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p97

p97

p97, also known as VCP, is an abundant and highly conserved AAA+ (ATPases associated with diverse cellular activities) ATPase that is crucial for maintaining cellular proteostasis. In addition to extracting proteins from membranes or molecular complexes for proteasomal degradation, p97 also plays key roles in lysosomal degradation through autophagy and endolysosomal sorting, membrane fusion, and the regulation of intracellular signaling, cell proliferation, and survival. These various cellular processes are propelled by the chemical energy released during ATP hydrolysis and are coordinated by p97's interactions with up to 40 cofactors, which direct it to specific subcellular sites and substrates for their processing and remodeling.

Numerous neurodegenerative diseases have been linked to p97 mutations, and overexpression of p97 in its wild-type is seen in many cancers. In addition, it has been demonstrated that p97 activity is necessary for the replication of a number of viruses, including influenza, poliovirus, herpes simplex virus, cytomegalovirus, and herpes simplex virus (HSV). These findings point to the possibility of using p97 targeting as a therapeutic strategy for neurodegeneration, cancer, and some infectious diseases.

p97 related products

Structure Cat No. Product Name CAS No. Product Description
3,4-亚甲二氧基-b-硝基苯乙烯 V1320 MNS (NSC 170724, MDBN) 1485-00-3 MNS (NSC170724; NSC-170724; NSC 170724; 5-(2-Nitrovinyl)benzodioxole)) is a novel, potent and selective TKI-tyrosine kinase inhibitor with anti-platelet activity.
CB-5339 V60010 CB-5339 1863952-15-1 CB-5339 is an orally bioactive p97 inhibitor (antagonist) with IC50 <30 nM and may be utilized in leukemia research.
DBeQ (JRF 12) V1319 DBeQ (JRF 12) 177355-84-9 DBeQ (JRF-12; JRF 12; JRF12) is a reversible and ATP-competitive p97 inhibitor with potential antineoplastic activity.
KUS121 V88716 KUS121 1357164-52-3 KUS121 is a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects and attenuates ischemic retinal cell death by inhibiting endoplasmic reticulum stress.
ML240 V4007 ML240 1346527-98-7 ML240 is a novel potent p97 inhibitor which inhibits p97 ATPase with an IC50 value of 100 nM.
ML241 HCl V4006 ML241 HCl 2070015-13-1 ML241 HCl is a novel and potent p97 inhibitor which inhibits p97 ATPase with an IC50 value of 100 nM.
MSC1094308 V31538 MSC1094308 2219320-08-6 MSC1094308 (MSC-1094308) is a novel and potent allosteric inhibitor of the type II AAA ATPase.
NMS-873 V1318 NMS-873 1418013-75-8 NMS-873 (also known as NMS 873, NMS873, p97 inhibitor) is a potent, allosteric and specific p97 inhibitor with potential antitumor activity.
NSC799462 V97470 NSC799462 NSC799462 is a triazole inhibitor of p97 ATPase.
NSC819701 V97464 NSC819701 NSC819701 is a triazole inhibitor of p97 ATPase.
NW 1028 V41084 NW 1028 2749599-78-6 NW 1028 is a potent VCP/p97 inhibitor.
UP12 V104302 UP12 443353-87-5 UP12 enhances ATPase activity and activates valosin-containing protein (VCP) with an EC50 of 2.57 μM.
UP158 V104301 UP158 489402-33-7 UP158 enhances ATPase activity and activates valosin-containing protein (VCP) with an EC50 of 2.57 μM.
UP163 V104300 UP163 591242-60-3 UP163 enhances ATPase activity and activates valine-containing protein (VCP) with an EC50 of 9.0 μM.
UPCDC30766 V54752 UPCDC30766 2152623-68-0 UPCDC30766 is a potent allosteric inhibitor of p97 with IC50 of 12 nM.
VCP Activator 1 V84513 VCP Activator 1
VCP/p97 inhibitor-1 V35144 VCP/p97 inhibitor-1 2630950-38-6 VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also known as Cdc48, CDC-.
亚瑞司他丁I V12068 Eeyarestatin I 412960-54-4 Eeyarestatin I is a novel and potent ERAD (endoplasmic reticulum-associated protein degradation)inhibitor and protein translocation inhibitor with anticancer activity.
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