Acyltransferase (AT) catalyzes the transfer of an acyl moiety from acyl-coenzyme A (acyl-CoA) to an acceptor.Acyltransferases have been connected to a number of diseases and are crucial for the maintenance of homeostasis in the human body. The acyl-CoA:cholesterol AT (ACAT), diacylglycerol AT (DGAT), and monoacylglycerol AT (MGAT) are members of the acyltransferase family, which is involved in the metabolism of lipids.
An intracellular enzyme called ACAT (acyl-coenzyme A:cholesterol acyltransferase) catalyzes the creation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. ACAT1 and ACAT2, two isoenzymes that are encoded by separate genes, are found in mammals. In many tissues, ACATs are crucial for maintaining cellular cholesterol homeostasis.
The final step in the synthesis of triacylglycerol from diacylglycerol and acyl-CoA is catalyzed by the integral membrane enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase). Two distinct membrane-bound polypeptides, known as DGAT1 and DGAT2, are where the majority of the DGAT activity is found.
Acyl-CoA:monoacylglycerol acyltransferase, or MGAT, catalyzes the synthesis of diacylglycerol, a precursor to phospholipids and other lipids with significant physiological importance. Because the assembly of the lipoproteins that carry absorbed fat to other tissues depends on the resynthesis of triacylglycerol, MGAT plays a significant role in the absorption of dietary fat in the intestine.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2204 | DGAT1-IN-3 | 939375-07-2 | DGAT1-IN-3, also known as RO-5006036, is a novel,potent, selective and orally bioavailable inhibitor of DGAT-1, with IC50s of 38 nM for human DGAT-1 and 120 nM for rat DGAT-1. |
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