Formyl peptide receptors (FPRs), which include FPR1, FPR2, and FPR3, are a class of G protein-coupled chemoattractant receptors. While FPR3 is present in monocytes but not neutrophils, FPR1 and FPR2 are expressed in both monocytes and neutrophils. FPR1 is expressed in astrocytes, microglial cells, hepatocytes, and immature dendritic cells in addition to myeloid cells. FPR2 is expressed in a variety of non-myeloid cells, including astrocytoma cells, epithelial cells, hepatocytes, microvascular endothelial cells, neuroblastoma cells, as well as phagocytic leukocytes, and exhibits an even wider distribution pattern than FPR1.Due to their capacity to distinguish between pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), FPRs are categorized as Pathogen Recognition Receptors (PRRs) found on immune cells. These receptors are important in innate immunity. Due to their distinct binding characteristics and interactions with structurally diverse ligands, FPRs play a role in a number of physio-pathological processes, including migration, proliferation, the production of superoxide, and host defense and inflammatory response regulation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V126298 | 4-Bromobiphenyl-d5 | 51624-40-9 | |
![[Leu144]-PLP (139-151)](http://www.invivochem.com/upload/1124/V122419.png)
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V122419 | [Leu144]-PLP (139-151) | 202462-61-1 | [Leu144]-PLP (139-151) is a peptide ligand for the T cell receptor. |
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V115207 | Ac2-26 (mouse) | 164466-66-4 | Ac2-26 (mouse) is the N-terminal active peptide of annexin A1 (AnxA1). |
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V75351 | Ac9-25 | 284040-76-2 | Ac9-25, an N-terminal peptide of annexin I, is a formyl peptide receptor (FPR) agonist and activates neutrophil NADPH oxidase through FPR. |
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V77731 | Ac9-25 TFA | Ac9-25 TFA, an N-terminal peptide of annexin I, is a formyl peptide receptor (FPR) agonist and activates neutrophil NADPH oxidase through FPR. | |
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V75345 | ACT-389949 | 1258417-54-7 | ACT-389949 is a first-in-class, highly effective and selective formyl peptide receptor 2/lipoprotein A4 receptor (FPR2)/(ALX) agonist. |
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V86018 | ADS051 (BT051) | ||
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V107023 | ALXR-agonist-6 | 325850-26-8 | ALXR-agonist-6 (Compound 36) is an ALXR agonist that induces Ca2+ influx with an EC50 value >10 μM in CHO recombinant cells co-expressing hFPRL1. |
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V128857 | Annexuzlimab | Annexuzlimab is a humanized IgG1 monoclonal antibody that specifically binds to ANXA1, thereby blocking its interaction with formyl peptide receptors 1 and 2 (FPR1/2). | |
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V129458 | ART160 | ART160 is a monoclonal antibody against the N-terminal 20-peptide (PAMP) of proadrenal medullaris. | |
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V75344 | BMS-986235 (LAR-1219) | 2253947-47-4 | BMS-986235 (LAR-1219) is a selective, orally bioactive formyl peptide receptor 2 (FPR2) agonist/activator with EC50s of 0.41 nM and 3.4 nM for human FPR2 and mouse FPR2, respectively. |
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V130438 | BOC-FlFlF TFA | BOC-FlFlF TFA is a selective FPR1 antagonist. | |
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V84666 | Boc-MLF (Boc-Met-Leu-Phe-OH) | 67247-12-5 | |
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V77192 | Boc-MLF TFA (Boc-Met-Leu-Phe-OH TFA) | Boc-MLF (TFA) is a bioactive peptide that is a formyl peptide receptor (FPR) antagonist. | |
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V131431 | cFLFLF | 1000977-62-7 | cFLFLF is an FPR-specific peptide. |
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V133096 | Cys-PCM | Cys-PCM is a cardiomyocyte-targeting peptide (PCM) derived from WLSEAGPVVTVRALRGTGSW, with a cysteine residue at its N-terminus, which can be used for coupling. | |
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V75350 | FPR-A14 | 329691-12-5 | FPR-A14 is a potent formyl peptide receptor (FPR) agonist. |
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V78910 | FPR1 antagonist 1 | FPR1 antagonist 1 (compound 24a) is a formyl peptide receptor 1 (FPR1) antagonist (inhibitor) with IC50 of 25 nM. | |
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V78885 | FPR1 antagonist 2 | FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist (inhibitor) with IC50 of 70 nM. | |
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V136339 | FPR1 antagonist 3 | 3058943-53-3 | FPR1 antagonist 3 is a potent and selective FPR1 antagonist. |
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