Urotensin receptor (UT) is a G-protein coupled receptor which binds the peptide hormoneurotensin.The Gq/11-protein-coupled urotensin-II (UT) receptor modulates neuromuscular physiology and mediates intricate hemodynamic effects. Although the UT receptor is expressed at lower levels elsewhere (most notably the central nervous system), it is most abundant in the peripheral vasculature, heart, and kidney. The UT receptor has been linked to osmoregulation and exhibits strong but erratic vasoconstrictor effects in certain vascular beds while mediating vasodilation in others.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74526 | [Orn5]-URP | 782485-03-4 | [Orn5]-URP is a specific and pure antagonist of Urotensin-II receptor (UT) with pEC50 of 7.24. |
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V77484 | [Orn5]-URP TFA | [Orn5]-URP TFA is a specific and pure antagonist of Urotensin-II receptor (UT) with pEC50 of 7.24. | |
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V74525 | [Orn8]-Urotensin II (human) | 479065-85-5 | [Orn8]-Urotensin II (human) is a bioactive peptide analog of urotensin II and a UT receptor agonist. |
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V74528 | AC-7954 | 477313-09-0 | AC-7954 is a selective, non-peptide vasopressin receptor agonist (activator) (EC50= 300 nM for human UII receptor). |
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V74523 | GSK 1562590 hydrochloride | 1003878-07-6 | GSK 1562590 HCl is a high-affinity and selective urotensin-II receptor (UT) antagonist (inhibitor) with pKis of 9.14-9.66 for mammalian recombinants (mouse, rat, cat, monkey, human) and native UT . |
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V77890 | hNTS1R agonist-1 | hNTS1R agonist-1 (Compound 10) is a brain barrier-penetrating hNTS1R full agonist (Ki: 6.9 nM). | |
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V76836 | Latozinemab (AL001) | Latozinemab (AL001) is a recombinant humanized anti-Sortilin monoclonal antibody (mAb). | |
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V20688 | Palosuran (ACT058362) | 540769-28-6 | Palosuran (ACT-058362) is a potent, selective and orally bioactive urotensin II receptor blocker (antagonist) with IC50 of 3.6 nM against CHO cell membranes expressing the human recombinant receptor. |
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V74527 | Palosuran hydrochloride (ACT-058362 hydrochloride) | 2469274-58-4 | Palosuran HCl (ACT-058362 HCl) is a specific and orally bioactive urotensin II receptor antagonist (inhibitor) with IC50 of 3.6 nM against CHO cell membranes expressing the human recombinant receptor. |
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V76482 | SR 142948 dihydrochloride | SR 142948 di-HCl is an orally bioactive, selective non-peptide neurotensin receptor (NT) antagonist (inhibitor) with IC50 of 1.19 in h-NTR1-CHO cells, HT-29 cells and adult rat brain, respectively. | |
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V74524 | UFP-803 | 879497-82-2 | UFP-803 is a potent urotensin-II receptor (UT) ligand. |
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V81665 | UFP-803 TFA | UFP-803 TFA is a potent urotensin-II receptor (UT) ligand. | |
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V76384 | Urotensin II (114-124), human TFA | Urotensin II (114-124), human TFA is an 11-amino acid (AA) residue peptide, an orphan receptor GPR14 agonist, and a potent vasoconstrictor. | |
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V81691 | Urotensin II, mouse | Urotensin II, mouse is an endogenous ligand of the orphan G protein-coupled receptor GPR14 or SENR. |
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