Retinoic acid receptor-related orphan receptors (RORs) are a subfamily of the thyroid hormone receptor, which is a subfamily of the nuclear receptors and a member of the orphan nuclear receptor family. Three members of the ROR subfamily—ROR (NR1F1), ROR (NR1F2), and ROR (NR1F3)—are ligand-dependent transcription factors.
According to reports, RORs play a role in the development of secondary lymphoid tissues, autoimmune and inflammatory diseases, the circadian rhythm, and metabolism homeostasis. They are also thought to activate transcription through ligand-dependent interactions with co-regulators.
Important immune system regulators include ROR and ROR. These elements are necessary for the growth and differentiation of Th17 cells. Inflammation and autoimmune disease are facilitated by ROR, which is expressed in lymphoid tissue inducer cells, innate lymphoid cells, invariant natural killer T cells, and T cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V67790 | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid; 3-oxoLCA) | 1553-56-6 | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits TH17 cell differentiation by directly binding to the key transcription factor RORγt (Kd=1.13 μM). |
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V67809 | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) | 240129-43-5 | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and specific RORγt agonist (Ki=120 nM). |
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V67791 | Bevurogant (BI 730357) | 1817773-66-2 | Bevurogant (BI 730357) is a retinoid-related orphan receptor-γt (RORγt) antagonist. |
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V2953 | GSK2981278 | 1474110-21-8 | GSK2981278 (GSK-2981278; GSK 2981278) is a novel, potent and selective inverse agonist of RORγ (retinoid-related orphan receptor gamma) with potential anti-inflammatory and immumomodulatory activity (e. |
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V3596 | GSK805 | 1426802-50-7 | GSK805 (GSK-805) is a novel, potent, and orally bioavailable RORγt inhibitor with the potential to be used for autoimmune encephalomyelitis (EAE). |
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V67799 | Izumerogant (IMU-935) | 2299252-72-3 | Izumerogant (IMU-935) is a retinoic acid-related orphan receptor-γ (RORγ) inhibitor. |
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V67805 | JNJ-61803534 | 1917306-14-9 | JNJ-61803534 is a potent, orally bioactive RORγt inverse agonist/activator with IC50 of 9.6 nM. |
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V67789 | JTE-151 | 1404380-58-0 | JTE-151 is a RORγ inhibitor that can inhibit overactive immune responses by inhibiting RORγ related to Th17 cell activation, making JTE-151 potentially useful in the research of autoimmune diseases. |
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V4466 | PF-06747711 | 1892576-58-7 | PF-06747711 (PF06747711) is a novel, potent, selective, and orally bioactive retinoic acid receptor-related orphan C2 (RORC2, also known asRORγt) inverse agonist with anti-skin inflammatory activity. |
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V67798 | Retezorogant | 1950570-48-5 | Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist disclosed in patent WO2016093342 A1. |
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V67793 | RORγ agonist 1 | 2260631-91-0 | RORγ agonist 1 is a potent orally bioavailable RORγ agonist (EC50 = 21 nM) with anti-tumor effects. |
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V81322 | RORγ antagonist 1 | RORγ antagonist 1 (compound 22) is a potent betulinic acid analogue and an antagonist of RORγ (KD=0.18 μM). | |
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V67804 | RORγ inverse agonist 1 | 529500-72-9 | RORγ inverse agonist 1 is the inverse agonist of RORγ. |
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V67795 | RORγt agonist 1 | 2377378-89-5 | RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist/activator with EC50 of 20.8 nM. |
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V67788 | RORγt agonist 4 | 2241769-59-3 | RORγt agonist 4 (compound 14) is a potent selective RORγt agonist. |
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V67794 | RORγt inhibitor 1 | 1561770-72-6 | RORγt inhibitor 1 is an allosteric inhibitor of RORγt with IC50 of 1 nM. |
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V67810 | RORγt Inverse agonist 10 | 2413986-35-1 | RORγt Inverse agonist 10 is a potent, orally bioactive RORγt inverse agonist/activator with IC50 of 51 nM. |
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V67807 | RORγt inverse agonist 13 | 2170477-75-3 | RORγt inverse agonist 13 (Compound 3i) is a potent, orally bioactive, selective RORγt inverse agonist/activator with IC50 of 63.8 nM. |
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V67792 | RORγt inverse agonist 14 | 2672496-70-5 | RORγt inverse agonist 14 (8e) is a potent, orally bioactive, selective inverse agonist of RORγt (EC50 of 2.5 nM) with anti-inflammatory activity. |
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V67797 | RORγt inverse agonist 23 | 2230779-18-5 | RORγt inverse agonist 23 is a potent, selective and oral novel RORγt inverse agonist. |
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