MMP

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.

MMP related products

Cat No.	Product Name	CAS No.	Product Description
V73230	(R)-ND-336	2252493-33-5	(R)-ND-336 is a potent and specific MMP-9 inhibitor (antagonist) with Ki of 19 nM.
V89019	(S,S)-TAPI-0	143457-40-3	(S,S)-TAPI-0 is a matrix metalloproteinase (MMP) inhibitor that inhibits the growth of Chlamydia trachomatis by inhibiting PDF enzyme activity.
V73262	3,3′-Bisdemethylpinoresinol	340167-81-9	3,3′-Bisdemethylpinoresinol, lignin, is a naturally occurring compound with MMP-1 inhibitory activity on UVA-irradiated human dermal fibroblasts.
V105509	3-Aminobenzene-1,2-diol	20734-66-1
V102751	4-Epianhydrochlortetracycline hydrochloride	158018-53-2
V73256	Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	98992-65-5	Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate and may be utilized to detect MMP12 enzyme activity.
V73254	ADAM8-IN-1	2758892-64-5	ADAM8-IN-1 is a potent ADAM8 inhibitor (antagonist) with IC50 of 73 nM.
V73245	Aderamastat (FP-025)	877176-23-3	Aderamastat (FP-025) is an orally bioactive matrix metalloproteinase 12 (MMP-12) inhibitor.
V87609	Anti-Human/Mouse denatured collagen type-I Antibody (XL313)		Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse derived IgG1, κ antibody inhibitor against human or mouse denatured collagen type-I.
V73222	BPHA	193807-60-2	BPHA is a potent orally bioactive inhibitor of MMP-2, MMP-9 and MMP-14 with IC50 of 12 nM, 16 nM and 17 nM respectively.
V89020	CGS 27023A	169799-04-6	CGS 27023A is a non-peptide, orally active MMP inhibitor with Ki values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 and MMP-9, respectively.
V73233	cis-ACCP	777075-44-2	cis-ACCP is an antimetastatic matrix metalloproteinase 2 (MMP-2) selective inhibitor (antagonist) with oral activity.
V85024	CL-82198 hydrochloride	1188890-36-9
V3665	CTS-1027	193022-04-7	CTS-1027 is a novel, potent small molecule inhibitor ofMMPs (matrix metalloproteinase)withIC50s of 0.3 nM, 0.5 nM forMMP2,MMP13, respectively, and has > 1,000 fold selectivity over MMP1.
V77131	CTTHWGFTLC, CYCLIC TFA		CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor of the matrix metalloproteinases MMP-2 and MMP-9.
V73259	cyclo(RLsKDK) (BK-1361)	1975145-82-4	cyclo(RLsKDK) (BK-1361) is a specific metalloproteinase ADAM8 inhibitor (antagonist) with IC50 of 182 nM.
V51482	cyclo(RLsKDK) (TFA) (BK-1361 (TFA))		inhibitor of metalloproteinase ADAM8
V79188	Dnp-PLGLWA-DArg-NH2 TFA		Dnp-PLGLWA-DArg-NH2 TFA is a fluorescent substrate for MMP-1 and MMP-9.
V73258	Dnp-PYAYWMR	135662-06-5	Dnp-PYAYWMR is a bioactive peptide substrate that selectively targets MMP3.
V73237	FFAGLDD	2703745-70-2	FFAGLDD is an MMP9-selective cleavage peptide for cytosolic delivery of doxorubicin (DOX) and achieves temporally and spatially controlled slow drug delivery and release.