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ROR

ROR

Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and a member of the orphan nuclear receptor family. Three members of the ROR subfamily—ROR (NR1F1), ROR (NR1F2), and ROR (NR1F3)—are ligand-dependent transcription factors.
According to reports, RORs play a role in the development of secondary lymphoid tissues, autoimmune and inflammatory diseases, the circadian rhythm, and metabolism homeostasis. They are also thought to activate transcription through ligand-dependent interactions with co-regulators.
Important immune system regulators include ROR and ROR. These elements are necessary for the growth and differentiation of Th17 cells. Inflammation and autoimmune disease are facilitated by ROR, which is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and  T cells.

ROR related products

Structure Cat No. Product Name CAS No. Product Description
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid; 3-oxoLCA) V67790 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid; 3-oxoLCA) 1553-56-6 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits TH17 cell differentiation by directly binding to the key transcription factor RORγt (Kd=1.13 μM).
7ß,27-Dihydroxycholesterol (7β, 27-OHC) V67809 7ß,27-Dihydroxycholesterol (7β, 27-OHC) 240129-43-5 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and specific RORγt agonist (Ki=120 nM).
Antitumor agent-127 V85431 Antitumor agent-127
Bevurogant (BI 730357) V67791 Bevurogant (BI 730357) 1817773-66-2 Bevurogant (BI 730357) is a retinoid-related orphan receptor-γt (RORγt) antagonist.
GSK2981278 V2953 GSK2981278 1474110-21-8 GSK2981278 (GSK-2981278; GSK 2981278) is a novel, potent and selective inverse agonist of RORγ (retinoid-related orphan receptor gamma) with potential anti-inflammatory and immumomodulatory activity (e.
GSK805 V3596 GSK805 1426802-50-7 GSK805 (GSK-805) is a novel, potent, and orally bioavailable RORγt inhibitor with the potential to be used for autoimmune encephalomyelitis (EAE).
Izumerogant (IMU-935) V67799 Izumerogant (IMU-935) 2299252-72-3 Izumerogant (IMU-935) is a retinoic acid-related orphan receptor-γ (RORγ) inhibitor.
JNJ-61803534 V67805 JNJ-61803534 1917306-14-9 JNJ-61803534 is a potent, orally bioactive RORγt inverse agonist/activator with IC50 of 9.6 nM.
JTE-151 V67789 JTE-151 1404380-58-0 JTE-151 is a RORγ inhibitor that can inhibit overactive immune responses by inhibiting RORγ related to Th17 cell activation, making JTE-151 potentially useful in the research of autoimmune diseases.
PF-06747711 V4466 PF-06747711 1892576-58-7 PF-06747711 (PF06747711) is a novel, potent, selective, and orally bioactive retinoic acid receptor-related orphan C2 (RORC2, also known asRORγt) inverse agonist with anti-skin inflammatory activity.
Retezorogant V67798 Retezorogant 1950570-48-5 Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist disclosed in patent WO2016093342 A1.
RORγ agonist 1 V67793 RORγ agonist 1 2260631-91-0 RORγ agonist 1 is a potent orally bioavailable RORγ agonist (EC50 = 21 nM) with anti-tumor effects.
RORγ antagonist 1 V81322 RORγ antagonist 1 RORγ antagonist 1 (compound 22) is a potent betulinic acid analogue and an antagonist of RORγ (KD=0.18 μM).
RORγ inverse agonist 1 V67804 RORγ inverse agonist 1 529500-72-9 RORγ inverse agonist 1 is the inverse agonist of RORγ.
RORγt agonist 1 V67795 RORγt agonist 1 2377378-89-5 RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist/activator with EC50 of 20.8 nM.
RORγt agonist 4 V67788 RORγt agonist 4 2241769-59-3 RORγt agonist 4 (compound 14) is a potent selective RORγt agonist.
RORγt inhibitor 1 V67794 RORγt inhibitor 1 1561770-72-6 RORγt inhibitor 1 is an allosteric inhibitor of RORγt with IC50 of 1 nM.
RORγt Inverse agonist 10 V67810 RORγt Inverse agonist 10 2413986-35-1 RORγt Inverse agonist 10 is a potent, orally bioactive RORγt inverse agonist/activator with IC50 of 51 nM.
RORγt inverse agonist 13 V67807 RORγt inverse agonist 13 2170477-75-3 RORγt inverse agonist 13 (Compound 3i) is a potent, orally bioactive, selective RORγt inverse agonist/activator with IC50 of 63.8 nM.
RORγt inverse agonist 14 V67792 RORγt inverse agonist 14 2672496-70-5 RORγt inverse agonist 14 (8e) is a potent, orally bioactive, selective inverse agonist of RORγt (EC50 of 2.5 nM) with anti-inflammatory activity.
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