TrxR is a pyridine nucleotide-disulphide oxidoreductase that contains selenium. Mammalian TrxRs come in three different isoforms: TrxR1 (TXRND1), TrxR2 (TXNRD2), and TrxR3 (TGR). Thioredoxin (Trx), a redox protein, is reduced by NADPH in a NADPH-dependent manner thanks to TrxRs. TrxR plays a crucial role in controlling the intracellular redox environment, cell division and growth, and the recycling of ascorbate from its oxidized state. Cancers, metabolic syndrome, insulin resistance, type 2 diabetes, hypertension, and atherosclerosis are all linked to the Trx/TrxR system.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V111245 | As-CA11 | As-CA11 is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 18.7 nM. | |
|
V51568 | CPUL-1 | 2043660-80-4 | CPUL1 is a TrxR dye that shows proliferation inhibition and antimetastatic activity on A549 cells. |
|
V118512 | CS47 | 1372792-51-2 | CS47 is a reversible thioredoxin reductase 1 (TrxR1) inhibitor. |
|
V103668 | DDHF20 | DDHF20 is a bacteriostatic agent against Staphylococcus aureus that inhibits thioredoxin reductase (TrxR) and acts as a competitive inhibitor of the NADPH binding site. | |
|
V72099 | DVD-445 | 2375846-41-4 | DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor (antagonist) with IC50 of 0.60 μM. |
|
V109937 | Thioredoxin Reductase, E. coli | Escherichia coli thioredoxin reductase (EC 1.8.1.9) is a thioredoxin reductase (TrxR) derived from Escherichia coli. | |
|
V72100 | TP-TRFS | 2937819-61-7 | TP-TRFS is the first selective two-photon fluorescent probe for thioredoxin reductase (TrxR). |
|
V72101 | TRFS-green | 1513848-14-0 | TRFS-green is a selective fluorescent probe for imaging the selenoprotein thioredoxin reductase (TrxR) in living cells. |
|
V72102 | TrxR-IN-2 | 2866261-50-7 | TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor and a promising candidate active molecule for studying drug-resistant hepatocellular carcinoma. |
|
V72103 | TrxR-IN-4 | 2414906-32-2 | TrxR-IN-4 (Compound 1b) is a potent TrxR inhibitor. |
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V81629 | TrxR-IN-6 | 3032446-53-7 | TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces the accumulation of reactive oxygen species (ROS) and has anti-neoplastic activity. |
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V81628 | TrxR1-IN-1 | TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC50= 8.8 μM). | |
|
V14821 | Ethaselen | 217798-39-5 | Ethaselen (BBSKE)is a novel, oral and potent organoselenium-based inhibitor of thioredoxin reductase(TrxR)with potential anticancer activity. |
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