The common herpesvirus family includes the double-stranded DNA virus known as cytomegalovirus (CMV). Cytomegaloviruses evade immune clearance and endure for the entirety of the infected host's life. However, the balance of this virus-host interaction is unstable and depends on the cellular immune response, which typically necessitates the activity of particular CD8 T lymphocytes.
The herpesvirus family, also known as the herpesviridae or human herpesvirus-5 (HHV-5), includes the human cytomegalovirus. Salivary glands and human cytomegalovirus infections are frequently linked. While CMV infection may not cause any symptoms in healthy individuals, it can be fatal in an immunocompromised patient. Congenital cytomegalovirus infection can be fatal or cause serious illness. CMV frequently remains dormant after infection, but it could reactivate at any time. It eventually results in mucoepidermoid carcinoma and is thought to be the cause of prostate cancer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V35042 | Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) | 207226-35-5 | Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a chelating agent and a useful antidote (eg, acute cadmium poisoning). |
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V52093 | Fiztasovimab (NPC-21; EV2038) | 2467411-25-0 | Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ monoclonal antibody (mAb) with activity against human cytomegalovirus (hCMV). |
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V54158 | Fomivirsen (ISIS-2922 free base) | 144245-52-3 | Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphothio-oligonucleotide. |
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V3910 | LETERMOVIR | 917389-32-3 | Letermovir (formerly MK-8828;MK8828; AIC-246; AIC246;trade name:Prevymis) is a potent anti-cytomegalovirus (CMV) / antiviral drug approved on 11/8/2017 by FDA to prevent infection after bone marrow transplant. |
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V4957 | Maribavir | 176161-24-3 | Maribavir (1263W94;BW-1263W94;GW-1263; SHP-620;GW-257406X; VP-41263; Livtencity),an experimental oral antiviral (anti-CMV) drug candidate, is a novel and potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro with an IC50of 3 nM. |
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V54159 | Regavirumab (MCA C23; TI-23) | 153101-26-9 | Regavirumab (MCA C23) is a human monoclonal antibody (mAb) against cytomegalovirus (CMV), human serum albumin (HSA), and glycine. |
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V54160 | SB-734117 | 607368-97-8 | SB-734117 is an inhibitor (blocker/antagonist) of human cytomegalovirus (HCMV) replication that prevents CREB and histone H3 post-translational modifications. |
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V36809 | Sevirumab (MSL-109) | 138660-96-5 | Sevirumab (MSL-109) is a human anti-cytomegalovirus (CMV) IgG1 neutralizing monoclonal antibody (mAb). |
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V4218 | Tomeglovir | 233254-24-5 | Tomeglovir (also known as BAY-38-4766) is a novel, potent andnon-nucleoside anti-CMV (cytomegalovirus) agent which inhibits processing of viral DNA-concatemers withIC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. |
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V81615 | Tricin-d6 | Tricin-d6 is the deuterated form of Tricin. | |
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V52560 | Valganciclovir-d5 TFA (Valganciclovir-d5) | 1402924-31-5 | Valganciclovir-d5 (TFA) is the deuterated form of Valganciclovir TFA. |
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V52550 | Valganciclovir-d8 hydrochloride (Valganciclovir-d8 hydrochloride) | 1132088-63-1 | Valganciclovir-d8 ( HCl) is the deuterium labelled form of Valganciclovir HCl. |
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