Formyl peptide receptors (FPRs), which include FPR1, FPR2, and FPR3, are a class of G protein-coupled chemoattractant receptors. While FPR3 is present in monocytes but not neutrophils, FPR1 and FPR2 are expressed in both monocytes and neutrophils. FPR1 is expressed in astrocytes, microglial cells, hepatocytes, and immature dendritic cells in addition to myeloid cells. FPR2 is expressed in a variety of non-myeloid cells, including astrocytoma cells, epithelial cells, hepatocytes, microvascular endothelial cells, neuroblastoma cells, as well as phagocytic leukocytes, and exhibits an even wider distribution pattern than FPR1.Due to their capacity to distinguish between pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), FPRs are categorized as Pathogen Recognition Receptors (PRRs) found on immune cells. These receptors are important in innate immunity. Due to their distinct binding characteristics and interactions with structurally diverse ligands, FPRs play a role in a number of physio-pathological processes, including migration, proliferation, the production of superoxide, and host defense and inflammatory response regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75351 | Ac9-25 | 284040-76-2 | Ac9-25, an N-terminal peptide of annexin I, is a formyl peptide receptor (FPR) agonist and activates neutrophil NADPH oxidase through FPR. |
|
V77731 | Ac9-25 TFA | Ac9-25 TFA, an N-terminal peptide of annexin I, is a formyl peptide receptor (FPR) agonist and activates neutrophil NADPH oxidase through FPR. | |
|
V75345 | ACT-389949 | 1258417-54-7 | ACT-389949 is a first-in-class, highly effective and selective formyl peptide receptor 2/lipoprotein A4 receptor (FPR2)/(ALX) agonist. |
|
V86018 | ADS051 (BT051) | ||
|
V75344 | BMS-986235 (LAR-1219) | 2253947-47-4 | BMS-986235 (LAR-1219) is a selective, orally bioactive formyl peptide receptor 2 (FPR2) agonist/activator with EC50s of 0.41 nM and 3.4 nM for human FPR2 and mouse FPR2, respectively. |
|
V84666 | Boc-MLF (Boc-Met-Leu-Phe-OH) | 67247-12-5 | |
|
V77192 | Boc-MLF TFA (Boc-Met-Leu-Phe-OH TFA) | Boc-MLF (TFA) is a bioactive peptide that is a formyl peptide receptor (FPR) antagonist. | |
|
V2048 | Cyclosporine H | 83602-39-5 | Cyclosporin H is a naturally occuring cyclic undecapeptide, acting as a potent TPA/PMA (tumor promoting phorbol ester) inhibitor and a selective inhibitor of formyl peptide receptors (FPR-1) with Ki of 0.1 uM. |
|
V75350 | FPR-A14 | 329691-12-5 | FPR-A14 is a potent formyl peptide receptor (FPR) agonist. |
|
V78910 | FPR1 antagonist 1 | FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist (inhibitor) with IC50 of 25 nM. | |
|
V78885 | FPR1 antagonist 2 | FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist (inhibitor) with IC50 of 70 nM. | |
|
V75346 | FPR2 agonist 3 | 2829263-19-4 | FPR2 agonist 3 limits the release of lactate dehydrogenase in LPS-stimulated cultures and reduces the levels of pro-inflammatory IL-1β and IL-6? FPR2 agonist 3 reduces the level of phosphorylated STAT3 through the STAT3/SOCS3 signaling pathway. |
|
V75352 | N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) | 2918767-97-0 | N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist. |
|
V86601 | SHAAGtide | SHAAGtide is a FPRL1 activator. | |
|
V15920 | TC-FPR-43 | 903895-98-7 | FPR Agonist 43 (compound 43) is a potent dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist. |
|
V75348 | WKYMVM-NH2 TFA | 1435781-74-0 | WKYMVM-NH2 TFA is a potent agonist of N-formyl peptide receptors FPR1 and FPRL1/2, and can also activate some leukocyte effector functions, such as chemotaxis, activation of complement receptor-3 and NADPH oxidase. |
|
V75343 | WRW4 | 878557-55-2 | WRW4 is a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibiting WKYMVm and FPRL1 with IC50 of 0.23 μM. |
|
V81756 | WRW4 TFA | WRW4 TFA is a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibiting WKYMVm and FPRL1 with IC50 of 0.23 μM. | |
|
V75347 | WRW4-OH | 722541-91-5 | WRW4-OH is a biologically active peptide. |
|
V75349 | {Boc}-Phe-Leu-Phe-Leu-Phe | 66556-73-8 | {Boc}-Phe-Leu-Phe-Leu-Phe ({Boc}-FLFLF) is a formyl peptide receptor (FPR) family antagonist that preferentially inhibits activity triggered through formyl peptide receptors. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
