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Bcr-Abl

Bcr-Abl

Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML).A chromosomal abnormality that results in the formation of a so-called Philadelphia chromosome is the root cause of more than 90% of CML cases. This abnormality results from the fusion of the break point cluster (Bcr) gene at chromosome 22 with the Abelson (Abl) tyrosine kinase gene at chromosome 9, creating a chimeric oncogene (Bcr-Abl) and a constitutively active Bcr-Abl tyrosine kinase that has been linked to the pathogenesis of CML. The tyrosine kinase has been selectively inhibited by substances.

Bcr-Abl related products

Structure Cat No. Product Name CAS No. Product Description
Adaphostin V10305 Adaphostin 241127-58-2 Adaphostin(NSC-680410) is the adamantyl ester of AG957, acting as anovel and potent activator of Fas-mediated death pathwayin Bcr/Abl-positive leukaemia.
AK-HW-90 V84226 AK-HW-90
AKE-72 V85947 AKE-72 2566525-18-4
BCR-ABL kinase-IN-3 V85499 BCR-ABL kinase-IN-3 2699634-21-2
BCR-ABL kinase-IN-3 (dihydrocholide) V85510 BCR-ABL kinase-IN-3 (dihydrocholide)
c-ABL-IN-5 V78599 c-ABL-IN-5 c-ABL-IN-5 is a selective c-Abl inhibitor (antagonist) with neuro-protection effects.
c-ABL-IN-6 V84924 c-ABL-IN-6
DA5-HTL V85041 DA5-HTL
GNF-6 V83693 GNF-6 839708-29-1
HG-7-86-01 V85409 HG-7-86-01 1258391-14-8
ML 2-23 V80789 ML 2-23 ML 2-23 is an effective PROTAC BCR-ABL degrader.
PROTAC BCR-ABL Degrader-1 V76601 PROTAC BCR-ABL Degrader-1 PROTAC BCR-ABL Degrader-1 (Compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker.
SIAIS100 V81390 SIAIS100 SIAIS100 is a potent BCR-ABL PROTAC degrader with DC50 of 2.7 nM.
SNIPER(ABL)-013 V81408 SNIPER(ABL)-013 SNIPER(ABL)-013, which is made up of GNF5 (ABL inhibitor) and Bestatin (IAP ligand) through a linker, can effectively degrade BCR-ABL protein with DC50 of 20 μM.
SNIPER(ABL)-015 V81409 SNIPER(ABL)-015 SNIPER(ABL)-015, which is made up of GNF5 (ABL inhibitor) and MV-1 (IAP ligand) through a linker, can effectively degrade BCR-ABL protein with DC50 of 5μM.
SNIPER(ABL)-019 V81410 SNIPER(ABL)-019 SNIPER(ABL)-019, which is made up of Dasatinib (ABL inhibitor) and MV-1 (cIAP1 ligand) through a linker, can effectively degrade BCR-ABL protein with DC50 of 0.3 μM.
SNIPER(ABL)-020 V76499 SNIPER(ABL)-020 SNIPER(ABL)-020, which is composed of Dasatinib (ABL inhibitor) and Bestatin (IAP ligand) through a linker, can effectively degrade BCR-ABL protein.
SNIPER(ABL)-044 V81411 SNIPER(ABL)-044 SNIPER(ABL)-044, which is made up of HG-7-85-01 (ABL inhibitor) and Bestatin (IAP ligand) through a linker, can effectively degrade BCR-ABL protein with DC50 of 10 μM.
SNIPER(ABL)-047 V81412 SNIPER(ABL)-047 SNIPER(ABL)-047, which is made up of HG-7-85-01 (ABL inhibitor) and MV-1 (IAP ligand) through a linker, can effectively degrade BCR-ABL protein with DC50 of 2 μM.
SNIPER(ABL)-049 V81413 SNIPER(ABL)-049 SNIPER(ABL)-049, which is made up of Imatinib (ABL inhibitor) and Bestatin (IAP ligand) through a linker, can effectively degrade BCR-ABL protein, with DC50 of 100 μM.
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