A family of powerful bioactive lipids known as leukotriene receptors (cys-LTs) act through two structurally distinct G protein-coupled receptors known as the CysLT1 and CysLT2 receptors. Important mediators of human bronchial asthma include the cysteinyl leukotrienes LTC4, LTD4, and LTE4. The second messenger system that the leukotriene receptor uses is phosphatidylinositol-calcium. It belongs to the superfamily of G protein-coupled receptors. When LTD4 activates CysLT1, smooth muscle contracts and grows more, there is oedema, eosinophil migration, and lung mucus layer damage. LTRAs, or leukotriene receptor antagonists, are a class of non-steroidal oral medications. They may also be known as bronchoconstriction preventors with anti-inflammatory properties. LTRAs function by preventing a chemical process that can result in airway inflammation.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V84100 | (5S,6S)-DiHETE | 82948-87-6 | |
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V86652 | 11(Z),14(Z)-Eicosadienoic acid | 5598-38-9 | 11(Z),14(Z)-Eicosadienoic acid is an unsaturated fatty acid that inhibits the binding of [3H]leukotriene B4 (LTB4) to porcine neutrophil membranes with a Ki of 3 μM. |
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V86648 | 12-epi-LTB4 | 83709-73-3 | 12-epi-LTB4 is an agonist of BLT1 and BLT2. |
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V102652 | 14,15-Dehydro Leukotriene B4 | 114616-11-4 | 14,15-Dehydroleukotriene B4 (Compound 4) is a LTB4 receptor antagonist. |
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V86650 | 5-LOX-IN-6 | 1159576-98-3 | 5-LOX-IN-6 (compound 11a) is a direct, reversible inhibitor of 5-lipoxygenase (5-LO). |
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V114585 | Bay-X-7195 | 143538-27-6 | Bay-X-7195 is a CYS leukotriene 1 receptor (CYS LT1) antagonist. |
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V102664 | BayCysLT2 | 712313-33-2 | BayCysLT2, an isophthalic acid derivative, is a selective and potent cysteine leukotriene 2 (CysLT2) receptor antagonist with IC50 of 53 nM. |
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V114287 | Bisisorhapontigenin A | 332381-09-6 | Diisorhamnosin A is a dimer of isorhamnosin. |
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V75433 | BLT2 antagonist-1 | 2069220-61-5 | BLT2 agonist-1 (compound 15b) is a selective BLT2 antagonist that can inhibit the chemotaxis of CHO-BLT2 cells with IC50 of 224 nM. |
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V75431 | BLT2 probe 1 | 2893803-05-7 | BLT2 probe 1 (compound 13) is a fluorescent probe based on the synthetic BLT2 agonist CAY10583. |
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V115766 | BRI-12349 | 920707-33-1 | BRI-12349 (compound 50) is a dual antagonist of CysLT1R and CysLT2R, with Ki values of 1.03 μM and 6.46 μM, respectively. |
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V115796 | CGP 57698 | 168082-74-4 | CGP 57698 is a potent cysteyl leukotriene receptor antagonist (Ki = 5.7 nM). |
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V114668 | CP-288886 | 221332-74-7 | CP-288886 is a cysLT1 receptor antagonist with a Ki value of 0.004 μM. |
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V75438 | CP-96021 hydrochloride | 167011-22-5 | CP-96021 HCl is a balanced, potent orally bioactive leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist (inhibitor) with Kis of 34 nM and 37 nM, respectively. |
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V5319 | CP105696 | 58081-99-3 | CP-105,696 (CP105696; CP-105696) is an orally bioactive, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5.6 nM for binding human neutrophils; IC50 = 9.7 nM & 30.3 nM, respectively using guinea pig spleen or mouse membranes) that targets LTB4R high- and low-affinity binding sites in a LTB4 non-competitive and competitive manner, respectively. |
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V94548 | CysLT1 receptor antagonist-1 | 119515-00-3 | CysLT1 receptor antagonist-1 (Compound 4) is an antagonist of cysteine leukotriene receptor 1 (CysLT1R) with IC50 of 3.9 μM. |
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V115712 | DS 4574 | 118314-35-5 | DS 4574 is an orally effective peptide leukotriene receptor antagonist and mast cell stabilizer. |
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V115499 | FK-664 | 94936-90-0 | FK-664 is a leukotriene inhibitor. |
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V75430 | FPL-55712 free base | 40785-97-5 | FPL-55712 free base is a leukotriene receptor antagonist. |
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V107062 | Halometasone | 50629-82-8 | Halometasone is a steroid compound that decreases serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) expression. |
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