The farnesoid X receptor (FXR) is a nuclear receptor superfamily member and ligand-activated transcription factor. By binding to DNA as a monomer or a heterodimer with the common NR partner, retinoid x receptor (RXR), to FXR response elements, FXR controls the expression of numerous genes. Two known FXR genes exist, the FXRα and FXRβ.
FXR is primarily expressed in the liver and small intestine, where it is critical for the metabolism of bile acids, lipids, and glucose. FXR regulates bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, as well as playing a significant role in intestinal bacterial growth and liver regeneration through its specific target genes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V12283 | BAR-502 | 1612191-86-2 | BAR502 is a dual FXR and GPBAR1 agonist. |
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V17434 | Chenodeoxycholic Acid | 474-25-9 | Chenodeoxycholic acid (Anthropodesoxycholic acid; Anthropodeoxycholic acid) is a naturally occurring bile acid (found in the body) acting asan apoptosis inducer via PKC-dependent signalling pathway. |
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V4157 | Fexaramine | 574013-66-4 | Fexaramine is a novel, potent, selectivesmall molecule agonist offarnesoid X receptor (FXR)agonist with an EC50 of 25 nM and with 100-fold increased affinity relative to natural compounds. |
|
V1841 | GW4064 | 278779-30-9 | GW4064 (GW-4064) is a novel, potent and selective agonist of farnesoid X receptor (FXR) (EC50 of 65 nM in CV1 cell line) with potential usefulness in the treatment of cholestatic liver disease. |
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V1843 | Lithocholic acid | 434-13-9 | Lithocholic acid (3α-Hydroxy-5β-cholanic acid), a secondary bile acid formed from chenodeoxycholate by bacterial action, acts as a detergent to solubilize fats for absorption and is itself absorbed. |
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V4869 | LY2562175 | 1103500-20-4 | LY2562175 (LY-2562175) is a novel, potent and selective FXR agonist (EC50 = 193 nM) with lipid modulating activity, e. |
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V26486 | Nidufexor (LMB-763) | 1773489-72-7 | Nidufexor, formerly known as LMB 763, is a novel, potent and orally bioactivefarnesoid X receptor (FXR) agonist. |
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V3701 | Tropifexor | 1383816-29-2 | Tropifexor (also known as LJN452) is a novel, potent and highly potent agonist of FXR (farnesoid X receptor) with an EC50 value of 0.2 nM in HTRF assay. |
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V1842 | Turofexorate Isopropyl (XL335) | 629664-81-9 | Turofexorate Isopropyl (also known as WAY-362450, Fxr 450 and XL335) is a novel, highly potent, selective and orally bioavailable FXR (farnesoid X receptor) agonist with EC50 of 4 nM, it is highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. |
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V27882 | Ursodiol | 128-13-2 | Ursodiol (UDCA; Ursodeoxycholic acid) is a novel and natural bile acidwith significant colon chemopreventive activity. |
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V2180 | Vonafexor | 1192171-69-9 | Vonafexor (EYP001) is an orally bioactive and selective non-steroidal FXR agonist. |
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V10614 | Z/E-Guggulsterone | 95975-55-6 | Guggulsterone is a phytosterol developed from the gum resin of the Commiphora wightii tree. |
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