Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V29322 | 10-Deacetyltaxol | 78432-77-6 | 10-Deacetyltaxol (also called 10-Deacetylpaclitaxel), the 10-deacetylated form of paclitaxel, is a taxane analogue andimpurity of Paclitaxel extracted from Taxus wallichiana Zucc with anticancer activities. | |
V84553 | 3,4',5-Trismethoxybenzophenone | 94709-12-3 | ||
V34036 | 7-epi-Taxol | 105454-04-4 | 7-epi-Taxol, the epimer of taxol (paclitaxel), is a major and active metabolite of taxol isolated fromTaxus brevifolia with comparable anticancr/antitubulin activityto that of paclitaxek/taxol. | |
V88427 | ABT-751 hydrochloride | 141450-48-8 | ABT-751 (E7010) hydrochloride is a novel, highly orally bioavailable sulfonamide antimitotic compound and tubulin binding agent. | |
V88374 | ADC Control Human IgG1-vcMMAE | ADC Control Human IgG1-vcMMAE is a human monoclonal antibody, which is the isotype control of ADC human IgG1-vcMMAE and can inhibit tubulin polymerization. | ||
V88371 | ADC Control Human IgG1-vcMMAF | ADC Control Human IgG1-vcMMAF is a human monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit tubulin polymerization. | ||
V84913 | AM-9022 | 2446872-46-2 | AM-9022 is an orally active, potent and selective KIF18A inhibitor that can be used in cancer research. | |
V35084 | Amiprofos methyl (BAY-NTN 6867) | 36001-88-4 | Amiprofos methyl (BAY-NTN 6867) is a phosphate amide herbicide. | |
V51606 | Ansamitocin analog (20-O-Demethyl-AP3) | 72902-38-6 | Ansamitocin analog (20-O-Demethyl-AP3) is one of ansamitocin P-3's minor metabolites. | |
V29720 | Ansamitocin P-3 (Antibiotic C 15003P3'; Maytansinol butyrate) | 66584-72-3 | Ansamitocin P-3 (Maytansinol isobutyrate; NSC-292222;Antibiotic C 15003P3) is a potent microtubule/antimitotic inhibitor used as an warhead of ADC (antibody drug conjugate). | |
V78086 | Anti-α-Tubulin Antibody, AF555 conjugate | Anti-α-Tubulin Antibody, AF555 conjugate is a conjugate of mouse anti-α-tubulin monoclonal antibody (mAb) and the red fluorescent dye Alexa Fluor 555, which may be utilized to detect tubulin (Ex/Em: 554/567 nm). | ||
V77986 | Anticancer agent 139 | Anticancer agent 139 (Compound 6h) has potent anti-cancer activity. | ||
V34998 | Anticancer agent 98 | 2857070-72-3 | Anticancer agent 98 (compound 12k) is a tubulin polymerization inhibitor (Kd=16.9 μM). | |
V34829 | Antiproliferative agent-14 | 1885900-35-5 | antiproliferation agent-14 (compound 3b) is a potent inhibitor of tubulin polymerization with IC50 of 3.41 μM. | |
V78056 | Antiproliferative agent-23 | antiproliferation agent-23 is a microtubule destabilizing agent (MDA) that effectively interferes with the tubulin-microtubule system. | ||
V55250 | Antiproliferative agent-30 | 2713553-88-7 | antiproliferation agent-30 (Compound 8g) inhibits tubulin assembly and inhibits FLT3 and Abl1. | |
V79807 | Antitubulin agent 1 | Antitubulin agents-1 is an antitubulin agent that induces disruption of microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. | ||
V83574 | Antitumor agent-138 | 2975168-22-8 | ||
V88701 | Antitumor agent-155 | Antitumor agent-155 (Compound 13) inhibits microtubule polymerization and induces cell autophagy and apoptosis. | ||
V88697 | Antitumor agent-164 | 2757188-21-7 | Antitumor agent-164 (compound 60c) is a colchicine binding site inhibitor (CBSI) with efficacy in taxane-sensitive TNBC. |