Notch signaling functions in a wide range of cell types and at different stages of development and is evolutionarily conserved. Transmembrane ligands on one cell activate transmembrane receptors on a cell that is next to it, which is how notch signaling takes place.
For the majority of eukaryotic organisms to develop and remain healthy, Notch signaling regulation is essential. Direct cell-cell interactions are required to activate the Notch signaling, which is mediated by the Notch receptors (NOTCH1, 2, 3, and 4) and ligands (DLL1, 3, and 4, JAG1 and 2), which are essential membrane proteins. Through an unusual mechanism involving Notch proteolysis to release the intracellular domain from the membrane, ligand-expressing cells activate Notch signaling. This enables the Notch receptor to directly serve as the downstream signal transducer.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V85167 | Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) | ||
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V3478 | BMS-983970 | 1584713-87-0 | BMS-906024 is a novel,oral and potent pan-Notch inhibitor that demonstrated robust anti-tumor activity at tolerated doses in multiple tumor xenograft models. |
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V4902 | Crenigacestat (LY3039478) | 1421438-81-4 | Crenigacestat (formerly also known as LY3039478) is a novel, potent and orally bioavailable small molecule Notch inhibitor with an IC50 of ~1nM in cell based assays. |
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V86000 | DAPM | 208255-51-0 | |
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V79754 | Heparan Sulfate 3-O-Sulfotransferase 4 (EC:2.8.2.23; HS3ST4; 3-OST-4) | Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. | |
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V19757 | IMR-1 | 310456-65-6 | IMR-1 is a Mastermind Recruitment inhibitor. |
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V19758 | IMR-1A | 331862-41-0 | IMR-1A is a metabolite of IMR-1, IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin. |
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V76872 | Jagged-1 (188-204) (TFA) | Jagged-1 (188-204) TFA is a fragment of the JAG-1 protein with Notch agonist activity. | |
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V15026 | JI051 | 2234281-75-3 | JI051 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. |
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V2290 | Limantrafin(CB-103) | 218457-67-1 | CB-103 is a novel and potent γ-secretase inhibitor that is currently being investigated in Phase-1 dose escalation in cancer patients. |
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V98984 | MO-I-1100 | 1585217-40-8 | MO-I-1100 is an inhibitor of ASPH (aspartyl-(asparagine)-β-hydroxylase) enzyme activity. |
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V99727 | NADI-351 | 2503017-11-4 | NADI-351 is an orally available, potent Notch1 inhibitor that selectively disrupts the Notch1 transcription complex and reduces Notch1 recruitment to target genes. |
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V76690 | Notch 1 TFA | Notch 1 TFA (Notch homolog 1, translocation-associated) is a member of the NOTCH family of genetically encoded proteins. | |
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V31315 | NVS-ZP7-4 | 2349367-89-9 | NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. |
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V69866 | Procyanidin B2 3,3'-di-O-gallate | 79907-44-1 | Procyanidin B2, 3,3'-di-O-gallate is the active ingredient. |
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V69868 | RBPJ Inhibitor-1 (RIN1) | 2682114-39-0 | RBPJ Inhibitor-1 (RIN1) is the first RBPJ inhibitor that blocks the interaction between RBPJ and SHARP. |
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V69872 | SAHM1 | 2050906-89-1 | SAHM1 is a bioactive peptide mimetic of a dominant-negative form of MAML that can inhibit the formation of the canonical Notch transcription complex. |
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V81351 | SAHM1 TFA | SAHM1 TFA is a Notch pathway inhibitor. | |
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V85044 | Yhhu-3792 hydrochloride | 2624336-93-0 | |
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V2423 | Tangeretin (Tangeritin; NSC53909) | 481-53-8 | Tangeretin (also called Tangeritin; NSC53909; NSC618905), a naturally occuring flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor. |