YAP

YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Structure Cat No. Product Name CAS No. Product Description
V69181 (R)-VT104 2417718-26-2
V79706 AF-2112
V69180 DC-TEADin02 2380228-45-3
V12043 GA-017 2351906-74-4 GA 017 is a novel,potent and selective inhibitor ofLATS1 and LATS2 (large tumor suppressor kinase 1/2).
V69176 GNE-7883 2648450-42-2
V69175 IK-930 2563892-44-2
V79966 LM-41
V79664 mCMY020
V78452 MY-1076
V2270 MYF-01-37 2416417-65-5 MYF-01-37 is a novel, potent and covalent TEAD inhibitor with anticancer activity.
V3198 Super-TDU 1599441-71-0 Super-TDU is a rationally designed peptide-based inhibitor targeting the YAP-TEADs interaction by mimicking the VGLL with anticancer activity.
V81480 Super-TDU (1-31)
V76465 Super-TDU (1-31) (TFA)
V81481 Super-TDU TFA
V69179 SWTX-143 2766575-48-6
V69183 TEAD-IN-6 2821763-12-4
V38733 TED-347 2378626-29-8 TED-347 (TED347) is a novel,covalent/irreversible,and allostericYAP-TEAD protein-protein interaction inhibitor with anticancer activity.
V69174 TRULI (Lats-IN-1) 1424635-83-5
V69178 TT-10 (TAZ-K) 2230640-94-3
V76351 VT02956
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