IRAK

IRAK

Through their function in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways, interleukin-1 receptor-associated kinases (IRAKs), which are serine/threonine kinases, play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers. Two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M, are among the four distinct IRAK-like molecules that have been discovered. Nuclear factor-kappaB (NF-B) and mitogen-activated protein kinase (MAPK) pathways are both activated by all IRAKs.

The adaptor molecule MyD88 and the IRAK-1, 2, M, and 4 members of the IL-1R-associated kinase family are used by toll-like receptors to transmit their signals. The Myddosomes formed by MyD88-IRAK-4, IRAK-1, and IRAK-2 are known to mediate TLR7-induced, TAK1-dependent NF-B activation. It is known that IRAK-M acts as a negative regulator, preventing the dissociation of IRAKs from MyD88 and obstructing subsequent signaling.

IRAK related products

Structure Cat No. Product Name CAS No. Product Description
V40494 Emavusertib (CA-4948) 1801344-14-8 Emavusertib (CA-4948) is a first-in-class, orally bioactive and highly potent IRAK4/FLT3 inhibtor (IC50 of < 50 nM) with anticancer activity.
V75059 GLPG2534 2095615-97-5
V75066 GNE-2256 2102170-43-2
V75064 HS271 2410393-15-4
V75057 IRAK degrader-1 2655656-99-6
V34066 IRAK inhibitor 1 1042224-63-4 IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.
V75063 IRAK inhibitor 4 (trans) 2070014-89-8
V22652 IRAK-1/4 Inhibitor 509093-47-4 IRAK-1/4 Inhibitor is a novel inhibitor of interleukin-1 receptor-associated kinase (IRAK)-1/4.
V75062 IRAK-4 protein kinase inhibitor 2 301675-24-1
V6791 IRAK-IN-6 1042672-97-8 IRAK-IN-6, formerly known as IRAK inhibitor 6, is an interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor.
V32176 IRAK4-IN-1 1820787-94-7 IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.
V79329 IRAK4-IN-27
V75054 IRAK4-IN-28 2952532-92-0
V75055 IRAK4-IN-6 2454244-02-9
V3947 IRAK4-IN-7 (CA4948 analog) 1801343-74-7 IRAK4-IN-7 (CA-4948 analog; AU-4948) is a novel, potent, selective, and orally bioactive small molecule inhibitor of IRAK4 (interleukin-1 receptor-associated kinase 4) which has the potential to be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling.
V2464 JH-X-119-01 2227368-54-7 JH-X-119-01 (JH-X119-01) is a novel, potent, selective and covalent inhibitor of IRAK1 (interleukin-1 receptor-associated kinases 1) (IC50 = 9 nM) with anticancer activity.
V75058 JH-X-119-01 hydrochloride 2591344-30-6
V75067 KTX-497 2432993-46-7
V75070 KTX-612 2573298-14-1
V75065 KTX-955 2573302-50-6
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