As the primary component of the amyloid plaques seen in the brains of Alzheimer patients, amyloid- (A) refers to peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease. The amyloid precursor protein (APP), which is cut by specific enzymes to produce A, produces the peptides. Amyloid molecules can group together to create a variety of flexible, soluble oligomers.A amyloid-peptide buildup results from excessive A production or malfunctioning clearance mechanisms. Amyloid- forms diffuse and neuritic plaques in the parenchyma and blood vessels by self-aggregating into oligomers of various sizes. Strong synaptotoxins, proteasome inhibition, mitochondrial inhibition, alteration of intracellular Ca2+ levels, and induction of inflammatory processes are all characteristics of amyloid-oligomers and plaques. Neuronal dysfunction is also thought to be influenced by the loss of A's typical physiological functions.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V33327 | (2-Hydroxypropyl)-β-cyclodextrin | 128446-35-5 | 2-Hydroxypropyl)-β-cyclodextrin is a cyclodextrin oligosaccharide that has beenwidely used drug delivery vehicle to improve the aqueous solubility,stability and bioavailability of chemical compounds. |
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V71423 | (Asp37)-Amyloid β-Protein (1-42) | 1875128-79-2 | (Asp37)-Amyloid beta-Protein (1-42) is the G37D mutant of the wild-type Amyloid-beta (1-42) peptide. |
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V71427 | (D-Asp1)-Amyloid β-Protein (1-42) | 1802086-19-6 | (D-Asp1)-Amyloid β-Protein (1-42) is a bioactive peptide fragment of amyloid β protein (Aβ). |
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V71408 | (Gln22)-Amyloid β-Protein (1-42) | 147335-12-4 | (Gln22)-Amyloid β-Protein (1-42) is a Dutch mutant (E22Q) form of β-Amyloid (1-42). |
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V71384 | (Gln22,Asn23)-Amyloid β-Protein (1-40) | 374796-75-5 | (Gln22,Asn23)-Amyloid β-Protein (1-40) is a bioactive peptide. |
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V71391 | (Glu20)-Amyloid β-Protein (1-42) | 1802086-22-1 | (Glu20)-Amyloid β-Protein (1-42) is a slower fibrillating variant of amyloid β-protein (Aβ). |
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V71394 | (Gly22)-amyloid beta-protein(1-40) | 175010-18-1 | (Gly22)-amyloid beta-protein(1-40) (Arctic variant Ab40ARC (E22G)) is a bioactive peptide. |
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V71406 | (Gly22)-Amyloid β-Protein (1-42) | 1802086-23-2 | (Gly22)-Amyloid β-Protein (1-42) is a bioactive peptide fragment of the amyloid β-protein (Aβ). |
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V71417 | (Lys22)-Amyloid β-Protein (1-42) | 383200-59-7 | (Lys22)-Amyloid β-Protein (1-42) is a mutation of the WT Amyloid β-Protein (1-42) peptide. |
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V77422 | (Met(O)35)-Amyloid β-Protein (1-42) | (Met(O)35)-Amyloid β-Protein (1-42) is the oxidized form of Aβ42 (Met35 site). | |
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V77423 | (Met(O2)35)-Amyloid β-Protein (1-42) | (Met(O2)35)-Amyloid β-Protein (1-42) is a polypeptide. | |
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V77424 | (Nle35)-Amyloid β-Protein (1-42) (ammonium) | (Nle35)-Amyloid β-Protein (1-42) ammonium is a bioactive peptide. | |
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V71393 | (Pyr11)-Amyloid β-Protein (11-40) | 192377-94-9 | (Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) is a bioactive peptide. |
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V77426 | (Pyr3)-Amyloid β-Protein (3-42) (TFA) | (Pyr3)-Amyloid β-Protein (3-42) TFA is the major amyloid β peptide structure deposited in the brains of patients with AD/Alzheimer's disease and Down syndrome. | |
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V71402 | (Val2)-Amyloid β-Protein (1-6) | 727727-66-4 | (Val2)-Amyloid β-Protein (1-6) is a bioactive peptide discovered by peptide screening. |
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V71438 | 2,3-Dehydrosilybin A | 25166-14-7 | 2,3-Dehydrosilybin A is a longevity-promoting and anti-aggregation compound. |
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V71371 | 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 | 1331662-16-8 | 2-Hydroxy-5-(phenyldiazenyl)benzoic acid-d5 is deuterated labeled 2-Hydroxy-5-(phenyldiazenyl)benzoic acid. |
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V77649 | 5-FAM-β-Amyloid (1-28) (5-FAM-Amyloid β-protein (1-28)) | 5-FAM-β-Amyloid (1-28) is a fluorescently labeled β-Amyloid (1-28). | |
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V77650 | 5-FAM-β-Amyloid (1-42), human TFA (5-FAM-Amyloid β-peptide (1-42) (human) TFA) | 5-FAM-β-Amyloid (1-42), human (5-FAM-Amyloid β-peptide (1-42) (human) TFA is a 5-FAM-labeled β-Amyloid (1-42), human (TFA). | |
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V71396 | 5-TAMRA-Amyloid β-Protein (1-40) | 1802087-81-5 | 5-TAMRA-Amyloid β-Protein (1-40) is fluorescent (TAMRA) labeled amyloid β-protein (Amyloid β-Protein) (1-40), Abs/Em=544/572 nm. |
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