Notch signaling functions in a wide range of cell types and at different stages of development and is evolutionarily conserved. Transmembrane ligands on one cell activate transmembrane receptors on a cell that is next to it, which is how notch signaling takes place.
For the majority of eukaryotic organisms to develop and remain healthy, Notch signaling regulation is essential. Direct cell-cell interactions are required to activate the Notch signaling, which is mediated by the Notch receptors (NOTCH1, 2, 3, and 4) and ligands (DLL1, 3, and 4, JAG1 and 2), which are essential membrane proteins. Through an unusual mechanism involving Notch proteolysis to release the intracellular domain from the membrane, ligand-expressing cells activate Notch signaling. This enables the Notch receptor to directly serve as the downstream signal transducer.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V128675 | AMG-119 | AMG-119 is a humanized IgG1 monoclonal antibody that targets delta-like ligand 3 (DLL3). | |
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V85167 | Anti-DLL3 Antibody (anti-DLL3 arm derived from AMG-757) | ||
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V129610 | ATOX1-IN-1 | 956181-19-4 | ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. |
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V116202 | BMS-871 | 1584631-89-9 | BMS-871 is an orally effective pan-Notch inhibitor with IC50 values of 4/1/4/3 nM for Notch1/2/3/4, respectively. |
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V3478 | BMS-983970 | 1584713-87-0 | BMS-906024 is a novel,oral and potent pan-Notch inhibitor that demonstrated robust anti-tumor activity at tolerated doses in multiple tumor xenograft models. |
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V4902 | Crenigacestat (LY3039478) | 1421438-81-4 | Crenigacestat (formerly also known as LY3039478) is a novel, potent and orally bioavailable small molecule Notch inhibitor with an IC50 of ~1nM in cell based assays. |
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V86000 | DAPM | 208255-51-0 | |
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V120383 | ETN029 | 3066864-32-9 | ETN029 is a DLL3 ligand. |
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V79754 | Heparan Sulfate 3-O-Sulfotransferase 4 (EC:2.8.2.23; HS3ST4; 3-OST-4) | Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. | |
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V19757 | IMR-1 | 310456-65-6 | IMR-1 is a Mastermind Recruitment inhibitor. |
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V19758 | IMR-1A | 331862-41-0 | IMR-1A is a metabolite of IMR-1, IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin. |
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V76872 | Jagged-1 (188-204) (TFA) | Jagged-1 (188-204) TFA is a fragment of the JAG-1 protein with Notch agonist activity. | |
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V15026 | JI051 | 2234281-75-3 | JI051 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. |
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V2290 | Limantrafin(CB-103) | 218457-67-1 | CB-103 is a novel and potent γ-secretase inhibitor that is currently being investigated in Phase-1 dose escalation in cancer patients. |
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V138928 | LIV-1205 (CBA-1205) | LIV-1205 (CBA-1205) is a humanized antibody expressed in CHO cells that targets DLK1. | |
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V139261 | MAb604.107 | MAb604.107 is a human monoclonal antibody (mAb) that targets NOTCH1. | |
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V139578 | MEDI0639 | MEDI0639 is a human monoclonal antibody (mAb) that targets DLL4. | |
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V98984 | MO-I-1100 | 1585217-40-8 | MO-I-1100 is an inhibitor of ASPH (aspartyl-(asparagine)-β-hydroxylase) enzyme activity. |
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V99727 | NADI-351 | 2503017-11-4 | NADI-351 is an orally available, potent Notch1 inhibitor that selectively disrupts the Notch1 transcription complex and reduces Notch1 recruitment to target genes. |
|
V141134 | Neburon | 555-37-3 | Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transfer, thereby disrupting algal growth. |
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