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YAP

YAP

YAP (Yes-associated protein) regulates cell growth, tissue homeostasis, and organ size as a transcription co-activator in the Hippo tumor suppressor pathway. The kinase Lats inhibits YAP by phosphorylating it, causing it to localize to the cytoplasm and be degraded by proteasomes. By attaching to transcription factors from the TEAD family, YAP stimulates the expression of genes.

YAP has a complicated role in human cancer that may vary depending on the cell type. For instance, by inducing apoptosis in response to DNA damage, YAP may act as a tumor suppressor in some cell types, such as hematological cancers.

YAP related products

Structure Cat No. Product Name CAS No. Product Description
(7S)-BAY-593 V91788 (7S)-BAY-593 2413068-25-2 (7S)-BAY-593 is the S-isomer of BAY-593.
(R)-VT104 V69181 (R)-VT-104 2417718-26-2 (R)-VT104 is the R-enantiomer of VT104.
(R,S)-YAP-TEAD-IN-2 V115702 (R,S)-YAP-TEAD-IN-2 (R,S)-YAP-TEAD-IN-2 is a racemic variant of YAP-TEAD-IN-2.
AF-2112 V79706 AF-2112 AF-2112 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
BAY-593 V88143 BAY-593 2413020-56-9 BAY-593 is an orally active GGTase-I inhibitor.
BAY-593 hydrochloride V103840 BAY-593 hydrochloride 2413020-57-0 BAY-593 (hydrochloride) is an orally available GGTase-I inhibitor.
Cardiomyocyte proliferation promoting agent-1 V118488 Cardiomyocyte proliferation promoting agent-1 2351906-71-1 Cardiomyocyte proliferation promoter-1 ((E/Z)-GA-002) is an E/Z mixture that promotes cardiomyocyte proliferation.
DC-TEAD3in03 V115142 DC-TEAD3in03 DC-TEAD3in03 is a subtype-selective covalent TEAD3 inhibitor with an IC50 value of 0.16 μM.
DC-TEADin02 V69180 DC-TEADin02 2380228-45-3 DC-TEADin02 is a potent inhibitor of TEAD autopalmitoylation.
EA-C15 V113177 EA-C15 EA-C15 is a highly effective and selective TEAD inhibitor with an IC50 value of 0.34 μM.
GA-017 V12043 GA-017 2351906-74-4 GA-017 is a potent and specific LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor (antagonist) with IC50s of 4.10 and 3.92 nM, respectively.
GNE-7883 V69176 GNE-7883 2648450-42-2 GNE-7883 is a generic TEAD inhibitor (antagonist) with anti-cell proliferation/growth activity.
HC-258 V85993 HC-258
IAG933 V69177 IAG933 2714434-21-4 IAG933 (YAP-TEAD-IN-3; compound 155) is a YAP/TAZ-TEAD inhibitor.
IK-930 V69175 IK-930 2563892-44-2 IK-930 (compound I-32) is a potent orally bioactive TEAD inhibitor (antagonist) with EC50 <0.1 µM.
LATS-IN-2 V117485 LATS-IN-2 2248728-49-4 LATS-IN-2 is a potent LATS inhibitor.
LATS1/2-IN-1 V118692 LATS1/2-IN-1 3024011-99-9 LATS1/2-IN-1 is a highly effective and selective inhibitor of LATS1 and LATS2.
LM-41 V79966 LM-41 2996821-30-6 LM-41 is a Flufenamic acid-derived TEAD inhibitor that strongly reduces the expression of CTGF, Cyr61, Axl, and NF2.
mCMY020 V79664 mCMY020 mCMY020 is a TEAD covalent inhibitor.
MSC-1254 V94432 MSC-1254 MSC-1254 is a reversible, selective and covalent TEAD1 inhibitor.
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