MMP

MMP

MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases.The metzincin superfamily of proteases, to which the MMPs belong, is a larger group of enzymes. MMPs can process a variety of bioactive molecules in addition to breaking down various extracellular matrix proteins. They have been linked to the inactivation of chemokines and cytokines as well as the cleavage of cell surface receptors and the release of apoptotic ligands.Additionally, it is believed that MMPs have a significant impact on the proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense of cells. It is believed that MMP-2 and MMP-9 are crucial for metastasis. MMP-1 is regarded as being significant in osteoarthritis and rheumatoid arthritis. Recent research indicates that MMPs are actively involved in the pathogenesis of aortic aneurysms. The structural proteins of the aortic wall are degraded by excess MMPs. Acute and chronic cardiovascular diseases both exhibit dysregulation of the balance between MMPs and TIMPs.

MMP related products

Structure Cat No. Product Name CAS No. Product Description
V73230 (R)-ND-336 2252493-33-5 (R)-ND-336 is a potent and specific MMP-9 inhibitor (antagonist) with Ki of 19 nM.
V33829 20(R)-Ginsenoside Rh2 112246-15-8 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, works as a cellular anti-proliferation agent.
V73262 3,3′-Bisdemethylpinoresinol 340167-81-9 3,3′-Bisdemethylpinoresinol, lignin, is a naturally occurring compound with MMP-1 inhibitory activity on UVA-irradiated human dermal fibroblasts.
V73256 Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt 98992-65-5 Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate and may be utilized to detect MMP12 enzyme activity.
V10270 Actinonin 13434-13-4 Actinonin is anaturally occurring antibacterial agent isolated from Actinomyces with antibiotic and anti-tumor activity.
V73254 ADAM8-IN-1 2758892-64-5 ADAM8-IN-1 is a potent ADAM8 inhibitor (antagonist) with IC50 of 73 nM.
V73245 Aderamastat (FP-025) 877176-23-3 Aderamastat (FP-025) is an orally bioactive matrix metalloproteinase 12 (MMP-12) inhibitor.
V73244 Andecaliximab (Anti-MMP9 Reference Antibody (andecaliximab)) 1518996-49-0 Andecaliximab is a recombinant IgG4 monoclonal antibody (mAb) targeting matrix metalloproteinase 9 (MMP9).
V31029 Apigenin-7-glucuronide 29741-09-1 Apigenin-7-glucuronide is a novel and potent bioactive compound that inhibits Matrix Metalloproteinases (MMP).
V73222 BPHA 193807-60-2 BPHA is a potent orally bioactive inhibitor of MMP-2, MMP-9 and MMP-14 with IC50 of 12 nM, 16 nM and 17 nM respectively.
V73233 cis-ACCP 777075-44-2 cis-ACCP is an antimetastatic matrix metalloproteinase 2 (MMP-2) selective inhibitor (antagonist) with oral activity.
V85024 CL-82198 hydrochloride 1188890-36-9
V18635 Cordycepin 73-03-0 Cordycepin (3'-Deoxyadenosine) is a nucleoside analogue that can inhibit IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASF).
V3665 CTS-1027 193022-04-7 CTS-1027 is a novel, potent small molecule inhibitor ofMMPs (matrix metalloproteinase)withIC50s of 0.3 nM, 0.5 nM forMMP2,MMP13, respectively, and has > 1,000 fold selectivity over MMP1.
V77131 CTTHWGFTLC, CYCLIC TFA CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor of the matrix metalloproteinases MMP-2 and MMP-9.
V73259 cyclo(RLsKDK) (BK-1361) 1975145-82-4 cyclo(RLsKDK) (BK-1361) is a specific metalloproteinase ADAM8 inhibitor (antagonist) with IC50 of 182 nM.
V51482 cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) inhibitor of metalloproteinase ADAM8
V79188 Dnp-PLGLWA-DArg-NH2 TFA Dnp-PLGLWA-DArg-NH2 TFA is a fluorescent substrate for MMP-1 and MMP-9.
V73258 Dnp-PYAYWMR 135662-06-5 Dnp-PYAYWMR is a bioactive peptide substrate that selectively targets MMP3.
V2065 Edaravone (MCI-186) 89-25-8 Edaravone (formerly known asRadicut; MCI-186; NCI-C03952; NSC 12;Norantipyrine; Norphenazone; trade name:Radicava) is a novel and potent free radical scavenger that has been used clinically to reduce the neuronal damage following ischemic stroke.
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