The liver has a high activity of the serine protease prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain. Prep may be involved in physiological and pathological processes like peptide maturation and degradation, inflammation, oxidative stress, autophagy, cell proliferation, and cancer, according to growing evidence.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V131452 | CGS 24592 | 147923-04-4 | CGS 24592 is an orally effective selective and potent neutral endopeptidase 24.11 (NEP) inhibitor with an IC50 value of 1.6 nmol/L. |
|
V101163 | DOTA.SA.FAPi TFA | DOTA.SA.FAPi TFA is a bifunctional DATA5m and DOTA chelator composed of squaric acid and UAMC1110. | |
|
V135462 | Eurystatin A | 137563-63-4 | Eurystatin A is a prolyl endopeptidase inhibitor. L-leucine and L-ornithine are direct precursors of the L-leucine and L-ornithine moieties of eurystatin A. |
|
V135463 | Eurystatin B | 137563-64-5 | Eurystatin B is a prolyl endopeptidase (PED) inhibitor. |
|
V138546 | Kynapcin-13 | 476337-32-3 | Kynapcin-13 can inhibit the activity of prolyl endopeptidase (PEP) in a non-competitive manner, with an IC50 value of 76.80 μM. |
|
V138547 | Kynapcin-28 | 476337-33-4 | Kynapcin-28 can inhibit the activity of prolyl endopeptidase (PEP) in a non-competitive manner, with an IC50 value of 76.80 μM. |
|
V143010 | Polyozellin | 197703-46-1 | Polyozellin is a prolyl endopeptidase inhibitor. |
|
V143034 | POP-IN-3 | 2554621-98-4 | POP-IN-3 is a potent covalent prolyl oligopeptidase (POP) inhibitor with a Ki value of 0.95 nM. |
|
V73358 | PREP inhibitor-1 | 2760543-16-4 | PREP inhibitor-1 is a potent inhibitor of prolyl oligopeptidase (PREP) (IC50 < 1 nM). |
|
V143137 | PREP-IN-2 | PREP-IN-2 is a selective prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.53 μM. | |
|
V87686 | Prolyl endopeptidase inhibitor 2 | 2362592-81-0 | Prolyl endopeptidase inhibitor 2 (Compound 8) is a proline endopeptidase (PEP) inhibitor with an IC50 value of 31.11 μM. |
|
V4276 | SP-13786 (UAMC1110, FAP-IN-1) | 1448440-52-5 | SP-13786 (UAMC-1110,FAP-IN-1) is a novel, potent andhighlyselective inhibitor of fibroblast activation protein (FAP) withIC50of 3.2 nM; it also inhibits prolyl oligopeptidase (PREP) with anIC50of 1.8 μM. |
|
V115485 | SUAM 1221 | 112603-82-4 | SUAM 1221 is a prolyl endopeptidase inhibitor. |
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V73361 | Suc-Ala-Pro-pNA | 95632-46-5 | Suc-Ala-Pro-pNA is a bioactive peptide that could be utilized as a substrate to detect the activity and stability of prolyl endopeptidase (PEP). |
|
V73356 | Y-29794 oxalate | 146794-84-5 | Y-29794 oxalate is a selective, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) non-peptide prolyl endopeptidase inhibitor. |
|
V73359 | Z-Pro-Pro-aldehyde-dimethyl acetal | 170116-63-9 | Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor (IC50= 12 nM) of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease. |
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V73362 | Z-Pro-Pro-CHO | 108708-25-4 | Z-Pro-Pro-CHO is a prolyl oligopeptidase inhibitor (IC50= 0.16 μM and 0.01 μM for human and Schistosoma mansoni prolyl oligopeptidase, respectively). |
|
V73360 | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) | 88795-32-8 | Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally bioactive prolyl oligopeptidase (PREP) inhibitor (antagonist) with IC50 of 0.4 nM for porcine PREP. |
|
V73357 | Z-Thioprolyl-Thiazolidine | 118059-38-4 | Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor (antagonist) with Ki of 0.36 nM for bovine brain prolyl endopeptidase. |
|
V73363 | Z-Thioprolyl-Thioproline | 118059-40-8 | Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC50=16 µM; Ki=37 µM). |
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