IRAK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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IRAK

Through their function in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways, interleukin-1 receptor-associated kinases (IRAKs), which are serine/threonine kinases, play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers. Two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M, are among the four distinct IRAK-like molecules that have been discovered. Nuclear factor-kappaB (NF-B) and mitogen-activated protein kinase (MAPK) pathways are both activated by all IRAKs.

The adaptor molecule MyD88 and the IRAK-1, 2, M, and 4 members of the IL-1R-associated kinase family are used by toll-like receptors to transmit their signals. The Myddosomes formed by MyD88-IRAK-4, IRAK-1, and IRAK-2 are known to mediate TLR7-induced, TAK1-dependent NF-B activation. It is known that IRAK-M acts as a negative regulator, preventing the dissociation of IRAKs from MyD88 and obstructing subsequent signaling.

IRAK related products

Cat No.	Product Name	CAS No.	Product Description
V22652	IRAK-1/4 Inhibitor	509093-47-4	IRAK-1-4 Inhibitor I is an IRAK1/4 inhibitor (antagonist) with IC50 of 0.2 μM and 0.3 μM respectively.
V86890	BIO-7488	2573211-25-1	BIO-7488 is a potent, selective, orally active and blood-brain barrier permeable IRAK4 inhibitor with IC50 values of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively.
V86889	BIO-8169	2792153-06-9	BIO-8169 is a selective inhibitor of interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 0.23 nM.
V86885	DW18134	2626988-87-0	DW18134 is an inhibitor of interleukin receptor-associated kinase 4 (IRAK 4) with IC50 of 11.2 nM.
V40494	Emavusertib (CA-4948)	1801344-14-8	Emavusertib (CA-4948) is a first-in-class, orally bioactive and highly potent IRAK4/FLT3 inhibtor (IC50 of < 50 nM) with anticancer activity.
V75059	GLPG2534	2095615-97-5	GLPG2534 is an orally bioactive and selective IRAK4 inhibitor (antagonist) with IC50s of 6.4 nM and 3.5 nM for human and mouse IRAK4.
V75066	GNE-2256	2102170-43-2	GNE-2256 (molecule 19) is an orally bioactive IRAK4 (interleukin 1 receptor-associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM).
V75064	HS271	2410393-15-4	HS271 is a potent, orally bioactive, and selective IRAK4 inhibitor (antagonist) with IC50 of 7.2 μM.
V75057	IRAK degrader-1	2655656-99-6	IRAK degrader-1 (example I-3) is a potent IRAK degrader.
V34066	IRAK inhibitor 1	1042224-63-4	IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
V75063	IRAK inhibitor 4 (trans)	2070014-89-8	IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor 4, which is a potent inhibitor of IRAK4.
V6791	IRAK-IN-6	1042672-97-8	IRAK-IN-6, formerly known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.
V75062	IRAK-4 protein kinase inhibitor 2	301675-24-1	IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin 1 (IL-1) receptor-associated kinase 4 (IRAK-4) with IC50 of 4 μM.
V86892	IRAK1-IN-1		IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor.
V86891	IRAK4 modulator-1	1356014-97-5	IRAK4 modulator-1 (example 161) is a regulator of IRAK4 with IC50=4.647 μM.
V32176	IRAK4-IN-1	1820787-94-7	IRAK4-IN-1 is an inhibitor (blocker/antagonist) of interleukin-1 receptor-associated kinase 4 (IRAK4) with IC50 of 7 nM.
V79329	IRAK4-IN-27		IRAK4-IN-27 (Compound 22) is a potent and specific inhibitor of IRAK4 with IC50 of 8.7 nM.
V75054	IRAK4-IN-28	2952532-92-0	IRAK4-IN-28 (compound 42) is an orally bioactive IRAK4 inhibitor (ICIC50=8.9 nM).
V75055	IRAK4-IN-6	2454244-02-9	IRAK4-IN-6 is an oral, potent and specific IRAK inhibitor (antagonist) with IC50 of 4 nM, targeting MyD88 L265P mutant diffuse large B-cell lymphoma.
V3947	IRAK4-IN-7 (CA4948 analog)	1801343-74-7	IRAK4-IN-7 (CA-4948 analog; AU-4948) is a novel, potent, selective, and orally bioactive small molecule inhibitor of IRAK4 (interleukin-1 receptor-associated kinase 4) which has the potential to be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling.