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ACE

ACE

By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys. It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. Angiotensin II production and bradykinin metabolism are both reduced when ACE is inhibited (by ACE inhibitors), which results in a general dilation of the arteries and veins and a reduction in arterial blood pressure.

ACE related products

Structure Cat No. Product Name CAS No. Product Description
(R)-MLN-4760 V72996 (R)-MLN-4760 305335-29-9 (R)-MLN-4760, the less active R-isomer of MLN-4760, is an ACE2 inhibitor (antagonist) with IC50 of 8.4 μM.
[Tyr6]-Angiotensin II V73020 [Tyr6]-Angiotensin II 52634-95-4 [Tyr6]-Angiotensin II is a bioactive peptide fragment that binds to angiotensin converting enzyme 2.
Abz-Ser-Pro-3-nitro-Tyr V73001 Abz-Ser-Pro-3-nitro-Tyr 553644-01-2 Abz-Ser-Pro-3-nitro-Tyr is a substrate of ACE2 (ACE (angiotensin-converting enzyme)-2).
Acetyl tetrapeptide-5 V2463 Acetyl tetrapeptide-5 820959-17-9 Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity.
Bradykinin potentiator B (Bradykinin potentiating peptide B) V72998 Bradykinin potentiator B (Bradykinin potentiating peptide B) 30892-86-5 Bradykinin potentiator B is the venom of Agkistrodon halys blomhoffi.
Camellianin B (Camellia flavonoid glycoside B) V73012 Camellianin B (Camellia flavonoid glycoside B) 109232-76-0 Camellianin B, a flavonoid, is a metabolite of Camellianin A.
Delapril-d3 hydrochloride (delapril hydrochloride d3 (hydrochloride)) V73006 Delapril-d3 hydrochloride (delapril hydrochloride d3 (hydrochloride)) 2714473-25-1 Delapril-d3 ( HCl) is the deuterated form of Delapril HCl.
DX600 V72992 DX600 478188-26-0 DX600 is a selective ACE2-specific inhibitor (KD: 1.3 nM) that does not cross-react with ACE.
Enalaprilat-d5 (Enalaprilat D5; MK-422 d5) V72997 Enalaprilat-d5 (Enalaprilat D5; MK-422 d5) 349554-00-3 Enalaprilat-d5 is the deuterium labelled form of Enalaprilat.
FA-Phe-Phe V73005 FA-Phe-Phe 83661-95-4 FA-Phe-Phe is a furanoyl acryloyl (fa)-amino acid (AA) analogue that targets angiotensin-converting enzyme (ACE).
Ganoderic acid K V73016 Ganoderic acid K 104700-95-0 Ganoderic acid K is a potent ACE (angiotensin-converting enzyme) inhibitor.
H-Ile-Pro-Pro-OH hydrochloride V72993 H-Ile-Pro-Pro-OH hydrochloride 1208862-61-6 H-Ile-Pro-Pro-OH HCl is a milk-derived tripeptide that can inhibit ACE (angiotensin-converting enzyme) with IC50 of 5 μM.
H-Lys-Trp-OH V73011 H-Lys-Trp-OH 50674-18-5 H-Lys-Trp-OH (KW) is an ACE inhibitory peptide with IC50 of 7.8 μM.
H-Pro-Phe-OH V73017 H-Pro-Phe-OH 13589-02-1 H-Pro-Phe-OH is a proline- and phenylalanine-containing dipeptide that serves as a substrate for prolinase.
H-Trp-Phe-OH V73009 H-Trp-Phe-OH 6686-02-8 H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe).
H-Tyr-Lys-OH V73015 H-Tyr-Lys-OH 54925-88-1 H-Tyr-Lys-OH is a dipeptide that could be utilized as a biomarker for AJH-1.
Imidapril-d3 hydrochloride (Imidapril d3 hydrochloride) V73004 Imidapril-d3 hydrochloride (Imidapril d3 hydrochloride) 1356017-30-5 Imidapril-d3 ( HCl) is the deuterium labelled form of Imidapril HCl.
Isocrenatoside V73014 Isocrenatoside 221895-09-6 Isocrenatoside (compound 6) is a cyclic octapeptide and an inhibitor (blocker/antagonist) of angiotensin-converting enzyme (ACE).
Isomartynoside V73013 Isomartynoside 94410-22-7 Isomartynoside is a potent angiotensin-converting enzyme (ACE) inhibitor (antagonist) with IC50 of 505.9 µM.
L-Isoleucyl-L-arginine V72990 L-Isoleucyl-L-arginine 55715-01-0 L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues.
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