FKBP

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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FKBP

FKBPs (FK506-binding proteins) interact with immunosuppressants like FK506 and Rapamycin. They are a special class of immunophilins. During protein folding processes, FKBPs use their peptidyl-prolyl isomerase (PPIase) activity to catalyze the cis-trans conversion of prolyl bonds in proteins. The FKBPs serve as an exceptional group of chaperones. Protein folding, receptor signaling, protein trafficking, and transcription are just a few of the biochemical processes that FKBPs are involved in. When they are complexed with their ligands, proteins from the FKBP family have significant functional roles in the activation of T cells.

Through their interactions with kinases, steroid hormone receptors, and other cellular components, FKBPs contribute significantly to a number of physiological processes and, more intriguingly, to pathological processes in mammals. Four categories—cytoplasmic, TPR domain, endoplasmic reticulum (ER) or secretory pathway, and nuclear—can be used to categorize mammalian FKBPs. One PPIase domain is present in both the nuclear FKBP25 and 133 and the cytoplasmic FKBP12 and 12.6 isoforms. Multiple TPR domains are found in FKBPs 36, 38, 51, and 52. An N-terminal ER signal peptide is present in the ER FKBPs FKBP13, 19, 22, 23, 60, and 65.

FKBP related products

Cat No.	Product Name	CAS No.	Product Description
V123024	10-SLF	2765058-89-5	10-SLF is a PROTAC FKBP12 degrading agent.
V109020	AP1867-3-(aminoethoxy) hydrochloride	2127390-16-1	AP1867-3-(aminoethoxy) hydrochloride is a synthetic FKBP ligand (PROTAC target protein ligand) based on AP1867.
V129211	AP1867-NH-PEG3-acid		AP1867-NH-PEG3-acid is a target protein ligand-linker conjugate containing the FKBP12F36V ligand AP1867 and the PROTAC linker, and can recruit E3 ligases.
V109049	AP21998	292606-90-7	AP21998 is an Fm (mutant FKBP) domain-selective ligand that can bind to a single FKBPv.
V130627	BRD4/FKBP12 degrader-1		BRD4/FKBP12 degrader-1 is a BRD4/FKBP12 degrader (BRD4 ligand, FKBP12 ligand, linker) with anticancer activity.
V130628	BRD4/FKBP12 degrader-2		BRD4/FKBP12 degrader-2 is a BRD4/FKBP12 degrader with anticancer activity (BRD4 ligand, FKBP12 ligand, linker).
V120135	dTAGV-1	2451573-86-5	dTAGV-1 is a highly efficient and selective PROTAC degrader that can degrade the FKBP12F36V tagged protein.
V136062	FKBP12 ligand-2	3036243-81-6	FKBP12 ligand-2 is a high-affinity FKBP12 targeting ligand.
V136063	FKBP12 ligand-3	3036374-26-9	FKBP12 ligand-3 is a high-affinity FKBP12 targeting ligand.
V136064	FKBP12 Ligand-Linker Conjugate 1	2765059-01-4	FKBP12 Ligand-Linker Conjugate 1 is a conjugate composed of FKBP12 target protein ligands and linkers.
V136066	FKBP12 PROTAC FM4	3115268-06-6	FKBP12 PROTAC FM4 is a PROTAC degrader of FKBP12 with a DC50 value of 0.09-0.22 nM.
V88489	FKBP51-Hsp90-IN-1	433313-64-5	FKBP51-Hsp90-IN-1 (Compound D10) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with an IC50 of 0.1 μM for FKBP51.
V88490	FKBP51-Hsp90-IN-2	601511-07-3	FKBP51-Hsp90-IN-2 (Compound E08) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with IC50 values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively.
V139489	MC-25B		MC-25B is a specific FKBP12 PROTAC degrader.
V33117	S107 hydrochloride	1357476-46-0	S107 hydrochloride is a novel, potent and RyR-selective 1,4-benzothiazepine analogue that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
V88492	SP3N		SP3N is a specific degrader of proline isomerase FKBP12, which is converted into a precursor of active aldehydes (SP3CHO) by amine oxidase metabolism.
V145180	SP3N hydrochloride		SP3N hydrochloride is a specific degrader of prolyl isomerase (FKBP12).
V109065	WAY-380153	363160-12-7	WAY-380153 (compound 24) is an FKBP12 inhibitor.
V1936	Ascomycin (FK520)	104987-12-4	Ascomycin (also known as FK520, FR 900520, Immunomycin), a natural product isolated from Streptomyces, is anethyl analog of tacrolimus (FK506) anda neutral macrolide immunosuppressant, which prevents rejection after an organ transplant.