Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe).Wee1, a key regulator of cell cycle progression, has a molecular mass of 96 kDa. Wee1 alters cell size by preventing Cdk1 from triggering mitosis, which prevents cell division. Numerous other organisms, including mammals, have wee1 homologues. Wee1 inhibits Cdk1 by phosphorylating it at Tyr15 and Thr14, two different sites. Cdk1 is essential for the various cell cycle checkpoints' cyclin-dependent passage. The inhibition of Cdk1 by Wee1 is critical for at least three checkpoints, including the G2/M checkpoint, cell size checkpoint, and DNA damage checkpoint. It has been demonstrated that Wee1 regulates the overall expression of histones by phosphorylating histone H2B at the tyrosine 37 residue.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75886 | LEB-03-144 | 2858812-89-0 | LEB-03-144 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a C3 alkyl linker. |
|
V75888 | LEB-03-145 | 2858812-90-3 | LEB-03-145 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a C5 alkyl linker. |
|
V75887 | LEB-03-146 | 2858812-91-4 | LEB-03-146 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a PEG2 linker. |
|
V75889 | LEB-03-153 | 2858812-88-9 | LEB-03-153 is a WEE1 DUBTAC/deubiquitinating enzyme targeting chimera tethering adavosertib (AZD1775) to the OTUB1 recruiter EN523 via a linker-free linker. |
|
V85064 | Myt1-IN-4 | ||
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V88803 | PKMYT1-IN-2 | 3033609-84-3 | PKMYT1-IN-2 (compound 2) is a potent PKMYT1 inhibitor with IC50 of 5.7 nM. |
|
V1588 | Adavosertib (AZD-1775; MK-1775) | 955365-80-7 | Adavosertib (formerly known as AZD-1775; MK-1775; AZD1775; MK1775) is a novel potent and selective small molecule Wee1 tyrosine kinase inhibitor with potential anticancer activity. |
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V88805 | WEE1-IN-10 | 2226938-19-6 | WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. |
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V2255 | WEE1-IN-3 | 2272976-28-8 | WEE1-IN-3 is a potent inhibitor of Wee1 kinase with IC50 <10 nM. |
|
V88804 | WEE1-IN-6 | 2928524-08-5 | WEE1-IN-6 (compound 110) is an orally active WEE1 inhibitor with a DC50 value of ≤ 100 nM. |
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