CRAC Channel

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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CRAC Channel

T cells, mast cells, and various other tissues express the highly Ca2+-selective store-operated Ca2+ channel known as the Ca2+ release-activated Ca2+ (CRAC) channel. Critical cellular functions like gene expression, motility, and the release of inflammatory mediators are regulated by CRAC channels. The discovery of STIM1, the ER Ca2+ sensor, and Orai1, a crucial subunit of the CRAC channel pore, has given scientists the means to shed light on the regulation mechanisms and pore characteristics of CRAC channels.

STIM1 proteins, which can sense luminal Ca 2+ concentration and are capable of spanning the ER membrane, are in charge of transmitting the Ca2+ store-depletion signal to Orai1 proteins, which form pores in the plasma membrane. Ca2+ can enter the cell again thanks to a direct interaction between STIM1 and Orai1. Immune responses and lymphocyte performance depend on CRAC channels. The immunocompromised phenotype shown by humans and mice with null or loss-of-function mutations in STIM1 or Orai1, which suggests that CRAC channel inhibitors could be useful therapeutics for autoimmune or inflammatory conditions, has been a driving force in the search for CRAC channel drugs.

CRAC Channel related products

Cat No.	Product Name	CAS No.	Product Description
V32322	CM-4620	1713240-67-5	CM4620 (CM-4620) is a novel, potent and selective calcium-release activated calcium-channel (CRAC) inhibitor with antiinflammatory effects.
V87144	CRAC channel inhibitor-1	903591-53-7	CRAC channel inhibitor-1 (compound 55) is a calcium ion release channel CRAC channel inhibitor.
V3598	GSK-5498A	1253186-49-0	GSK-5498A is a novel, potent and selective small molecule blocker of Calcium-Release Activated Calcium (CRAC) channel with IC50 of 1 uM; It inhibits mediator release from mast cells, and pro-inflammatory cytokine release from T-cells in a variety of species.
V29155	Synta66	835904-51-3	Synta66 is a novel and potent inhibitor/blocker of Ca2+ entry via store-operated Ca2+ release-activated Ca2+ (CRAC) channels.