dipotassium is a protein fluorescent probe. |
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V13004 | BNC-105 | 945771-74-4 | BNC105 is a potentbenzofuran-basedtubulin polymerization inhibitor and also avascular disrupting agent (VDA) prodrug with potential anti-vascular and anticancer activities. |
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V3229 | BTB-1 | 86030-08-2 | BTB-1 is a novel, potent and the first small molecule inhibitor of the mitotic motor protein Kif18A. |
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V52300 | Cantuzumab mertansine (mocantuzumab; SB-408075; huC242-DM1) | 400010-39-1 | Cantuzumab mertansine (SB-408075; huC242-DM1) is an ADC that is an immunoconjugate of a potent maytansine analogue and a humanized monoclonal antibody (mAb) against CanAg (huC242). |
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V52299 | Cantuzumab ravtansine (IMGN242; huC242-DM4) | 868747-45-9 | Cantuzumab ravtansine (IMGN242; huC242-DM4) is an ADC consisting of a humanized monoclonal antibody (mAb), huC242, covalently linked to DM4 via a disulfide bond. |
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V17952 | Cevipabulin | 849550-05-6 | Cevipabulin (formerly D-06576;TTI-237) is a triazolopyrimidine based microtubule targeting agent/tubulin inhibitor with potential antitumor activity. |
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V55261 | cis-Trismethoxy resveratrol ((Z)-3,5,4'-Trimethoxystilbene) | 94608-23-8 | Cis-trismethoxy resveratrol is a potent antimitotic active that can inhibit tubulin polymerization with IC50 of 4 μM. |
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