Antifolate

Antifolate

Antifolates agents work by antagonizing (blocking) the actions of folic acid (vitamin B9).Antifolates have a cytotoxic effect on cells during the S-phase of the cell cycle, acting specifically during DNA and RNA synthesis. Antifolates that target folate metabolism have been crucial in the development of medications for the treatment of inflammatory, microbial, parasitic, and cancerous diseases.

Antifolates prevent cell division, DNA/RNA synthesis and repair, and protein synthesis because folate (folic acid) cofactors are necessary for the synthesis and metabolism of amino acids. Some drugs, including proguanil, pyrimethamine, and trimethoprim, specifically block the effects of folate on bacteria, protozoa, and fungi. Dihydrofolate reductase (DHFR), thymidylate synthase (TS), GARFTase, and AICARFTase are examples of prominent antifolate enzyme targets and the antifolates that specifically target these enzymes.

Antifolate related products

Structure Cat No. Product Name CAS No. Product Description
V50929 Aditoprime (Aditoprim) 56066-63-8 Aditoprime (Aditoprim) is a novel and potent bacterial inhibitor of dihydrofolate reductase (DHFR) that prevents dihydrofolic acid from becoming tetrahydrofolic acid.
V80022 Antitumor agent-99
V2074 Calcium Levofolinate ( Calcium levofolinate; CL307782) 80433-71-2 Calcium Levofolinate (also known as Calcium Folinate; Calcium levofolinate; CL307782), a calcium salt of andthe enantiomerically active form of folinic acid, is widely used asan adjuvantin cancer chemotherapy, e.
V77116 Cycloguanil-d6 (Chlorguanide triazine-d6)
V52100 Fanotaprim (VYR-006) 2120282-75-7
V80562 Levomefolate-13C5 calcium (5-Methyltetrahydrofolic Acid-13C5 (calcium salt))
V56538 Methotrexate metabolite-d3 (DAMPA-d3) 1794780-00-9
V55048 Mirvetuximab (M9346A) 1453084-36-0
V41272 Pemetrexed 137281-23-3 Pemetrexed (LY-231514;LY231514;HSDB7316;HSDB-7316; trade name Alimta), a synthetic pyrimidine-based antifolate, is antimetabolite anticancer drug that inhibits TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
V21971 Pemetrexed disodium heptahydrate 357166-29-1 Pemetrexed disodium heptahydrate (LY231514;HSDB7316; LY-231514;HSDB-7316; Alimta), the heptahydrated disodium salt of Pemetrexed and a pyrimidine-based antifolate, is an antifolate and antimetabolite anticancer medication.
V52603 Proguanil-d4 (proguanil-d4) 1189805-15-9
V56376 Proguanil-d4 hydrochloride 1189671-34-8
V52542 Pyrimethamine-d3 (Pyrimethamine-d3) 1189936-99-9
V35227 Talotrexin (PT523) 113857-87-7
V35207 Tetroxoprim (HE 781) 53808-87-0
V35013 Trimethoprim lactate (Trimethoprim lactate) 23256-42-0
V56323 Trimethoprim-d3 (trimethoprim d3) 1189923-38-3
V52820 Trimethoprim-d9 (Trimethoprim d9) 1189460-62-5
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