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TGF-beta(Smad)

TGF-beta(Smad)

The pleiotropic protein known as transforming growth factor-beta (TGF-) is a member of a superfamily that controls several cellular processes, including growth, development, and differentiation. The Smad proteins, which are the intracellular TGF-beta signaling effectors, are activated by receptors and move into the nucleus where they control transcription. Although this pathway is fundamentally straightforward, cooperation with sequence-specific transcription factors, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and other factors enable significant versatility and diversity of TGF-beta family responses. Smad activation and function are further regulated by other signaling pathways.
Additionally, TGF-beta receptors activate Smad-independent pathways that enable Smad-independent TGF-beta responses in addition to regulating Smad signaling. Abnormal TGF- signaling has been linked to a number of illnesses, including cancer, cardiovascular disease, and fibrosis. Consequently, it is acknowledged that the TGF-signaling pathway is a potential drug target.

TGF-beta(Smad) related products

Structure Cat No. Product Name CAS No. Product Description
3,3-Dimethyl-1-butanol (DMB; Neohexanol) V67548 3,3-Dimethyl-1-butanol (DMB; Neohexanol) 624-95-3 3,3-Dimethyl-1-butanol (DMB) is an orally bioavailable inhibitor of trimethylamine (TMA) and trimethylamine-N-oxide (TMAO).
3,7-DMF V67546 3,7-DMF 20950-52-1 3,7-DMF is an orally bioavailable inhibitor of TGF-β1-induced HSC activation.
Carotuximab (TRC105; DE-122) V67554 Carotuximab (TRC105; DE-122) 1268714-50-6 Carotuximab (TRC105) is an IgG1 monoclonal antibody (mAb) that blocks endoglin (CD105) and its downstream Smad signaling pathway.
Cirevetmab (ZTS-00521426) V67558 Cirevetmab (ZTS-00521426) 2473240-98-9 Cirevetmab (ZTS-00521426) is an immunoglobulin G2-kappa, Canis lupus familiaris TGFB1 canine-derived monoclonal antibody (mAb).
Dalbergioidin V67562 Dalbergioidin 30368-42-4 Dalbergioidin is a well-known anthocyanin that improves doxorubicin-induced renal fibrosis by inhibiting the TGF-β signaling pathway.
DT-6 V67547 DT-6 2414315-95-8 DT-6 is a potent inhibitor of TGF-β1.
Elezanumab (elezanumab; ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)) V67559 Elezanumab (elezanumab; ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)) 1791416-49-3 Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody (mAb) that selectively targets repulsive guide molecule A (RGMa).
Hydrochlorothiazid-d2 (HCTZ-d2) V67561 Hydrochlorothiazid-d2 (HCTZ-d2) 1219798-89-6 Hydrochlorothiazid-d2 is the deuterated form of Hydrochlorothiazide.
Hydrochlorothiazide-13C6 (HCTZ-13C6) V67563 Hydrochlorothiazide-13C6 (HCTZ-13C6) 1261396-79-5 Hydrochlorothiazide-13C6 is 13C (carbon 13) labelled Hydrochlorothiazide.
LDN-193189 2HCl V3250 LDN-193189 2HCl 1435934-00-1 LDN193189 2HCl is the dihydrochloride salt ofLDN193189, which is a highly potent andselective small molecule inhibitor of the BMP (bone morphogenetic protein) signaling pathway.
Lerdelimumab (CAT-152) V67560 Lerdelimumab (CAT-152) 285985-06-0 Lerdelimumab (CAT-152) is a human IgG4 anti-TGF-β2 recombinant monoclonal antibody (mAb).
Livmoniplimab (ABBV-151; ARGX-115) V67552 Livmoniplimab (ABBV-151; ARGX-115) 2412004-88-5 Livmoniplimab (ABBV-151; ARGX-115) is a potent, humanized anti-LRRC32 (GARP)/TGFβ1 monoclonal antibody (mAb).
Luspatercept (ACE-536; luspatercept–aamt) V67553 Luspatercept (ACE-536; luspatercept–aamt) 1373715-00-4 Luspatercept (ACE-536) is a recombinantly modified ActRIIB fusion protein that binds to transforming growth factor beta superfamily ligands.
Myristoyl tetrapeptide-12 V67566 Myristoyl tetrapeptide-12 959610-24-3 Myristoyl tetrapeptide-12 directly activates SMAD2 and induces the association of SMAD3 with DNA.
Nisevokitug (NIS-793) V67565 Nisevokitug (NIS-793) 2649854-92-0 Nisevokitug (NIS-793) is a human IgG2λ antibody targeting TGF-beta (TGFB1/TGFB2).
Oxymatrine (Matrine N-oxide) V2022 Oxymatrine (Matrine N-oxide) 16837-52-8 Oxymatrine (also known as Matrine N-oxide)is a naturally occuring quinolizidine alkaloid isolated from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases such as colpitis, psoriasis and eczema etc.
Ponsegromab (PF 06946860) V67550 Ponsegromab (PF 06946860) 2368950-15-4 Ponsegromab (PF 06946860) is a potent and specific humanized anti-GDF15 antibody inhibitor (antagonist) with anti-cachexia activity.
SIS3 free base V2407 SIS3 free base 1009104-85-1 SIS3 is a potent and selective inhibitor of Smad3 function.
SIS3 free base V67551 SIS3 free base 521985-36-4 SIS3 free base is a potent and specific inhibitor of Smad3 phosphorylation.
SIS3 HCl V2956 SIS3 HCl 521984-48-5 SIS3 HCl is a potent and selective inhibitor of Smad3 which is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix.
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